{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:11:30Z","timestamp":1782738690721,"version":"3.54.5"},"reference-count":54,"publisher":"American Society of Hematology","issue":"4","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,8,15]]},"abstract":"<jats:p>The development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a multistep process and can be clinico-pathologically divided into Helicobacter pylori-associated gastritis, low-grade tumors, and high-grade tumors. The molecular events underlying this progression are largely unknown. However, identification of the genes involved in MALT lymphoma-specific t(11;18)(q21;q21) and t(1;14)(p22;q32) has provided fresh insights into the pathogenesis of this disease. T(11;18)(q21;q21) results in a chimeric transcript between the API2 and theMALT1 genes, whereas t(1;14) (p22;q32) causes aberrant nuclear BCL10 expression. Significantly, nuclear BCL10 expression also occurs frequently in MALT lymphomas without t(1;14)(p22;q32), suggesting an important role for BCL10 in lymphoma development. Thirty-three cases of H pylori gastritis, 72 MALT lymphomas, and 11 mucosal diffuse large B-cell lymphomas (DLBCL) were screened for t(11;18)(q21;q21) by reverse transcription\u2013polymerase chain reaction followed by sequencing. BCL10 expression in lymphoma cases was examined by immunohistochemistry. The API2\u2013MALT1 fusion transcript was not detected in H pylorigastritis and mucosal DLBCL but was found in 25 of 72 (35%) MALT lymphomas of various sites. Nuclear BCL10 expression was seen in 28 of 53 (53%) of MALT lymphomas. Of the gastric cases, the largest group studied, the frequency of both t(11;18)(q21;q21) and nuclear BCL10 expression was significantly higher in tumors that showed dissemination to local lymph nodes or distal sites (14 of 18\u2009=\u200978% and 14 of 15\u2009=\u200993%, respectively) than those confined to the stomach (3 of 29\u2009=\u200910% and 10 of 26\u2009=\u200938%). Furthermore, t(11;18)(q21;q21) closely correlated with BCL10 nuclear expression. These results indicate that both t(11;18)(q21;q21) and BCL10 nuclear expression are associated with advanced MALT lymphoma and that their oncogenic activities may be related to each other.<\/jats:p>","DOI":"10.1182\/blood.v98.4.1182","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:40Z","timestamp":1027774000000},"page":"1182-1187","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":199,"title":["T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10"],"prefix":"10.1182","volume":"98","author":[{"given":"Hongxiang","family":"Liu","sequence":"first","affiliation":[{"name":"From the Department of Histopathology, Royal Free and University College Medical School, London; the Cancer Gene Cloning Center, Institute of Cancer Research, Sutton, United Kingdom; and the Department of Pathology, Institute of Pathological Anatomy and Histopathology, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Ye","sequence":"additional","affiliation":[{"name":"From the Department of Histopathology, Royal Free and University College Medical School, London; the Cancer Gene Cloning Center, Institute of Cancer Research, Sutton, United Kingdom; and the Department of Pathology, Institute of Pathological Anatomy and Histopathology, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Dogan","sequence":"additional","affiliation":[{"name":"From the Department of Histopathology, Royal Free and University College Medical School, London; the Cancer Gene Cloning Center, Institute of Cancer Research, Sutton, United Kingdom; and the Department of Pathology, Institute of Pathological Anatomy and Histopathology, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Ranaldi","sequence":"additional","affiliation":[{"name":"From the Department of Histopathology, Royal Free and University College Medical School, London; the Cancer Gene Cloning Center, Institute of Cancer Research, Sutton, United Kingdom; and the Department of Pathology, Institute of Pathological Anatomy and Histopathology, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifat A.","family":"Hamoudi","sequence":"additional","affiliation":[{"name":"From the Department of Histopathology, Royal Free and University College Medical School, London; the Cancer Gene Cloning Center, Institute of Cancer Research, Sutton, United Kingdom; and the Department of Pathology, Institute of Pathological Anatomy and Histopathology, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Bearzi","sequence":"additional","affiliation":[{"name":"From the Department of Histopathology, Royal Free and University College Medical School, London; the Cancer Gene Cloning Center, Institute of Cancer Research, Sutton, United Kingdom; and the Department of Pathology, Institute of Pathological Anatomy and Histopathology, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Isaacson","sequence":"additional","affiliation":[{"name":"From the Department of Histopathology, Royal Free and University College Medical School, London; the Cancer Gene Cloning Center, Institute of Cancer Research, Sutton, United Kingdom; and the Department of Pathology, Institute of Pathological Anatomy and Histopathology, Ancona, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Qing","family":"Du","sequence":"additional","affiliation":[{"name":"From the Department of Histopathology, Royal Free and University College Medical School, London; the Cancer Gene Cloning Center, Institute of Cancer 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