{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:42:01Z","timestamp":1791096121161,"version":"4.1.0"},"reference-count":62,"publisher":"American Society of Hematology","issue":"4","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,8,15]]},"abstract":"<jats:p>Human T-cell leukemia virus type I is the etiologic agent of adult T-cell leukemia\/lymphoma. The Tax protein of this virus is thought to contribute to cellular transformation and tumor development. In this report, we have used a Tax transgenic mouse model of tumorigenesis to study the contribution of nuclear factor (NF)-\u03baB activity to spontaneous tumor cell proliferation and resistance to apoptosis. We have demonstrated elevated expression levels of NF-\u03baB\u2013inducible cytokines, including interleukin (IL)-6, IL-10, IL-15, and interferon (IFN)-\u03b3, in freshly isolated primary tumors from Tax transgenic mice. Inhibitors of NF-\u03baB activity, sodium salicylate and cyclopentenone prostaglandins (prostaglandin A1 and 15-deoxy-\u0394(12,14)-prostaglandin J2), blocked spontaneous proliferation of Tax transgenic mouse spleen cells. In addition, Tax-induced tumor cells, which are resistant to irradiation-induced apoptosis, became sensitive to apoptosis in the presence of sodium salicylate and prostaglandins. These results strongly suggest that Tax-mediated induction of NF-\u03baB activity contributes to tumorigenesis in vivo.<\/jats:p>","DOI":"10.1182\/blood.v98.4.1200","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"1200-1208","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":80,"title":["The contribution of NF-\u03baB activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors"],"prefix":"10.1182","volume":"98","author":[{"given":"Toni","family":"Portis","sequence":"first","affiliation":[{"name":"From the Departments of Medicine, Pathology, and Molecular Microbiology, Washington University School of Medicine, St Louis, MO."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Harding","sequence":"additional","affiliation":[{"name":"From the Departments of 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continuum between acute and chronic adult T-cell leukemia-lymphoma.","volume":"83","author":"Ratner","year":"1987","journal-title":"Am J Med."},{"key":"2020021217464604500_B3","doi-asserted-by":"crossref","first-page":"933","DOI":"10.7326\/0003-4819-117-11-933","article-title":"Chronic myelopathy associated with human T-lymphotropic virus type I (HTLV-I).","volume":"117","author":"Gessain","year":"1992","journal-title":"Ann Intern Med."},{"key":"2020021217464604500_B4","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1182\/blood.V86.10.3619.bloodjournal86103619","article-title":"Molecular mechanisms of human T-cell leukemia\/lymphotropic virus type I infection.","volume":"86","author":"Franchini","year":"1995","journal-title":"Blood."},{"key":"2020021217464604500_B5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/318571a0","article-title":"Identification of the gene responsible for human T-cell leukemia virus transcriptional 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Biol."},{"key":"2020021217464604500_B8","doi-asserted-by":"crossref","first-page":"12814","DOI":"10.1074\/jbc.270.21.12814","article-title":"A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.","volume":"270","author":"Brauweiler","year":"1995","journal-title":"J Biol Chem."},{"key":"2020021217464604500_B9","first-page":"1023","article-title":"HTLV-I Tax induces expression of various immediate early serum responsive genes.","volume":"6","author":"Fujii","year":"1991","journal-title":"Oncogene."},{"key":"2020021217464604500_B10","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.1128\/JVI.65.12.6892-6899.1991","article-title":"Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation.","volume":"65","author":"Arima","year":"1991","journal-title":"J Virol."},{"key":"2020021217464604500_B11","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1126\/science.2843985","article-title":"HTLV-I Tax induces cellular proteins that activate the \u03baB element in the IL-2 receptor alpha gene.","volume":"241","author":"Ballard","year":"1988","journal-title":"Science."},{"key":"2020021217464604500_B12","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1073\/pnas.91.9.3584","article-title":"Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor \u03baB and induces nuclear translocation of transcription factor NF-\u03baB proteins for transcriptional activation.","volume":"91","author":"Hirai","year":"1994","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021217464604500_B13","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S1357-2725(97)00088-5","article-title":"Achieving transcriptional specificity with NF-\u03baB.","volume":"29","author":"Perkins","year":"1997","journal-title":"Int J Biochem Cell Biol."},{"key":"2020021217464604500_B14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0171-2985(11)80534-6","article-title":"Multi-step activation of NF-\u03baB\/Rel transcription factors.","volume":"193","author":"Schmitz","year":"1995","journal-title":"Immunobiology."},{"key":"2020021217464604500_B15","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1126\/science.278.5339.860","article-title":"IKK-1 and IKK-2: cytokine-activated I\u03baB kinases essential for NF-\u03baB activation.","volume":"278","author":"Mercurio","year":"1997","journal-title":"Science."},{"key":"2020021217464604500_B16","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1073\/pnas.95.5.2452","article-title":"Human T cell lymphotropic virus type 1 Tax protein trans-activates interleukin 15 gene transcription through an NF-\u03baB 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B lymphocytes.","volume":"96","author":"Lee","year":"1999","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021217464604500_B20","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1073\/pnas.100119497","article-title":"NF-\u03baB inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells.","volume":"97","author":"Cahir-McFarland","year":"2000","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021217464604500_B21","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.1128\/MCB.16.12.7098","article-title":"Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP-1 domain important for B-lymphocyte transformation: role in NF-\u03baB activation.","volume":"16","author":"Devergne","year":"1996","journal-title":"Mol Cell Biol."},{"key":"2020021217464604500_B22","doi-asserted-by":"crossref","first-page":"12592","DOI":"10.1073\/pnas.94.23.12592","article-title":"The Epstein-Barr virus oncogene product latent membrane 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phosphorylation.","volume":"20","author":"Pise-Masison","year":"2000","journal-title":"Mol Cell Biol."},{"key":"2020021217464604500_B34","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/JVI.73.2.1271-1277.1999","article-title":"Human T-cell leukemia virus type I Tax protein abrogates interleukin-2 dependence in a mouse T-cell line.","volume":"73","author":"Iwanaga","year":"1999","journal-title":"J Virol."},{"key":"2020021217464604500_B35","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1128\/JVI.73.10.7981-7987.1999","article-title":"Induction of Bcl-xl expression by human T-cell leukemia virus type I through NF-\u03baB in apoptosis-resistant T-cell transfectants with Tax.","volume":"73","author":"Tsukahara","year":"1999","journal-title":"J Virol."},{"key":"2020021217464604500_B36","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1073\/pnas.92.4.1057","article-title":"Development of leukemia in mice transgenic for the tax gene of human T-cell 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herpesvirus-associated infected primary effusion lymphoma cells.","volume":"94","author":"Jones","year":"1999","journal-title":"Blood."},{"key":"2020021217464604500_B40","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1182\/blood.V85.12.3423.bloodjournal85123423","article-title":"Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma.","volume":"85","author":"Masood","year":"1995","journal-title":"Blood."},{"key":"2020021217464604500_B41","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1128\/JVI.64.6.3033-3041.1990","article-title":"Identification of interleukin-6 as an autocrine growth factor for Epstein-Barr virus-immortalized B cells.","volume":"64","author":"Tosato","year":"1990","journal-title":"J Virol."},{"key":"2020021217464604500_B42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/23948","article-title":"The anti-inflammatory agents aspirin and salicylate inhibit the activity of I\u03baB 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cells.","volume":"92","author":"Bellosillo","year":"1998","journal-title":"Blood."},{"key":"2020021217464604500_B46","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4049\/jimmunol.154.2.718","article-title":"Lymphokine mRNA expression by transplantable murine B lymphocytic malignancies: tumor-derived IL-10 as a possible mechanism for modulating the anti-tumor response.","volume":"154","author":"Bost","year":"1995","journal-title":"J Immunol."},{"key":"2020021217464604500_B47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1172\/JCI115283","article-title":"Impairment of natural killer functions by interleukin-6 increases lymphoblastoid cell tumorigenicity in athymic mice.","volume":"88","author":"Tanner","year":"1991","journal-title":"J Clin Invest."},{"key":"2020021217464604500_B48","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1006\/viro.1999.9846","article-title":"High levels of IL-4 and IL-10 mRNA and low levels of IL-2, IL-9 and IFN-\u03b3 mRNA in MuLV-induced lymphomas.","volume":"261","author":"Beaty","year":"1999","journal-title":"Virology."},{"key":"2020021217464604500_B49","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/eji.1830221127","article-title":"In vivo production of interleukin-10 by malignant cells in AIDS-lymphomas.","volume":"22","author":"Emilie","year":"1992","journal-title":"Eur J Immunol."},{"key":"2020021217464604500_B50","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1128\/JVI.70.8.5706-5710.1996","article-title":"Increased interleukin-10 mRNA expression in tumor-bearing or persistently lymphocytotic animals infected with bovine leukemia virus.","volume":"70","author":"Pyeon","year":"1996","journal-title":"J Virol."},{"key":"2020021217464604500_B51","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s000110050331","article-title":"Interleukin-15 and its role in chronic inflammatory diseases.","volume":"47","author":"Kirman","year":"1998","journal-title":"Inflamm Res."},{"key":"2020021217464604500_B52","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1182\/blood.V93.10.3494.410k14_3494_3504","article-title":"Interferon-\u03b3 prevents apoptosis in Epstein-Barr virus-infected natural killer cell leukemia in an autocrine fashion.","volume":"93","author":"Mizuno","year":"1999","journal-title":"Blood."},{"key":"2020021217464604500_B53","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1046\/j.1471-4159.1999.0731453.x","article-title":"Sodium salicylate and 17\u03b2-estradiol attenuate nuclear transcription factor NF-\u03baB translocation in cultured rat astroglial cultures following exposure to amyloid A\u03b21-40 and lipopolysaccharides.","volume":"73","author":"Dodel","year":"1999","journal-title":"J Neurochem."},{"key":"2020021217464604500_B54","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.8052854","article-title":"Inhibition of NF-\u03baB by sodium salicylate and aspirin.","volume":"265","author":"Kopp","year":"1994","journal-title":"Science."},{"key":"2020021217464604500_B55","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.4049\/jimmunol.165.4.1743","article-title":"The NF-\u03baB cascade is important in Bcl-xl expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes.","volume":"165","author":"Khoshnan","year":"2000","journal-title":"J Immunol."},{"key":"2020021217464604500_B56","doi-asserted-by":"crossref","first-page":"10106","DOI":"10.1073\/pnas.95.17.10106","article-title":"Epstein-Barr virus-transforming protein latent membrane protein 1 activates transcription factor NF-\u03baB through a pathway that includes the NF-\u03baB-inducing kinase and the I\u03baB kinases IKK\u03b1 and IKK\u03b2.","volume":"95","author":"Sylla","year":"1998","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021217464604500_B57","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0092-8674(00)81447-6","article-title":"HTLV-I Tax protein binds to MEKK1 to stimulate I\u03baB kinase activity and NF-\u03baB activation.","volume":"93","author":"Yin","year":"1998","journal-title":"Cell."},{"key":"2020021217464604500_B58","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1128\/MCB.18.9.5157","article-title":"Human T-cell leukemia virus type I Tax induction of NF-\u03baB involves activation of the I\u03baB kinase \u03b1 (IKK\u03b1) and IKK\u03b2 cellular kinases.","volume":"18","author":"Geleziunas","year":"1998","journal-title":"Mol Cell Biol."},{"key":"2020021217464604500_B59","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1126\/science.1299224","article-title":"Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-\u03baB.","volume":"258","author":"Kitajima","year":"1992","journal-title":"Science."},{"key":"2020021217464604500_B60","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1128\/JVI.73.6.4856-4865.1999","article-title":"Immortalization of CD4+ and CD8+ T lymphocytes by human T-cell leukemia virus type I Tax mutants expressed in a functional molecular clone.","volume":"73","author":"Robek","year":"1999","journal-title":"J Virol."},{"key":"2020021217464604500_B61","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1089\/08892220050193092","article-title":"Studies of the immortalizing activity of HTLV type I Tax, using an infectious molecular clone and transgenic mice.","volume":"16","author":"Ratner","year":"2000","journal-title":"AIDS Res Hum Retroviruses."},{"key":"2020021217464604500_B62","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1128\/JVI.75.5.2185-2193.2001","article-title":"Analysis of p53 inactivation in a human T-cell leukemia virus type I Tax 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