{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:27:14Z","timestamp":1791487634345,"version":"4.3.4"},"reference-count":70,"publisher":"American Society of Hematology","issue":"5","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,9,1]]},"abstract":"<jats:p>Stem cell factor (SCF) binds the receptor tyrosine kinase c-Kit and is critical for normal hematopoiesis. Substitution of valine for aspartic acid 816 (D816V) constitutively actives human c-Kit, and this mutation is found in patients with mastocytosis, leukemia, and germ cell tumors. Immortalized murine progenitor cells (MIHCs) transduced with wild-type c-Kit proliferate in response to SCF, whereas cells expressing D816V c-Kit (MIHC-D816V) are factor-independent and tumorigenic. However, the mechanisms mediating transformation by D816V c-Kit are unknown. The objective of this study was to identify signaling components that contribute to D816V c-Kit\u2013mediated transformation. SCF stimulates association of p85PI3K with phosphorylated tyrosine 721 of wild-type c-Kit. Phosphatidylinositol 3 kinase (PI3K) subsequently contributes to the activation of Akt and Jnks. In contrast, these studies demonstrated that the D816V c-Kit mutant was constitutively associated with phosphorylated p85PI3K, and, downstream of PI3K, Jnk 1 and Jnk 2 were activated but Akt was not. Interestingly, Erks 1 and 2 were not constitutively activated by D816V c-Kit. Thus, D816V c-Kit maintains the activity of PI3K but not of all signaling pathways activated by wild-type c-Kit. Further, all pathways downstream of PI3K are not constitutively active in MIHC-D816V cells. Studies with a PI3K inhibitor and D816V\/Y721F c-Kit, a mutant incapable of recruiting PI3K, indicate that constitutive activation of PI3K through direct recruitment by D816V c-Kit plays a role in factor-independent growth of MIHC and is critical for tumorigenicity.<\/jats:p>","DOI":"10.1182\/blood.v98.5.1365","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"1365-1373","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":120,"title":["Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant"],"prefix":"10.1182","volume":"98","author":[{"given":"RuJu","family":"Chian","sequence":"first","affiliation":[{"name":"From the Basic Research Laboratory and the Laboratory of Immunobiology, Division of Basic Sciences, National Cancer Institute-Frederick, MD; the Hanson Center for Cancer Research, Institute of Medical and Veterinary Science and the Department of Medicine, University of Adelaide, Australia; and the Ludwig Institute for Cancer Research, Biomedicum, Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Young","sequence":"additional","affiliation":[{"name":"From the Basic Research Laboratory and the Laboratory of Immunobiology, Division of Basic Sciences, National Cancer Institute-Frederick, MD; the Hanson Center for Cancer Research, Institute of Medical and Veterinary Science and the Department of Medicine, University of Adelaide, Australia; and the Ludwig Institute for Cancer Research, Biomedicum, Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Danilkovitch-Miagkova","sequence":"additional","affiliation":[{"name":"From the Basic Research Laboratory and the Laboratory of Immunobiology, Division of Basic Sciences, National Cancer Institute-Frederick, MD; the Hanson Center for Cancer Research, Institute of Medical and Veterinary Science and the Department of Medicine, University of Adelaide, Australia; and the Ludwig Institute for Cancer Research, Biomedicum, Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Ro\u0308nnstrand","sequence":"additional","affiliation":[{"name":"From the Basic Research Laboratory and the Laboratory of Immunobiology, Division of Basic Sciences, National Cancer Institute-Frederick, MD; the Hanson Center for Cancer Research, Institute of Medical and Veterinary Science and the Department of Medicine, University of Adelaide, Australia; and the Ludwig Institute for Cancer Research, Biomedicum, Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Leonard","sequence":"additional","affiliation":[{"name":"From the Basic Research Laboratory and the Laboratory of Immunobiology, Division of Basic Sciences, National Cancer Institute-Frederick, MD; the Hanson Center for Cancer Research, Institute of Medical and Veterinary Science and the Department of Medicine, University of Adelaide, Australia; and the Ludwig Institute for Cancer Research, Biomedicum, Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petranel","family":"Ferrao","sequence":"additional","affiliation":[{"name":"From the Basic Research Laboratory and the Laboratory of Immunobiology, Division of Basic Sciences, National Cancer Institute-Frederick, MD; the Hanson Center for Cancer Research, Institute of Medical and Veterinary Science and the Department of Medicine, University of Adelaide, Australia; and the Ludwig Institute for Cancer Research, Biomedicum, Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Ashman","sequence":"additional","affiliation":[{"name":"From the Basic Research Laboratory and the Laboratory of Immunobiology, Division of Basic Sciences, National Cancer 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