{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T16:26:27Z","timestamp":1775751987827,"version":"3.50.1"},"reference-count":40,"publisher":"American Society of Hematology","issue":"6","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytokines, such as interleukin-2 (IL-2), activate intracellular signaling pathways via rapid tyrosine phosphorylation of their receptors, resulting in the activation of many genes involved in cell growth and survival. The deubiquitinating enzyme DUB-2 is induced in response to IL-2 but as yet its function has not been determined. The results of this study show that DUB-2 is expressed in human T-cell lymphotropic virus-I(HTLV-1)\u2013transformed T cells that exhibit constitutive activation of the IL-2 JAK\/STAT (signal transducers and activators of transcription) pathway, and when expressed in Ba\/F3 cells DUB-2 markedly prolonged IL-2\u2013induced STAT5 phosphorylation. Although DUB-2 did not enhance IL-2\u2013mediated proliferation, when withdrawn from growth factor, cells expressing DUB-2 had sustained STAT5 phosphorylation and enhanced expression of IL-2\u2013induced genescis and c-myc. Moreover, DUB-2 expression markedly inhibited apoptosis induced by cytokine withdrawal allowing cells to survive. Taken together these data suggest that DUB-2 can enhance signaling through the JAK\/STAT pathway, prolong lymphocyte survival, and, when constitutively expressed, may contribute to the activation of the JAK\/STAT pathway observed in some transformed cells.<\/jats:p>","DOI":"10.1182\/blood.v98.6.1935","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:47Z","timestamp":1027774007000},"page":"1935-1941","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":40,"title":["The deubiquitinating enzyme DUB-2 prolongs cytokine-induced signal transducers and activators of transcription activation and suppresses apoptosis following cytokine withdrawal"],"prefix":"10.1182","volume":"98","author":[{"given":"Thi-Sau","family":"Migone","sequence":"first","affiliation":[{"name":"From the DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA, and the Division of Pediatric Oncology and 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