{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:54:44Z","timestamp":1761893684890},"reference-count":34,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p>A reduced-intensity conditioning regimen was investigated in 45 patients with hematologic malignancies who were considered poor candidates for conventional myeloablative regimens. Median patient age was 49 years. Twenty-six patients previously failed autologous transplantation, and 18 patients had a refractory disease at the time of transplantation. In order to decrease nonrelapse mortality, and enhance the graft-versus-tumor effect, a program was designed in which a reduced conditioning with thiotepa, fludarabine, and cyclophosphamide was associated with programmed reinfusions of donor lymphocytes for patients without graft-versus-host disease (GVHD), not achieving clinical and molecular remission after transplantation. GVHD prophylaxis consisted of cyclosporine A and methotrexate. Seventeen patients received marrow cells and 28 received mobilized hematopoietic cells. All patients engrafted. The probability of grades II-IV and III-IV acute GVHD were 47% and 13%, respectively. The probability of nonrelapse mortality, progression-free survival, and overall survival were 13%, 57%, and 53%, respectively. Thirteen patients in complete remission had a polymerase chain reaction marker for minimal disease monitoring; 10 achieved molecular remission after transplantation. Nine patients received donor lymphocytes: one patient with mantle cell lymphoma had a minimal response, one patient with refractory anemia with excess of blasts in transformation achieved complete remission, and 7 patients did not respond. At a median follow-up of 385 days (range, 24 to 820 days), 25 patients (55%) were alive in complete remission. Although longer follow-up is needed to evaluate the long-term outcome, the study shows that this regimen is associated with a durable engraftment, has a low nonrelapse mortality rate, and can induce clinical and molecular remissions.<\/jats:p>","DOI":"10.1182\/blood.v99.1.75","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:40Z","timestamp":1027774000000},"page":"75-82","update-policy":"http:\/\/dx.doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":129,"title":["Reduced-intensity conditioning followed by allografting of hematopoietic cells can produce clinical and molecular remissions in patients with poor-risk hematologic malignancies"],"prefix":"10.1182","volume":"99","author":[{"given":"Paolo","family":"Corradini","sequence":"first","affiliation":[{"name":"From the Department of Hematology, Istituto Scientifico HS Raffaele, Milano; Department of Hematology, University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, Istituto Nazionale Tumori, University of Milano; Department of Hematology, University of Verona; Department of Hematology, Ospedali Riuniti, Bergamo; Department of Hematology, S Camillo Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Tarella","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Istituto Scientifico HS Raffaele, Milano; Department of Hematology, University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, Istituto Nazionale Tumori, University of Milano; Department of Hematology, University of Verona; Department of Hematology, Ospedali Riuniti, Bergamo; Department of Hematology, S Camillo Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attilio","family":"Olivieri","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Istituto Scientifico HS Raffaele, Milano; Department of Hematology, University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, Istituto Nazionale Tumori, University of Milano; Department of Hematology, University of Verona; Department of Hematology, Ospedali Riuniti, Bergamo; Department of Hematology, S Camillo Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro M.","family":"Gianni","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Istituto Scientifico HS Raffaele, Milano; Department of Hematology, University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, Istituto Nazionale Tumori, University of Milano; Department of Hematology, University of Verona; Department of Hematology, Ospedali Riuniti, Bergamo; Department of Hematology, S Camillo Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Voena","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Istituto Scientifico HS Raffaele, Milano; Department of Hematology, University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, Istituto Nazionale Tumori, University of Milano; Department of Hematology, University of Verona; Department of Hematology, Ospedali Riuniti, Bergamo; Department of Hematology, S Camillo Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Zallio","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Istituto Scientifico HS Raffaele, Milano; Department of Hematology, University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, Istituto Nazionale Tumori, University of Milano; Department of Hematology, University of Verona; Department of Hematology, Ospedali Riuniti, Bergamo; Department of Hematology, S Camillo Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ladetto","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Istituto Scientifico HS Raffaele, Milano; Department of Hematology, University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, Istituto Nazionale Tumori, University of Milano; Department of Hematology, University of Verona; Department of Hematology, Ospedali Riuniti, Bergamo; Department of Hematology, S Camillo Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Falda","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Istituto Scientifico HS Raffaele, Milano; Department of Hematology, University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, 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University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, Istituto Nazionale Tumori, University of Milano; Department of Hematology, University of Verona; Department of Hematology, Ospedali Riuniti, Bergamo; Department of Hematology, S Camillo Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, Istituto Scientifico HS Raffaele, Milano; Department of Hematology, University of Torino; Division of Hematology, University of Ancona; Medical Oncology\/BMT Unit, Istituto Nazionale Tumori, University of Milano; Department of Hematology, University of Verona; Department of Hematology, Ospedali Riuniti, Bergamo; Department of Hematology, S Camillo Hospital, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Benedetti","sequence":"additional","affiliation":[{"name":"From the 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