{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:56:02Z","timestamp":1790913362068,"version":"4.1.0"},"reference-count":51,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p>To investigate the role of viral expression in individuals infected with human T-cell lymphotropic virus type 1 (HTLV-1), a real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) of HTLV-1 tax messenger RNA (mRNA) using ABI Prism 7700 Sequence Detection System was developed. Using this system, the HTLV-1tax mRNA load was compared with HTLV-1 proviral DNA load, HTLV-1 Tax protein expression, HTLV-1 Tax-specific CD8+T-cell frequency, and disease severity of HTLV-1\u2013associated myelopathy\/tropical spastic paraparesis (HAM\/TSP). This approach was a sensitive and specific technique for the precise quantification of HTLV-1 tax mRNA. The total amount of HTLV-1 taxmRNA and mRNA expression level in HTLV-1\u2013infected cells (mRNA\/DNA ratio) were higher in HAM\/TSP patients than in asymptomatic HTLV-1 carriers. The HTLV-1 tax mRNA load correlated with the HTLV-1 proviral DNA load ex vivo, the Tax protein expression in vitro, and the Tax-specific CD8+ T-cell frequency ex vivo. The HTLV-1 tax mRNA load also correlated with disease severity in HAM\/TSP patients. These data suggest that increased HTLV-1 expression plays an important role in the pathogenesis of HAM\/TSP, and the HTLV-1 tax mRNA level could be a useful predictor of disease progression in patients with HAM\/TSP.<\/jats:p>","DOI":"10.1182\/blood.v99.1.88","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:40Z","timestamp":1027774000000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":234,"title":["Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8+ T cells, and disease severity in HTLV-1\u2013associated myelopathy (HAM\/TSP)"],"prefix":"10.1182","volume":"99","author":[{"given":"Yoshihisa","family":"Yamano","sequence":"first","affiliation":[{"name":"From the Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan; and Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nagai","sequence":"additional","affiliation":[{"name":"From the Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan; and Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Brennan","sequence":"additional","affiliation":[{"name":"From the Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan; and Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Mora","sequence":"additional","affiliation":[{"name":"From the Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan; and Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha S","family":"Soldan","sequence":"additional","affiliation":[{"name":"From the Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan; and Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utano","family":"Tomaru","sequence":"additional","affiliation":[{"name":"From the Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan; and Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Takenouchi","sequence":"additional","affiliation":[{"name":"From the Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan; and Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Izumo","sequence":"additional","affiliation":[{"name":"From the Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan; and Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Osame","sequence":"additional","affiliation":[{"name":"From the Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Japan; and Third Department of Internal Medicine, Faculty of Medicine, Kagoshima 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