{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:19:35Z","timestamp":1793578775297,"version":"4.5.0"},"reference-count":34,"publisher":"American Society of Hematology","issue":"10","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,5,15]]},"abstract":"<jats:p>Life-threatening complications such as graft versus host disease and infection remain major barriers to the success of allogeneic hemopoietic stem cell transplantation (SCT). While pretransplantation conditioning and posttransplantation immunosuppression are important risk factors for infection, the reasons that similarly immunosuppressed transplant recipients show marked variation in frequency of infection after allogeneic SCT are unclear. Mannose-binding lectin (MBL) deficiency is a risk factor for infection in other situations where immunity is compromised. We investigated associations betweenMBL2 gene polymorphisms and risk of major infection following allogeneic SCT. Ninety-seven related allogeneic donor-recipient pairs were studied. Clinical data including survival, days of fever, graft versus host disease incidence and severity, and infection were collected by case note review. Five single-nucleotide polymorphisms in the MBL2 gene were genotyped using the polymerase chain reaction and sequence-specific primers.MBL2 coding mutations were associated with an increased risk of major infection following transplantation. This association was seen for donor (P\u2009=\u2009.002, odds ratio [OR] 4.1) and recipient (P\u2009=\u2009.04, OR 2.6) MBL2 genotype.MBL2 promoter variants were also associated with major infection. The high-producing haplotype HYA was associated with a markedly reduced risk of infection (recipient HYA P\u2009=\u2009.0001, OR 0.16; donor HYA P\u2009=\u2009.001, OR 0.23). Donor MBL2 coding mutations and recipientHYA haplotype were independently associated with infection in multivariate analysis. These results suggest that MBL2genotype influences the risk of infection following allogeneic SCT and that both donor and recipient MBL2 genotype are important. These findings raise the possibility that MBL replacement therapy may be useful following transplantation.<\/jats:p>","DOI":"10.1182\/blood.v99.10.3524","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T21:48:18Z","timestamp":1033508898000},"page":"3524-3529","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":156,"title":["Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation"],"prefix":"10.1182","volume":"99","author":[{"given":"Charles G.","family":"Mullighan","sequence":"first","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Heatley","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Doherty","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Szabo","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Grigg","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Hughes","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Schwarer","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Szer","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Tait","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bik To","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Bardy","sequence":"additional","affiliation":[{"name":"From Research and Development, Australian Red Cross Blood Service, South Australia; and Haematology, Institute of Medical and Veterinary Science; both of Adelaide, Australia; Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia; Bone Marrow Transplant Service, Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital; and Victorian Transplantation and Immunogenetic Service, Australian Red Cross Blood Service Victoria; both of Parkville, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021216021933100_B1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1056\/NEJM200101183440303","article-title":"Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers.","volume":"344","author":"Bensinger","year":"2001","journal-title":"N Engl J Med."},{"key":"2020021216021933100_B2","first-page":"537","article-title":"Bacterial infections.","volume-title":"Hematopoietic cell transplantation.","author":"Wingard","year":"1999","edition":"2nd ed."},{"key":"2020021216021933100_B3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/IAI.68.2.688-693.2000","article-title":"Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition.","volume":"68","author":"Neth","year":"2000","journal-title":"Infect Immun."},{"key":"2020021216021933100_B4","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0167-5699(96)80908-X","article-title":"Mannose-binding lectin: the pluripotent molecule of the innate immune system.","volume":"17","author":"Turner","year":"1996","journal-title":"Immunol Today."},{"key":"2020021216021933100_B5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1084\/jem.170.4.1175","article-title":"The human mannose-binding protein gene. 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liver.","volume":"210","author":"Wild","year":"1983","journal-title":"Biochem J."},{"key":"2020021216021933100_B25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0304-4165(86)90309-0","article-title":"Mannose-binding proteins in human serum: identification of mannose-specific immunoglobulins and a calcium-dependent lectin, of broader carbohydrate specificity, secreted by hepatocytes.","volume":"883","author":"Summerfield","year":"1986","journal-title":"Biochim Biophys Acta."},{"key":"2020021216021933100_B26","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1084\/jem.167.3.1034","article-title":"A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins.","volume":"167","author":"Ezekowitz","year":"1988","journal-title":"J Exp Med."},{"key":"2020021216021933100_B27","first-page":"575","article-title":"Human mannose-binding protein gene is regulated by interleukins, dexamethasone, and heat 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transplantation.","volume":"107","author":"Cooke","year":"2001","journal-title":"J Clin Invest."},{"key":"2020021216021933100_B31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1046\/j.1365-3083.1998.00396.x","article-title":"Reconstitution of opsonizing activity by infusion of mannan-binding lectin (MBL) to MBL-deficient humans.","volume":"48","author":"Valdimarsson","year":"1998","journal-title":"Scand J Immunol."},{"key":"2020021216021933100_B32","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0022-1759(98)00190-2","article-title":"High-level and effective production of human mannan-binding lectin (MBL) in Chinese hamster ovary (CHO) cells.","volume":"222","author":"Ohtani","year":"1999","journal-title":"J Immunol Methods."},{"key":"2020021216021933100_B33","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1567-5769(00)00052-7","article-title":"Recombinant expression of human mannan-binding 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