{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:46:59Z","timestamp":1791920819232,"version":"4.3.4"},"reference-count":21,"publisher":"American Society of Hematology","issue":"10","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,5,15]]},"abstract":"<jats:p>The origin of T cells after highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus 1 (HIV-1) is now under discussion. The possibility of renewed lymphopoiesis in aged thymuses is still controversial. In this work we combine the analysis of na\u0131\u0308ve T cells, T-cell receptor excision circles (TRECs), and computed tomography scanning of thymic tissue to further assess whether the thymus is involved in immune reconstitution. Fifteen antiretroviral-na\u0131\u0308ve HIV-1\u2013infected patients were evaluated during 48 weeks of HAART. At baseline, significant correlation was present among age and both thymic volume and TRECs, and between na\u0131\u0308ve T cells and TRECs. After starting HAART, there was a significant increase at week 12 in na\u0131\u0308ve CD4+and CD8+ T cells, TRECs, and thymic volume. The initial net increases in na\u0131\u0308ve T cells and TREC counts were significantly correlated. Changes in thymic volume and TRECs were also indirectly related; splitting the population into 2 groups of high and low baseline TREC levels, only the group with low TREC levels had significant increases in both TRECs and thymic volume. Thus, the increase in thymic volume might be functional, in response to depleted TREC levels. Taken together, our data strongly suggest a thymic role in immune reconstitution, at least in patients with depleted baseline TREC levels.<\/jats:p>","DOI":"10.1182\/blood.v99.10.3702","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T21:48:18Z","timestamp":1033508898000},"page":"3702-3706","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":113,"title":["T-cell repopulation and thymic volume in HIV-1\u2013infected adult patients after highly active antiretroviral therapy"],"prefix":"10.1182","volume":"99","author":[{"given":"Jaime M.","family":"Franco","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine (the Viral Hepatitis and AIDS Study Group) and Department of Radiology, Hospital Universitario Virgen del Roc\u0131\u0301o, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Rubio","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (the Viral Hepatitis and AIDS Study Group) and Department of Radiology, Hospital Universitario Virgen del Roc\u0131\u0301o, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mart\u0131\u0301nez-Moya","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (the Viral Hepatitis and AIDS Study Group) and Department of Radiology, Hospital Universitario Virgen del Roc\u0131\u0301o, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Leal","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (the Viral Hepatitis and AIDS Study Group) and Department of Radiology, Hospital Universitario Virgen del Roc\u0131\u0301o, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Merchante","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (the Viral Hepatitis and AIDS Study Group) and Department of Radiology, Hospital Universitario Virgen del Roc\u0131\u0301o, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Sa\u0301nchez-Quijano","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (the Viral Hepatitis and AIDS Study Group) and Department of Radiology, Hospital Universitario Virgen del Roc\u0131\u0301o, Seville, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Lissen","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (the Viral Hepatitis and AIDS Study Group) and Department of Radiology, Hospital Universitario Virgen del Roc\u0131\u0301o, Seville, 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