{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:07:58Z","timestamp":1786964878106,"version":"build-2736575974"},"reference-count":15,"publisher":"American Society of Hematology","issue":"11","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:p>Spleen size was assessed in 73 patients with thrombocytosis and in 15 healthy subjects, comparing palpation with ultrasonography (US) measurement of longitudinal diameter and volume. Intraobserver and interobserver variability for volume on US, checked in 12 patients, was very low. Correlation between spleen volume measured by US and that measured by computed tomography was excellent. Splenomegaly was detected by palpation in 25% of patients, by US assessment of longitudinal diameter in 33%, and by US assessment of volume in 52%. After diagnostic work-up, 54 patients had a diagnosis of essential thrombocythemia (ET), 4 of idiopathic myelofibrosis (IMF), and 15 of secondary thrombocytosis (ST). Spleen volume in patients with ST was in the normal range (138\u2009\u00b1\u200947 mL) and was significantly lower than that in patients with ET or IMF (370\u2009\u00b1\u2009210 mL;P\u2009&amp;lt;\u2009.001). Thus, US-measured volume was the most sensitive method for identifying nonpalpable splenomegaly in patients with primary myeloproliferative diseases, and it may help in distinguishing these diseases from reactive disorders.<\/jats:p>","DOI":"10.1182\/blood.v99.11.4228","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T21:48:18Z","timestamp":1033508898000},"page":"4228-4230","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":37,"title":["Measurement of spleen volume by ultrasound scanning in patients with thrombocytosis: a prospective study"],"prefix":"10.1182","volume":"99","author":[{"given":"Marco","family":"Picardi","sequence":"first","affiliation":[{"name":"From the Division of Hematology and Departments of Infectious Diseases, Radiology and Laboratory Medicine, Federico II University Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Martinelli","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Departments of Infectious Diseases, Radiology and Laboratory Medicine, Federico II University Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Ciancia","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Departments of Infectious Diseases, Radiology and Laboratory Medicine, Federico II University Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Soscia","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Departments of Infectious Diseases, Radiology and Laboratory Medicine, Federico II University Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Morante","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Departments of Infectious Diseases, Radiology and Laboratory Medicine, Federico II University Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sodano","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Departments of Infectious Diseases, Radiology and Laboratory Medicine, Federico II University Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Fortunato","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Departments of Infectious Diseases, Radiology and Laboratory Medicine, Federico II University Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Rotoli","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Departments of Infectious Diseases, Radiology and Laboratory Medicine, Federico II University Medical School, Naples, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021220504602500_B1","first-page":"29","article-title":"Experience of the Polycythemia Vera Study Group with essential thrombocythemia: a final report on diagnostic criteria, survival and leukemic transition by treatment.","volume":"34","author":"Murphy","year":"1997","journal-title":"Semin Hematol."},{"key":"2020021220504602500_B2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0037-1963(01)90136-2","article-title":"Evaluation of diagnostic criteria in polycythemia vera.","volume":"38(suppl 2)","author":"Pearson","year":"2001","journal-title":"Semin Hematol."},{"key":"2020021220504602500_B3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/10428199909058421","article-title":"Clinicopathological diagnosis and differential criteria of thrombocythemias in various myeloproliferative disorders by histopathology, histochemistry and immunostaining from bone marrow biopsies.","volume":"33","author":"Thiele","year":"1999","journal-title":"Leuk Lymphoma."},{"key":"2020021220504602500_B4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1600-0609.1988.tb00188.x","article-title":"Use of splenic volume estimation to distinguish primary thrombocythaemia from reactive thrombocytosis.","volume":"40","author":"Messinezy","year":"1988","journal-title":"Eur J Haematol."},{"key":"2020021220504602500_B5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-0609.1993.tb00614.x","article-title":"Measurement of spleen size using gamma camera scintigraphy in essential thrombocythaemia.","volume":"51","author":"Revesz","year":"1993","journal-title":"Eur J Haematol."},{"key":"2020021220504602500_B6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-0609.1996.tb01335.x","article-title":"Assessment of spleen size using gamma camera scintigraphy in newly diagnosed patients with essential thrombocythaemia and polycythaemia vera.","volume":"56","author":"Carneskog","year":"1996","journal-title":"Eur J Haematol."},{"key":"2020021220504602500_B7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2141.1997.1552969.x","article-title":"Spleen sizing by ultrasound in polycythaemia and thrombocythaemia: comparison with SPECT.","volume":"98","author":"Messinezy","year":"1997","journal-title":"Br J Haematol."},{"key":"2020021220504602500_B8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1148\/radiology.149.2.6622701","article-title":"Sonographic measurements of the normal liver, spleen, pancreas and portal vein.","volume":"149","author":"Niederau","year":"1983","journal-title":"Radiology."},{"key":"2020021220504602500_B9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7863\/jum.1984.3.1.19","article-title":"Determination of a splenic volumetric index by ultrasonic scanning.","volume":"3","author":"Pietri","year":"1984","journal-title":"J Ultrasound Med."},{"key":"2020021220504602500_B10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jcu.1870190106","article-title":"Sonographic assessment and grading of spleen size.","volume":"19","author":"Ishibashi","year":"1991","journal-title":"J Clin Ultrasound."},{"key":"2020021220504602500_B11","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/thx.46.6.454","article-title":"Repeatability and method comparison.","volume":"46","author":"Chinn","year":"1991","journal-title":"Thorax."},{"key":"2020021220504602500_B12","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0168-8278(97)80141-9","article-title":"Interobserver and interequipment variability of hepatic, splenic and renal arterial Doppler resistance indices in normal subjects and patients with cirrhosis.","volume":"27","author":"Sacerdoti","year":"1997","journal-title":"J Hepatol."},{"key":"2020021220504602500_B13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/028418519403500210","article-title":"CT assessment of normal splenic size in children.","volume":"35","author":"Prassopoulos","year":"1994","journal-title":"Acta Radiol."},{"key":"2020021220504602500_B14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1054\/blre.2001.0158","article-title":"Current opinion in essential thrombocythemia: pathogenesis, diagnosis, and management.","volume":"15","author":"Tefferi","year":"2001","journal-title":"Blood Rev."},{"key":"2020021220504602500_B15","first-page":"1126","article-title":"Relevance of bone marrow features in the differential diagnosis between essential thrombocythemia and early stage idiopathic myelofibrosis.","volume":"85","author":"Thiele","year":"2000","journal-title":"Haematologica."}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/99\/11\/4228\/1685161\/h81102004228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/99\/11\/4228\/1685161\/h81102004228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T01:59:01Z","timestamp":1581559141000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/99\/11\/4228\/106813\/Measurement-of-spleen-volume-by-ultrasound"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,1]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,6,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.v99.11.4228","relation":{},"ISSN":["1528-0020","0006-4971"],"issn-type":[{"value":"1528-0020","type":"electronic"},{"value":"0006-4971","type":"print"}],"subject":[],"published":{"date-parts":[[2002,6,1]]}}}