{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:01:27Z","timestamp":1791234087976,"version":"4.1.0"},"reference-count":299,"publisher":"American Society of Hematology","issue":"2","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acquired chromosomal anomalies (most commonly translocations) in lymphoma and leukemia usually result in either activation of a quiescent gene (by means of immunoglobulin or T-cell\u2013receptor promotors) and expression of an intact protein product, or creation of a fusion gene encoding a chimeric protein. This review summarizes current immunocytochemical studies of these 2 categories of oncogenic protein, with emphasis on the clinical relevance of their detection in diagnostic samples. Among the quiescent genes activated by rearrangement, expression of cyclin D1 (due to rearrangement of theCCND1 [BCL-1] gene) is a near-specific marker of t(11;14) in mantle cell lymphoma; BCL-2 expression distinguishes follicular lymphoma cells from their nonneoplastic counterparts in reactive germinal centers and appears to be an independent prognostic marker in diffuse large cell lymphoma; andTAL-1 (SCL) expression identifies T-cell acute lymphoblastic neoplasms in which this gene is activated. The protein products of other genes activated by chromosomal rearrangement have a role as markers of either lineage (eg, PAX-5 [B-cell\u2013specific activator protein] for B cells, including B-lymphoblastic neoplasms), or maturation stage (eg, BCL-6 for germinal-center and activated B cells and MUM-1\/IRF4 for plasma cells). Currently, no hybrid protein encoded by fusion genes is reliably detectable by antibodies recognizing unique junctional epitopes (ie, epitopes absent from the wild-type constituent proteins). Nevertheless, staining for promyelocytic leukemia (PML) protein will detect acute PML with t(15;17) because the microspeckled nuclear labeling pattern for PML-RAR\u03b1 is highly distinctive. Similarly, antibodies to the anaplastic lymphoma kinase (ALK) tyrosine kinase are valuable (because wild-type ALK is not found in normal lymphoid tissue) in detecting neoplasms (CD30-positive large T-cell lymphomas) with t(2;5) or its variants. Thus, immunocytochemical detection of the products of many rearranged genes in lymphoma and leukemia can be clinically informative and provide information on cellular and subcellular protein expression that cannot be inferred from studies based on messenger RNA.<\/jats:p>","DOI":"10.1182\/blood.v99.2.409","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:40Z","timestamp":1027774000000},"page":"409-426","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":152,"title":["Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry"],"prefix":"10.1182","volume":"99","author":[{"given":"Brunangelo","family":"Falini","sequence":"first","affiliation":[{"name":"From the Institute of Hematology, University of Perugia, Italy; and the LRF Immunodiagnostics Unit, John Radcliffe Hospital, Oxford, England."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Y.","family":"Mason","sequence":"additional","affiliation":[{"name":"From the Institute of Hematology, University of Perugia, Italy; and the LRF Immunodiagnostics Unit, John Radcliffe Hospital, Oxford, England."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021218022884500_B1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/372143a0","article-title":"Chromosomal translocations in human cancer.","volume":"372","author":"Rabbitts","year":"1994","journal-title":"Nature."},{"key":"2020021218022884500_B2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.278.5340.1059","article-title":"Oncogenic transcription factors in the human acute leukemias.","volume":"278","author":"Look","year":"1997","journal-title":"Science."},{"key":"2020021218022884500_B3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1182\/blood.V81.2.293.293","article-title":"Topographical dissociation of BCL-2 messenger RNA and protein expression in human lymphoid tissues.","volume":"81","author":"Chleq-Deschamps","year":"1993","journal-title":"Blood."},{"key":"2020021218022884500_B4","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1182\/blood.V80.8.2044.2044","article-title":"Detection of bcl-2 protein and bcl-2 messenger RNA in normal and neoplastic lymphoid tissues by immunohistochemistry and in situ hybridization.","volume":"80","author":"Kondo","year":"1992","journal-title":"Blood."},{"key":"2020021218022884500_B5","first-page":"131","article-title":"Discordant regulation of SCL\/TAL-1 mRNA and protein during erythroid differentiation.","volume":"11","author":"Murrell","year":"1995","journal-title":"Oncogene."},{"key":"2020021218022884500_B6","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1073\/pnas.83.14.5214","article-title":"Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.","volume":"83","author":"Tsujimoto","year":"1986","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021218022884500_B7","first-page":"225","article-title":"Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.","volume":"137","author":"Pezzella","year":"1990","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1084\/jem.169.3.833","article-title":"Expression of the neutrophil elastase gene during human bone marrow cell differentiation.","volume":"169","author":"Fouret","year":"1989","journal-title":"J Exp Med."},{"key":"2020021218022884500_B9","doi-asserted-by":"crossref","first-page":"9638","DOI":"10.1073\/pnas.88.21.9638","article-title":"PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma.","volume":"88","author":"Rosenberg","year":"1991","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021218022884500_B10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/00000478-199207000-00001","article-title":"Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular data.","volume":"16","author":"Banks","year":"1992","journal-title":"Am J Surg Pathol."},{"key":"2020021218022884500_B11","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group.","volume":"84","author":"Harris","year":"1994","journal-title":"Blood."},{"key":"2020021218022884500_B12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/gcc.2870080204","article-title":"Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies.","volume":"8","author":"Raynaud","year":"1993","journal-title":"Genes Chromosomes Cancer."},{"key":"2020021218022884500_B13","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1182\/blood.V83.12.3664.3664","article-title":"Splenic lymphoma with villous lymphocytes: analysis of BCL-1 rearrangements and expression of the cyclin D1 gene.","volume":"83","author":"Jadayel","year":"1994","journal-title":"Blood."},{"key":"2020021218022884500_B14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/path.1711720303","article-title":"Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein.","volume":"172","author":"Bartkova","year":"1994","journal-title":"J Pathol."},{"key":"2020021218022884500_B15","first-page":"86","article-title":"Cyclin D1 (Bcl-1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia.","volume":"145","author":"Yang","year":"1994","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B16","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1101\/gad.7.5.812","article-title":"Cyclin D1 is a nuclear protein required for cell cycle progression in G1.","volume":"7","author":"Baldin","year":"1993","journal-title":"Genes Dev."},{"key":"2020021218022884500_B17","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1349-7006.1994.tb02969.x","article-title":"Monoclonal antibody against PRAD1\/cyclin D1 stains nuclei of tumor cells with translocation or amplification at BCL-1 locus.","volume":"85","author":"Banno","year":"1994","journal-title":"Jpn J Cancer Res."},{"key":"2020021218022884500_B18","first-page":"707","article-title":"Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines.","volume":"9","author":"Lukas","year":"1994","journal-title":"Oncogene."},{"key":"2020021218022884500_B19","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1365-2559.1999.00662.x","article-title":"Reliable immunostaining of cyclin D1 is difficult, but the problems can be overcome.","volume":"34","author":"Chan","year":"1999","journal-title":"Histopathology."},{"key":"2020021218022884500_B20","first-page":"268","article-title":"Optimizing cyclin D1 immunostaining of mantle cell lymphoma.","volume":"34","author":"Miller","year":"1999","journal-title":"Histopathology."},{"key":"2020021218022884500_B21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00129039-200003000-00009","article-title":"Optimized cyclin D1 immunoperoxidase staining in mantle cell lymphoma.","volume":"8","author":"Korin","year":"2000","journal-title":"Appl Immunohistochem Mol Morphol."},{"key":"2020021218022884500_B22","first-page":"1401","article-title":"Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation.","volume":"7","author":"Seto","year":"1992","journal-title":"Oncogene."},{"key":"2020021218022884500_B23","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1200\/JCO.1997.15.4.1664","article-title":"Mantle cell lymphoma: correlation of clinical outcome and biologic features with three histologic variants.","volume":"15","author":"Majlis","year":"1997","journal-title":"J Clin Oncol."},{"key":"2020021218022884500_B24","first-page":"536","article-title":"Immunostaining of PRAD1\/cyclin D1 protein as a marker for the diagnosis of mantle cell lymphoma.","volume":"3","author":"Nakamura","year":"1997","journal-title":"Leukemia."},{"key":"2020021218022884500_B25","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/S0002-9440(10)65710-0","article-title":"Differential expression of cyclin D1 in mantle cell lymphoma and other non-Hodgkin's lymphomas.","volume":"153","author":"Aguilera","year":"1998","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B26","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1182\/blood.V89.4.1421","article-title":"Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones.","volume":"89","author":"Ott","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2559.1994.tb00533.x","article-title":"The anaplastic variant of centrocytic lymphoma is marked by frequent rearrangements of the bcl-1 gene and high proliferation indices.","volume":"24","author":"Ott","year":"1994","journal-title":"Histopathology."},{"key":"2020021218022884500_B28","first-page":"810","article-title":"BCL-1 (PRAD-1\/cyclin D-1) overexpression distinguishes the blastoid variant of mantle cell lymphoma from B-lineage lymphoblastic lymphoma.","volume":"10","author":"Soslow","year":"1997","journal-title":"Mod Pathol."},{"key":"2020021218022884500_B29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/ajcp\/100.4.373","article-title":"Diffuse low-grade B-cell lymphomas. Four clinically distinct subtypes defined by a combination of morphologic and immunophenotypic features.","volume":"100","author":"Zukerberg","year":"1993","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B30","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/oxfordjournals.annonc.a058904","article-title":"European Lymphoma Task Force (ELTF): report of the workshop on mantle cell lymphoma (MCL).","volume":"5","author":"Zucca","year":"1994","journal-title":"Ann Oncol."},{"key":"2020021218022884500_B31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1309\/4W8E-8F4K-BHUP-UBE7","article-title":"The (11;14)(q13;q32) translocation in multiple myeloma. A morphologic and immunohistochemical study.","volume":"113","author":"Hoyer","year":"2000","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B32","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0002-9440(10)65022-5","article-title":"Immunohistochemical analysis of cyclin D1 shows deregulated expression in multiple myeloma with the t(11;14).","volume":"156","author":"Pruneri","year":"2000","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B33","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1182\/blood.V84.8.2726.2726","article-title":"PRAD-1\/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma.","volume":"84","author":"Bosch","year":"1994","journal-title":"Blood."},{"key":"2020021218022884500_B34","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/modpathol.3880239","article-title":"Immunohistochemical detection of cyclin D1 using optimized conditions is highly specific for mantle cell lymphoma and hairy cell leukemia.","volume":"13","author":"Miranda","year":"2000","journal-title":"Mod Pathol."},{"key":"2020021218022884500_B35","first-page":"601","article-title":"Absence of cyclin D1 protein expression in splenic marginal zone lymphoma.","volume":"11","author":"Savilo","year":"1998","journal-title":"Mod Pathol."},{"key":"2020021218022884500_B36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1440-1827.1997.tb04519.x","article-title":"Cyclin D1 overexpression in malignant lymphomas.","volume":"47","author":"Nakamura","year":"1997","journal-title":"Pathol Int."},{"key":"2020021218022884500_B37","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1182\/blood.V89.6.2067","article-title":"Mantle cell lymphoma: a clinicopathologic study of 80 cases.","volume":"89","author":"Argatoff","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B38","first-page":"2253","article-title":"Significance of cyclin D1 overexpression for the diagnosis of mantle cell lymphoma: a clinicopathologic comparison of cyclin D1-positive MCL and cyclin D1-negative MCL-like B-cell lymphoma.","volume":"95","author":"Yatabe","year":"2000","journal-title":"Blood."},{"key":"2020021218022884500_B39","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/sj.leu.2401470","article-title":"Cyclin D1 overexpression allows identification of an aggressive subset of leukemic lymphoproliferative disorder.","volume":"13","author":"Levy","year":"1999","journal-title":"Leukemia."},{"key":"2020021218022884500_B40","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/(SICI)1097-0142(19990901)86:5<850::AID-CNCR22>3.0.CO;2-Z","article-title":"Mantle cell lymphoma in leukemic phase: characterization of its broad cytologic spectrum with emphasis on the importance of distinction from other chronic lymphoproliferative disorders.","volume":"86","author":"Wong","year":"1999","journal-title":"Cancer."},{"key":"2020021218022884500_B41","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1182\/blood.V88.2.386.bloodjournal882386","article-title":"Molecular thanatopsis: a discourse on the BCL2 family and cell death.","volume":"88","author":"Yang","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B42","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.1073\/pnas.88.16.6961","article-title":"BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.","volume":"88","author":"Hockenbery","year":"1991","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021218022884500_B43","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/348334a0","article-title":"Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.","volume":"348","author":"Hockenbery","year":"1990","journal-title":"Nature."},{"key":"2020021218022884500_B44","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/cimm.1994.1127","article-title":"Bcl-2 expression in the thymus and periphery.","volume":"155","author":"Fujii","year":"1994","journal-title":"Cell Immunol."},{"key":"2020021218022884500_B45","first-page":"515","article-title":"Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.","volume":"145","author":"Krajewski","year":"1994","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B46","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1699-0463.1995.tb01419.x","article-title":"Bcl-2 oncoprotein is widespread in lymphoid tissue and lymphomas but its differential expression in benign versus malignant follicles and monocytoid B-cell proliferations is of diagnostic value.","volume":"103","author":"Wang","year":"1995","journal-title":"APMIS."},{"key":"2020021218022884500_B47","first-page":"1089","article-title":"Expression of the bcl-2 gene product in follicular lymphoma.","volume":"140","author":"Gaulard","year":"1992","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B48","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/0140-6736(90)93216-C","article-title":"Bcl-2 protein expression in follicular lymphomas in absence of 14;18 translocation [letter].","volume":"336","author":"Pezzella","year":"1990","journal-title":"Lancet."},{"key":"2020021218022884500_B49","first-page":"410","article-title":"BCL2 gene activation and protein expression in follicular lymphoma: a report on 64 cases.","volume":"7","author":"Seite","year":"1993","journal-title":"Leukemia."},{"key":"2020021218022884500_B50","first-page":"1834","article-title":"Follicular center cell lymphoma with the t(14;18) translocation in which the rearranged BCL-2 gene is silent.","volume":"7","author":"Wang","year":"1993","journal-title":"Leukemia."},{"key":"2020021218022884500_B51","first-page":"989","article-title":"Different bcl-2 protein expression in high-grade B-cell lymphomas derived from lymph node or mucosa-associated lymphoid tissue.","volume":"139","author":"Villuendas","year":"1991","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B52","first-page":"1456","article-title":"Bcl-2 protein in centrocytic lymphoma; a paraffin section study.","volume":"7","author":"Swerdlow","year":"1993","journal-title":"Leukemia."},{"key":"2020021218022884500_B53","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01757343","article-title":"High expression of bcl-2 is the rule in acute lymphoblastic leukemia, except in Burkitt subtype at presentation, and is not correlated with the prognosis.","volume":"69","author":"Gala","year":"1994","journal-title":"Ann Hematol."},{"key":"2020021218022884500_B54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1200\/JCO.1994.12.1.149","article-title":"Clinical significance of bcl-2-MBR gene rearrangement and protein expression in diffuse large-cell non-Hodgkin's lymphoma: an analysis of 83 cases.","volume":"12","author":"Tang","year":"1994","journal-title":"J Clin Oncol."},{"key":"2020021218022884500_B55","first-page":"1191","article-title":"Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia.","volume":"9","author":"Porwit-MacDonald","year":"1995","journal-title":"Leukemia."},{"key":"2020021218022884500_B56","first-page":"177","article-title":"Immunodetection of apoptosis-regulating proteins in lymphomas from patients with and without human immunodeficiency virus infection.","volume":"149","author":"Schlaifer","year":"1996","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B57","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<145::AID-PATH819>3.0.CO;2-P","article-title":"Cellular kinetic and phenotypic heterogeneity in and among Burkitt's and Burkitt-like lymphomas.","volume":"182","author":"Spina","year":"1997","journal-title":"J Pathol."},{"key":"2020021218022884500_B58","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0002-9440(10)61724-5","article-title":"Differential expression of bcl-2 family proteins in ALK-positive and ALK-negative anaplastic large cell lymphoma of T\/null-cell lineage.","volume":"159","author":"Rassidakis","year":"2001","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B59","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/S0002-9440(10)64146-6","article-title":"Bcl-2 expression in anaplastic large cell lymphoma.","volume":"158","author":"Villalva","year":"2001","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B60","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1440-1827.1997.tb03726.x","article-title":"Apoptosis and proliferative activity of non-Hodgkin's lymphomas: comparison with expression of bcl-2, p53 and c-myc proteins.","volume":"47","author":"Takano","year":"1997","journal-title":"Pathol Int."},{"key":"2020021218022884500_B61","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1046\/j.1365-2559.1997.d01-573.x","article-title":"Proliferation and apoptosis in primary gastric B-cell non-Hodgkin's lymphoma.","volume":"30","author":"Gisbertz","year":"1997","journal-title":"Histopathology."},{"key":"2020021218022884500_B62","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH733>3.0.CO;2-U","article-title":"Significantly different bcl-2 expression profiles in gastric and non-gastric primary extranodal high-grade B-cell lymphomas.","volume":"192","author":"Cogliatti","year":"2000","journal-title":"J Pathol."},{"key":"2020021218022884500_B63","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2559.1995.tb00624.x","article-title":"Heterogeneity of bcl-2 expression in MALT lymphoma.","volume":"26","author":"Ashton-Key","year":"1995","journal-title":"Histopathology."},{"key":"2020021218022884500_B64","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/jcp.48.1.18","article-title":"Expression of the bcl-2 protein in B cell lymphomas arising from mucosa-associated lymphoid tissue.","volume":"48","author":"Navratil","year":"1995","journal-title":"J Clin Pathol."},{"key":"2020021218022884500_B65","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/ajcp\/99.5.604","article-title":"bcl-2 expression in Hodgkin's disease. Correlation with the t(14;18) translocation and Epstein-Barr virus.","volume":"99","author":"Bhagat","year":"1993","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B66","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/ajcp\/99.6.663","article-title":"An immunocytochemical study of p53 and bcl-2 protein expression in Hodgkin's disease.","volume":"99","author":"Doussis","year":"1993","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B67","first-page":"1337","article-title":"The t(14;18) chromosomal translocation and Bcl-2 protein expression in Hodgkin's disease.","volume":"8","author":"Gupta","year":"1994","journal-title":"Leukemia."},{"key":"2020021218022884500_B68","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1182\/blood.V83.1.223.223","article-title":"The bcl-2 oncogene in Hodgkin's disease arising in the setting of follicular non-Hodgkin's lymphoma.","volume":"83","author":"Le Brun","year":"1994","journal-title":"Blood."},{"key":"2020021218022884500_B69","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2559.1991.tb00896.x","article-title":"Lymphocyte predominance Hodgkin's disease (nodular paragranuloma)\u2014a bcl-2 negative germinal centre lymphoma.","volume":"19","author":"Algara","year":"1991","journal-title":"Histopathology."},{"key":"2020021218022884500_B70","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/ajcp\/102.4.464","article-title":"Bcl-2 oncogene protein is preferentially expressed in Reed-Sternberg cells in Hodgkin's disease of the nodular sclerosis subtype.","volume":"102","author":"Lones","year":"1994","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B71","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/0046-8177(93)90209-Y","article-title":"Distinction of follicular hyperplasia from follicular lymphoma in B5-fixed tissues: comparison of MT2 and bcl-2 antibodies.","volume":"24","author":"Utz","year":"1993","journal-title":"Hum Pathol."},{"key":"2020021218022884500_B72","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2559.1994.tb00553.x","article-title":"Proliferation centres in B-cell malignant lymphoma, lymphocytic (B-CLL): an immunophenotypic study.","volume":"24","author":"Schmid","year":"1994","journal-title":"Histopathology."},{"key":"2020021218022884500_B73","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2559.1995.tb00628.x","article-title":"What is the value of bcl-2 protein detection for histopathologists?","volume":"26","author":"Pezzella","year":"1995","journal-title":"Histopathology."},{"key":"2020021218022884500_B74","first-page":"268","article-title":"Bcl-2 gene rearrangements in primary B-cell lymphoma of the gastrointestinal tract reveal follicular lymphoma as a subtype.","volume":"7","author":"Straka","year":"1993","journal-title":"Leukemia."},{"key":"2020021218022884500_B75","first-page":"560","article-title":"Staining for Bcl-2 protein helps to distinguish benign from malignant lymphoid aggregates in bone marrow biopsies.","volume":"7","author":"Ben-Ezra","year":"1994","journal-title":"Mod Pathol."},{"key":"2020021218022884500_B76","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/jcp.48.11.1035","article-title":"Immunohistochemistry in apparently normal bone marrow trephine specimens from patients with nodal follicular lymphoma.","volume":"48","author":"Chetty","year":"1995","journal-title":"J Clin Pathol."},{"key":"2020021218022884500_B77","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/S0046-8177(97)90254-9","article-title":"MIC2, TdT, bcl-2, and CD34 expression in paraffin-embedded high-grade lymphoma\/acute lymphoblastic leukemia distinguishes between distinct clinicopathologic entities.","volume":"28","author":"Soslow","year":"1997","journal-title":"Hum Pathol."},{"key":"2020021218022884500_B78","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.iy.13.040195.002501","article-title":"Regulation of lymphocyte survival by the bcl-2 gene family.","volume":"13","author":"Cory","year":"1995","journal-title":"Annu Rev Immunol."},{"key":"2020021218022884500_B79","first-page":"9","article-title":"Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies.","volume":"34","author":"Reed","year":"1997","journal-title":"Semin Hematol."},{"key":"2020021218022884500_B80","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1182\/blood.V87.1.265.265","article-title":"Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma. Groupe d'Etude des Lymphomes de l'Adulte (GELA).","volume":"87","author":"Hermine","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B81","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1182\/blood.V88.3.1046.1046","article-title":"Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study.","volume":"88","author":"Hill","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B82","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1200\/JCO.1996.14.7.2131","article-title":"Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study.","volume":"14","author":"Kramer","year":"1996","journal-title":"J Clin Oncol."},{"key":"2020021218022884500_B83","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1182\/blood.V90.1.244","article-title":"Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma.","volume":"90","author":"Gascoyne","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B84","first-page":"364","article-title":"Prognostic significance of t(14;18) and bcl-2 gene expression in follicular small cleaved cell lymphoma and diffuse large cell lymphoma.","volume":"20","author":"Martinka","year":"1997","journal-title":"Clin Invest Med."},{"key":"2020021218022884500_B85","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1200\/JCO.1998.16.5.1931","article-title":"Clinical outcome in diffuse large B-cell lymphoma is dependent on the relationship between different cell-cycle regulator proteins.","volume":"16","author":"Sanchez","year":"1998","journal-title":"J Clin Oncol."},{"key":"2020021218022884500_B86","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00001622-199909000-00006","article-title":"Recent advances in the molecular pathogenesis of lymphomas.","volume":"11","author":"Sarris","year":"1999","journal-title":"Curr Opin Oncol."},{"key":"2020021218022884500_B87","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1182\/blood.V81.11.3091.3091","article-title":"High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy.","volume":"81","author":"Campos","year":"1993","journal-title":"Blood."},{"key":"2020021218022884500_B88","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2141.1994.tb04984.x","article-title":"The relationship between bcl-2 expression and response to chemotherapy in acute leukaemia.","volume":"88","author":"Maung","year":"1994","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B89","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1038\/sj.leu.2400854","article-title":"High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate.","volume":"11","author":"Lauria","year":"1997","journal-title":"Leukemia."},{"key":"2020021218022884500_B90","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF03401913","article-title":"Ratio of bcl-xshort to bcl-xlong is different in good- and poor-prognosis subsets of acute myeloid leukemia.","volume":"4","author":"Deng","year":"1998","journal-title":"Mol Med."},{"key":"2020021218022884500_B91","first-page":"1758","article-title":"The prognostic impact of BCL2 protein expression in acute myelogenous leukemia varies with cytogenetics.","volume":"5","author":"Kornblau","year":"1999","journal-title":"Clin Cancer Res."},{"key":"2020021218022884500_B92","first-page":"376","article-title":"Low p53 and high bcl-2 expression in Reed-Sternberg cells predicts poor clinical outcome for Hodgkin's disease: involvement of apoptosis resistance?","volume":"11","author":"Brink","year":"1998","journal-title":"Mod Pathol."},{"key":"2020021218022884500_B93","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1200\/JCO.1997.15.4.1654","article-title":"Follicular large-cell lymphoma treated with intensive chemotherapy: an analysis of 89 cases included in the LNH87 trial and comparison with the outcome of diffuse large B-cell lymphoma. Groupe d'Etude des Lymphomes de l'Adulte.","volume":"15","author":"Wendum","year":"1997","journal-title":"J Clin Oncol."},{"key":"2020021218022884500_B94","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1182\/blood.V93.9.3081","article-title":"Correlation of bcl-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphoma.","volume":"93","author":"Lopez-Guillermo","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B95","first-page":"456","article-title":"Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome.","volume":"10","author":"Robertson","year":"1996","journal-title":"Leukemia."},{"key":"2020021218022884500_B96","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2141.1997.3353152.x","article-title":"Fludarabine ability to down-regulate Bcl-2 gene product in CD5+ leukaemic B cells: in vitro\/in vivo correlations.","volume":"99","author":"Gottardi","year":"1997","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B97","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1182\/blood.V87.3.1140.bloodjournal8731140","article-title":"Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia.","volume":"87","author":"Coustan-Smith","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B98","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1182\/blood.V89.10.3769","article-title":"Cellular expression of antiapoptotic BCL-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia: a Children's Cancer Group Study.","volume":"89","author":"Uckun","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B99","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/sj.leu.2401529","article-title":"Bcl-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome.","volume":"13","author":"Salomons","year":"1999","journal-title":"Leukemia."},{"key":"2020021218022884500_B100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng0697-161","article-title":"The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation.","volume":"16","author":"Ye","year":"1997","journal-title":"Nat Genet."},{"key":"2020021218022884500_B101","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1084\/jem.192.12.1841","article-title":"Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.","volume":"192","author":"Reljic","year":"2000","journal-title":"J Exp Med."},{"key":"2020021218022884500_B102","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.8235596","article-title":"Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.","volume":"262","author":"Ye","year":"1993","journal-title":"Science."},{"key":"2020021218022884500_B103","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1182\/blood.V83.7.1757.1757","article-title":"Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma.","volume":"83","author":"Lo Coco","year":"1994","journal-title":"Blood."},{"key":"2020021218022884500_B104","first-page":"651","article-title":"Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia.","volume":"95","author":"Capello","year":"2000","journal-title":"Blood."},{"key":"2020021218022884500_B105","doi-asserted-by":"crossref","first-page":"11816","DOI":"10.1073\/pnas.95.20.11816","article-title":"BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.","volume":"95","author":"Pasqualucci","year":"1998","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021218022884500_B106","first-page":"1543","article-title":"Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region.","volume":"148","author":"Flenghi","year":"1996","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B107","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood.V86.1.45.bloodjournal86145","article-title":"BCL-6 protein is expressed in germinal-center B cells.","volume":"86","author":"Cattoretti","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B108","first-page":"405","article-title":"A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells.","volume":"147","author":"Flenghi","year":"1995","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B109","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1182\/blood.V86.1.28.bloodjournal86128","article-title":"BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts.","volume":"86","author":"Onizuka","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B110","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/annonc\/8.suppl_2.S101","article-title":"BCL-6 protein expression in normal and neoplastic lymphoid tissues.","volume":"8","author":"Falini","year":"1997","journal-title":"Ann Oncol."},{"key":"2020021218022884500_B111","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0046-8177(99)90115-6","article-title":"Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma.","volume":"30","author":"Ree","year":"1999","journal-title":"Hum Pathol."},{"key":"2020021218022884500_B112","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1182\/blood.V97.1.270","article-title":"BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus.","volume":"97","author":"Hyjek","year":"2001","journal-title":"Blood."},{"key":"2020021218022884500_B113","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1440-1827.1997.tb04548.x","article-title":"Expression of bcl-6 protein in normal skin and epidermal neoplasms.","volume":"47","author":"Kanazawa","year":"1997","journal-title":"Pathol Int."},{"key":"2020021218022884500_B114","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0046-8177(99)90141-7","article-title":"Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: correlation with 3q27 and 18q21 chromosomal abnormalities.","volume":"30","author":"Skinnider","year":"1999","journal-title":"Hum Pathol."},{"key":"2020021218022884500_B115","first-page":"155","article-title":"BCL-6 protein in AIDS-related non-Hodgkin's lymphomas: inverse relationship with Epstein-Barr virus-encoded latent membrane protein-1 expression.","volume":"150","author":"Carbone","year":"1997","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B116","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1056\/NEJM199911113412007","article-title":"Cellular origin of human B-cell lymphomas.","volume":"341","author":"Kuppers","year":"1999","journal-title":"N Engl J Med."},{"key":"2020021218022884500_B117","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1182\/blood.V90.6.2445","article-title":"BCL-6 protein expression in human peripheral T-cell neoplasms is restricted to CD30+ anaplastic large-cell lymphomas.","volume":"90","author":"Carbone","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B118","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1182\/blood.V87.2.465.bloodjournal872465","article-title":"Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease.","volume":"87","author":"Falini","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B119","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00000478-199405000-00014","article-title":"Nodular lymphocyte predominance Hodgkin's disease. A distinct clinicopathological entity.","volume":"18","author":"Mason","year":"1994","journal-title":"Am J Surg Pathol."},{"key":"2020021218022884500_B120","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/00000478-200006000-00010","article-title":"CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas.","volume":"24","author":"Dogan","year":"2000","journal-title":"Am J Surg Pathol."},{"key":"2020021218022884500_B121","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/ajcp\/112.1.101","article-title":"Bcl-6 protein expression by follicle center lymphomas. A marker for differentiating follicle center lymphomas from other low-grade lymphoproliferative disorders.","volume":"112","author":"Raible","year":"1999","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B122","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1097\/00000478-200008000-00004","article-title":"Lymphocyte predominance Hodgkin's disease: the use of bcl-6 and CD57 in diagnosis and differential diagnosis.","volume":"24","author":"Kraus","year":"2000","journal-title":"Am J Surg Pathol."},{"key":"2020021218022884500_B123","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng1097-226","article-title":"Deregulation of MUM1\/IRF4 by chromosomal translocation in multiple myeloma.","volume":"17","author":"Iida","year":"1997","journal-title":"Nat Genet."},{"key":"2020021218022884500_B124","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.275.5299.540","article-title":"Requirement for the transcription factor LSIRF\/IRF4 for mature B and T lymphocyte function.","volume":"275","author":"Mittrucker","year":"1997","journal-title":"Science."},{"key":"2020021218022884500_B125","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1182\/blood.V95.6.2084","article-title":"A monoclonal antibody (MUM1p) detects expression of the MUM1\/IRF4 protein in a subset of germinal center B cells, plasma cells and activated T cells.","volume":"95","author":"Falini","year":"2000","journal-title":"Blood."},{"key":"2020021218022884500_B126","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1365-2141.2000.02329.x","article-title":"Expression of MUM1\/IRF4 selectively clusters with primary effusion lymphoma among lymphomatous effusions: implications for disease histogenesis and pathogenesis.","volume":"111","author":"Carbone","year":"2000","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B127","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/sj.leu.2401748","article-title":"MUM1: a step ahead toward the understanding of lymphoma histogenesis [editorial].","volume":"14","author":"Gaidano","year":"2000","journal-title":"Leukemia."},{"key":"2020021218022884500_B128","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/sj.leu.2401696","article-title":"MUM1\/IRF4 expression as a frequent event in mature lymphoid malignancies.","volume":"14","author":"Tsuboi","year":"2000","journal-title":"Leukemia."},{"key":"2020021218022884500_B129","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/44076","article-title":"Commitment to the B-lymphoid lineage depends on the transcription factor Pax5.","volume":"401","author":"Nutt","year":"1999","journal-title":"Nature."},{"key":"2020021218022884500_B130","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1182\/blood.V88.11.4110.4110","article-title":"The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene.","volume":"88","author":"Iida","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B131","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1182\/blood.V92.4.1308","article-title":"Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas.","volume":"92","author":"Krenacs","year":"1998","journal-title":"Blood."},{"key":"2020021218022884500_B132","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1182\/blood.V94.9.3108","article-title":"Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin.","volume":"94","author":"Foss","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B133","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1182\/blood.V93.9.2760","article-title":"The SCL gene: from case report to critical hematopoietic regulator.","volume":"93","author":"Begley","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B134","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1182\/blood.V80.11.2858.bloodjournal80112858","article-title":"T-cell acute lymphoblastic leukemia\u2014the associated gene SCL\/tal codes for a 42-Kd nuclear phosphoprotein.","volume":"80","author":"Goldfarb","year":"1992","journal-title":"Blood."},{"key":"2020021218022884500_B135","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1101\/gad.12.4.473","article-title":"Unsuspected role for the T-cell leukemia protein SCL\/tal-1 in vascular development.","volume":"12","author":"Visvader","year":"1998","journal-title":"Genes Dev."},{"key":"2020021218022884500_B136","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/gcc.2870010303","article-title":"Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias.","volume":"1","author":"Bernard","year":"1990","journal-title":"Genes Chromosomes Cancer."},{"key":"2020021218022884500_B137","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1182\/blood.V85.3.675.bloodjournal853675","article-title":"Expression of TAL-1 proteins in human tissues.","volume":"85","author":"Pulford","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B138","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/hyb.1998.17.251","article-title":"Production and characterization of monoclonal antibodies against Tal1 oncoprotein.","volume":"17","author":"Hsu","year":"1998","journal-title":"Hybridoma."},{"key":"2020021218022884500_B139","first-page":"475","article-title":"Erythroid expression of the \u2018helix-loop-helix\u2019 gene, SCL.","volume":"6","author":"Green","year":"1991","journal-title":"Oncogene."},{"key":"2020021218022884500_B140","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.V83.5.1200.1200","article-title":"The SCL\/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis.","volume":"83","author":"Kallianpur","year":"1994","journal-title":"Blood."},{"key":"2020021218022884500_B141","first-page":"187","article-title":"Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system.","volume":"6","author":"Visvader","year":"1991","journal-title":"Oncogene."},{"key":"2020021218022884500_B142","first-page":"677","article-title":"Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues.","volume":"8","author":"Cheng","year":"1993","journal-title":"Oncogene."},{"key":"2020021218022884500_B143","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1182\/blood.V86.2.666.bloodjournal862666","article-title":"Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.","volume":"86","author":"Bash","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B144","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/1357-2725(96)00006-4","article-title":"The helix-loop-helix gene SCL: implicated in T-cell acute lymphoblastic leukaemia and in normal haematopoietic development.","volume":"28","author":"Robb","year":"1996","journal-title":"Int J Biochem Cell Biol."},{"key":"2020021218022884500_B145","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3109\/08880019709041594","article-title":"Transcription of tal-1, a putative oncogene playing an important role in childhood T-ALL, can be shown in normal peripheral blood cells by a highly sensitive RT-PCR assay.","volume":"14","author":"Anderegg","year":"1997","journal-title":"Pediatr Hematol Oncol."},{"key":"2020021218022884500_B146","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1365-2141.1998.00807.x","article-title":"TAL1 expression does not occur in the majority of T-ALL blasts.","volume":"102","author":"Delabesse","year":"1998","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B147","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1096-9896(199603)178:3<311::AID-PATH477>3.0.CO;2-B","article-title":"An immunohistochemical study of TAL-1 protein expression in leukaemias and lymphomas with a novel monoclonal antibody, 2TL 242.","volume":"178","author":"Chetty","year":"1996","journal-title":"J Pathol."},{"key":"2020021218022884500_B148","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1182\/blood.V81.8.2110.2110","article-title":"Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study.","volume":"81","author":"Bash","year":"1993","journal-title":"Blood."},{"key":"2020021218022884500_B149","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1182\/blood.V83.1.10.10","article-title":"Acute promyelocytic leukemia: from genetics to treatment.","volume":"83","author":"Grignani","year":"1994","journal-title":"Blood."},{"key":"2020021218022884500_B150","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/35018127","article-title":"PML regulates p53 acetylation and premature senescence induced by oncogenic Ras.","volume":"406","author":"Pearson","year":"2000","journal-title":"Nature."},{"key":"2020021218022884500_B151","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/35901","article-title":"Fusion proteins of the retinoic acid receptor-\u03b1 recruit histone deacetylase in promyelocytic leukaemia.","volume":"391","author":"Grignani","year":"1998","journal-title":"Nature."},{"key":"2020021218022884500_B152","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/35895","article-title":"Role of the histone deacetylase complex in acute promyelocytic leukaemia.","volume":"391","author":"Lin","year":"1998","journal-title":"Nature."},{"key":"2020021218022884500_B153","first-page":"472","article-title":"PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia.","volume":"81","author":"Pandolfi","year":"1996","journal-title":"Haematologica."},{"key":"2020021218022884500_B154","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1182\/blood.V85.7.1871.bloodjournal8571871","article-title":"Characterization of a new monoclonal antibody (PG-M3) directed against the amino-terminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia.","volume":"85","author":"Flenghi","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B155","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1242\/jcs.101.4.773","article-title":"A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies.","volume":"101","author":"Stuurman","year":"1992","journal-title":"J Cell Sci."},{"key":"2020021218022884500_B156","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/j.1460-2075.1994.tb06356.x","article-title":"The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.","volume":"13","author":"Koken","year":"1994","journal-title":"EMBO J."},{"key":"2020021218022884500_B157","first-page":"1083","article-title":"Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.","volume":"7","author":"Fagioli","year":"1992","journal-title":"Oncogene."},{"key":"2020021218022884500_B158","first-page":"1315","article-title":"The PML growth-suppressor has an altered expression in human oncogenesis.","volume":"10","author":"Koken","year":"1995","journal-title":"Oncogene."},{"key":"2020021218022884500_B159","first-page":"1590","article-title":"PML nuclear bodies are general targets for inflammation and cell proliferation.","volume":"55","author":"Terris","year":"1995","journal-title":"Cancer Res."},{"key":"2020021218022884500_B160","first-page":"2023","article-title":"Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues.","volume":"149","author":"Gambacorta","year":"1996","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B161","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1182\/blood.V82.6.1858.1858","article-title":"PML protein expression in hematopoietic and acute promyelocytic leukemia cells.","volume":"82","author":"Daniel","year":"1993","journal-title":"Blood."},{"key":"2020021218022884500_B162","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0092-8674(94)90341-7","article-title":"Retinoic acid regulates aberrant nuclear localization of PML-RAR \u03b1 in acute promyelocytic leukemia cells.","volume":"76","author":"Weis","year":"1994","journal-title":"Cell."},{"key":"2020021218022884500_B163","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1182\/blood.V85.12.3646.bloodjournal85123646","article-title":"The PML gene encodes a phosphoprotein associated with the nuclear matrix.","volume":"85","author":"Chang","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B164","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0092-8674(94)90340-9","article-title":"A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein.","volume":"76","author":"Dyck","year":"1994","journal-title":"Cell."},{"key":"2020021218022884500_B165","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1086\/301991","article-title":"Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies.","volume":"63","author":"Hodges","year":"1998","journal-title":"Am J Hum Genet."},{"key":"2020021218022884500_B166","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-4827(92)90068-J","article-title":"Nuclear bodies (NBs): a newly \u201crediscovered\u201d organelle.","volume":"202","author":"Brasch","year":"1992","journal-title":"Exp Cell Res."},{"key":"2020021218022884500_B167","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.112.5.785","article-title":"Identification of a novel nuclear domain.","volume":"112","author":"Ascoli","year":"1991","journal-title":"J Cell Biol."},{"key":"2020021218022884500_B168","first-page":"1123","article-title":"Prevalence, kinetics, and therapeutic modulation of autoantibodies against Sp100 and promyelocytic leukemia protein in a large cohort of patients with primary biliary cirrhosis.","volume":"26","author":"Zuchner","year":"1997","journal-title":"Hepatology."},{"key":"2020021218022884500_B169","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.130.1.1","article-title":"Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment.","volume":"130","author":"Korioth","year":"1995","journal-title":"J Cell Biol."},{"key":"2020021218022884500_B170","doi-asserted-by":"crossref","first-page":"29198","DOI":"10.1074\/jbc.271.46.29198","article-title":"Identification and characterization of a leukocyte-specific component of the nuclear body.","volume":"271","author":"Bloch","year":"1996","journal-title":"J Biol Chem."},{"key":"2020021218022884500_B171","first-page":"971","article-title":"PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.","volume":"13","author":"Boddy","year":"1996","journal-title":"Oncogene."},{"key":"2020021218022884500_B172","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1126\/science.273.5277.951","article-title":"Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-1 Tax oncoprotein.","volume":"273","author":"Desbois","year":"1996","journal-title":"Science."},{"key":"2020021218022884500_B173","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1083\/jcb.139.7.1621","article-title":"Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1\/SUMO-1.","volume":"139","author":"Sternsdorf","year":"1997","journal-title":"J Cell Biol."},{"key":"2020021218022884500_B174","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/emboj\/17.1.61","article-title":"Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.","volume":"17","author":"Mu\u0308ller","year":"1998","journal-title":"EMBO J."},{"key":"2020021218022884500_B175","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1182\/blood.V92.11.4308","article-title":"Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells.","volume":"92","author":"Mu\u0308ller","year":"1998","journal-title":"Blood."},{"key":"2020021218022884500_B176","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1182\/blood.V86.3.862.862","article-title":"Rapid diagnosis of acute promyelocytic leukemia by immunohistochemical localization of PML\/RAR-\u03b1 protein.","volume":"86","author":"Dyck","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B177","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1182\/blood.V90.10.4046","article-title":"Immunocytochemical diagnosis of acute promyelocytic leukemia (M3) with the monoclonal antibody PG-M3 (anti-PML).","volume":"90","author":"Falini","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B178","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1046\/j.1365-2141.1997.4613266.x","article-title":"The rapid diagnosis of acute promyelocytic leukaemia using PML (5E10) monoclonal antibody.","volume":"99","author":"O'Connor","year":"1997","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B179","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/ajcp\/109.2.205","article-title":"An immunofluorescent assay for acute promyelocytic leukemia cells.","volume":"109","author":"Samoszuk","year":"1998","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B180","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1309\/J6PU-3XY6-R0C3-NW26","article-title":"Rapid diagnosis of acute promyelocytic leukemia by analyzing the immunocytochemical pattern of the PML protein with the monoclonal antibody PG-M3.","volume":"114","author":"Villamor","year":"2000","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B181","first-page":"4876","article-title":"Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.","volume":"90","author":"Grimwade","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B182","first-page":"321a","article-title":"The t(5;17) APL fusion protein NPM-RAR does not alter PML localization [abstract].","volume":"90(suppl 1)","author":"Redner","year":"1997","journal-title":"Blood"},{"key":"2020021218022884500_B183","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/sj.onc.1202357","article-title":"Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia.","volume":"18","author":"Hummel","year":"1999","journal-title":"Oncogene."},{"key":"2020021218022884500_B184","first-page":"1297","article-title":"Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Francais de Cytogenetique Hematologique, Groupe de Francais d'Hematologie Cellulaire, UK Cancer Cytogenetics Group, and BIOMED 1 European Community-Concerted Action \u201cMolecular Cytogenetic Diagnosis in Haematological Malignancies.\u201d","volume":"96","author":"Grimwade","year":"2000","journal-title":"Blood."},{"key":"2020021218022884500_B185","volume-title":"Tumors of the Bone Marrow.","author":"Brunning","year":"1994"},{"key":"2020021218022884500_B186","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJM199710093371501","article-title":"All-trans-retinoic acid in acute promyelocytic leukemia.","volume":"337","author":"Tallman","year":"1997","journal-title":"N Engl J Med."},{"key":"2020021218022884500_B187","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1182\/blood.V94.1.12.413a44_12_22","article-title":"Genetic diagnosis and molecular monitoring in the management of acute promyelocytic leukemia.","volume":"94","author":"Lo Coco","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B188","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1182\/blood.V89.9.3354","article-title":"Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients.","volume":"89","author":"Shen","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B189","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1182\/blood.V85.4.1083.bloodjournal8541083","article-title":"Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).","volume":"85","author":"Licht","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B190","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/j.1460-2075.1993.tb05757.x","article-title":"Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-\u03b1 locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.","volume":"12","author":"Chen","year":"1993","journal-title":"EMBO J."},{"key":"2020021218022884500_B191","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1182\/blood.V87.3.882.bloodjournal873882","article-title":"The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.","volume":"87","author":"Redner","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B192","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/ng0997-109","article-title":"Fusion of retinoic acid receptor \u03b1 to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia.","volume":"17","author":"Wells","year":"1997","journal-title":"Nat Genet."},{"key":"2020021218022884500_B193","first-page":"323","article-title":"Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-\u03b1 chimera generated in t(11;17)-associated acute promyelocytic leukemia.","volume":"12","author":"Licht","year":"1996","journal-title":"Oncogene."},{"key":"2020021218022884500_B194","doi-asserted-by":"crossref","first-page":"10255","DOI":"10.1073\/pnas.94.19.10255","article-title":"Leukemia-associated retinoic acid receptor \u03b1 fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies.","volume":"94","author":"Koken","year":"1997","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021218022884500_B195","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.onc.1201722","article-title":"The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies.","volume":"16","author":"Ruthardt","year":"1998","journal-title":"Oncogene."},{"key":"2020021218022884500_B196","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1182\/blood.V86.12.4544.bloodjournal86124544","article-title":"Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors.","volume":"86","author":"Reid","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B197","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1073\/pnas.92.6.2249","article-title":"Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain.","volume":"92","author":"Cook","year":"1995","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021218022884500_B198","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1182\/blood.V73.3.806.806","article-title":"A novel translocation, t(2;5)(p23;q35), in childhood phagocytic large T-cell lymphoma mimicking malignant histiocytosis.","volume":"73","author":"Kaneko","year":"1989","journal-title":"Blood."},{"key":"2020021218022884500_B199","first-page":"866","article-title":"The t(2;5)(p23;q35): a recurring chromosomal abnormality in Ki-1-positive anaplastic large cell lymphoma.","volume":"3","author":"Le Beau","year":"1989","journal-title":"Leukemia."},{"key":"2020021218022884500_B200","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2141.1990.tb02560.x","article-title":"CD30-positive large cell lymphomas (\u2018Ki-1 lymphoma\u2019) are associated with a chromosomal translocation involving 5q35.","volume":"74","author":"Mason","year":"1990","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B201","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.8122112","article-title":"Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.","volume":"263","author":"Morris","year":"1994","journal-title":"Science."},{"key":"2020021218022884500_B202","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/sj.onc.1201062","article-title":"ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural-specific receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).","volume":"14","author":"Morris","year":"1997","journal-title":"Oncogene."},{"key":"2020021218022884500_B203","first-page":"1567","article-title":"Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3.","volume":"9","author":"Shiota","year":"1994","journal-title":"Oncogene."},{"key":"2020021218022884500_B204","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1073\/pnas.93.9.4181","article-title":"Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).","volume":"93","author":"Fujimoto","year":"1996","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021218022884500_B205","first-page":"59","article-title":"The NPM\/ALK gene fusion in the pathogenesis of anaplastic large cell lymphoma.","volume":"30","author":"Ladanyi","year":"1997","journal-title":"Cancer Surv"},{"key":"2020021218022884500_B206","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/sj.leu.2401878","article-title":"Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas.","volume":"14","author":"Drexler","year":"2000","journal-title":"Leukemia."},{"key":"2020021218022884500_B207","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0002-9440(10)64945-0","article-title":"ATIC-ALK: a novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).","volume":"156","author":"Colleoni","year":"2000","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B208","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1182\/blood.V93.9.3088","article-title":"A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2) (q25;p23) translocation.","volume":"93","author":"Lamant","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B209","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1182\/blood.V95.6.2144","article-title":"Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis.","volume":"95","author":"Ma","year":"2000","journal-title":"Blood."},{"key":"2020021218022884500_B210","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1182\/blood.V95.10.3204","article-title":"Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like).","volume":"95","author":"Touriol","year":"2000","journal-title":"Blood."},{"key":"2020021218022884500_B211","first-page":"793","article-title":"A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC- ALK) in a case of ALK-positive anaplastic large cell lymphoma.","volume":"60","author":"Trinei","year":"2000","journal-title":"Cancer Res."},{"key":"2020021218022884500_B212","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/labinvest.3780249","article-title":"Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma.","volume":"81","author":"Tort","year":"2001","journal-title":"Lab Invest."},{"key":"2020021218022884500_B213","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1182\/blood.V98.4.1209","article-title":"Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4-anaplastic lymphoma kinase gene fusion.","volume":"98","author":"Meech","year":"2001","journal-title":"Blood."},{"key":"2020021218022884500_B214","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1182\/blood.V85.12.3416.bloodjournal85123416","article-title":"Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction.","volume":"85","author":"Downing","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B215","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1182\/blood.V86.9.3517.bloodjournal8693517","article-title":"Transcripts of the npm-alk fusion gene in anaplastic large cell lymphoma, Hodgkin's disease, and reactive lymphoid lesions.","volume":"86","author":"Elmberger","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B216","first-page":"323","article-title":"Low frequency association of the t(2;5)(p23;q35) chromosomal translocation with CD30+ lymphomas from American and Asian patients. A reverse transcriptase-polymerase chain reaction study.","volume":"146","author":"Lopategui","year":"1995","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B217","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1182\/blood.V86.6.2321.bloodjournal8662321","article-title":"Analysis of the t(2;5)(p23;q35) translocation by reverse transcription-polymerase chain reaction in CD30+ anaplastic large-cell lymphomas, in other non-Hodgkin's lymphomas of T-cell phenotype, and in Hodgkin's disease.","volume":"86","author":"Wellmann","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B218","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1182\/blood.V87.8.3437.bloodjournal8783437","article-title":"The t(2;5) chromosomal translocation is not a common feature of primary cutaneous CD30+ lymphoproliferative disorders: comparison with anaplastic large-cell lymphoma of nodal origin.","volume":"87","author":"DeCoteau","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B219","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1182\/blood.V87.1.284.284","article-title":"High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and P-80 immunostaining.","volume":"87","author":"Lamant","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B220","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1182\/blood.V84.11.3648.bloodjournal84113648","article-title":"Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry.","volume":"84","author":"Shiota","year":"1994","journal-title":"Blood."},{"key":"2020021218022884500_B221","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1182\/blood.V86.5.1954.bloodjournal8651954","article-title":"Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM\/ALK: a distinct clinicopathologic entity.","volume":"86","author":"Shiota","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B222","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1097\/00000478-199712000-00004","article-title":"Anaplastic large cell lymphoma: a distinct molecular pathologic entity: a reappraisal with special reference to p80(NPM\/ALK) expression.","volume":"21","author":"Nakamura","year":"1997","journal-title":"Am J Surg Pathol."},{"key":"2020021218022884500_B223","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1182\/blood.V86.5.1694.bloodjournal8651694","article-title":"ALK gene products in anaplastic large cell lymphomas and Hodgkin's disease.","volume":"86","author":"Herbst","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B224","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1182\/blood.V87.3.1081.bloodjournal8731081","article-title":"Molecular characterization of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease.","volume":"87","author":"Yee","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B225","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/MCB.17.4.2312","article-title":"Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis.","volume":"17","author":"Bischof","year":"1997","journal-title":"Mol Cell Biol."},{"key":"2020021218022884500_B226","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/annonc\/8.suppl_1.S37","article-title":"Use of an anti-ALK antibody in the characterization of anaplastic large-cell lymphoma of childhood.","volume":"8(suppl 1)","author":"Hutchison","year":"1997","journal-title":"Ann Oncol."},{"key":"2020021218022884500_B227","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1182\/blood.V89.4.1394","article-title":"Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK protein in normal and neoplastic cells with the monoclonal antibody ALK1.","volume":"89","author":"Pulford","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B228","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0002-9440(10)65629-5","article-title":"ALK expression defines a distinct group of T\/null lymphoma (\u201cALK lymphoma\u201d) with a wide morphological spectrum.","volume":"153","author":"Falini","year":"1998","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B229","first-page":"1207","article-title":"Frequent expression of the NPM-ALK chimeric fusion protein in anaplastic large-cell lymphoma, lympho-histiocytic type.","volume":"150","author":"Pileri","year":"1997","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B230","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1182\/blood.V91.6.2076","article-title":"ALK-positive lymphoma: a single disease with a broad spectrum of morphology.","volume":"91","author":"Benharroch","year":"1998","journal-title":"Blood."},{"key":"2020021218022884500_B231","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0014-4827(83)90332-4","article-title":"Localization of nucleolar phosphoproteins B23 and C23 during mitosis.","volume":"146","author":"Ochs","year":"1983","journal-title":"Exp Cell Res."},{"key":"2020021218022884500_B232","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1182\/blood.V93.2.632","article-title":"Detection of normal and chimeric nucleophosmin in human cells.","volume":"93","author":"Cordell","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B233","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1046\/j.1365-2141.1998.01097.x","article-title":"Detection of the t(2;5)-associated NPM\/ALK fusion cDNA in peripheral blood cells of healthy individuals.","volume":"103","author":"Trumper","year":"1998","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B234","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/S0002-9440(10)64690-1","article-title":"The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells.","volume":"158","author":"Maes","year":"2001","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B235","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0002-9440(10)65042-0","article-title":"Expression of the ALK tyrosine kinase gene in neuroblastoma.","volume":"156","author":"Lamant","year":"2000","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B236","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1182\/blood.V96.12.3681","article-title":"CD30+ anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features.","volume":"96","author":"Stein","year":"2000","journal-title":"Blood."},{"key":"2020021218022884500_B237","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2141.2001.02896.x","article-title":"Anaplastic large cell lymphoma: pathological, molecular and clinical features.","volume":"114","author":"Falini","year":"2001","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B238","first-page":"3509","article-title":"Lymphomas expressing ALK fusion protein(s) other than NPM-ALK.","volume":"94","author":"Falini","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B239","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0002-9440(10)65421-1","article-title":"Biochemical detection of novel ALK proteins in tissue sections of anaplastic large cell lymphoma.","volume":"154","author":"Pulford","year":"1999","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B240","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00125480-199809000-00002","article-title":"Anaplastic large cell lymphoma: redefining its morphologic spectrum and importance of recognition of the ALK-positive subset.","volume":"5","author":"Chan","year":"1998","journal-title":"Adv Anat Pathol."},{"issue":"1 suppl 1","key":"2020021218022884500_B241","first-page":"S56","article-title":"The pathologic and clinical spectrum of anaplastic large cell lymphoma and correlation with ALK gene dysregulation.","volume":"111","author":"Kinney","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"2020021218022884500_B242","first-page":"343","article-title":"The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23\/ALK rearrangements.","volume":"151","author":"Pittaluga","year":"1997","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B243","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/00000478-199010000-00013","article-title":"Sarcomatoid variant of anaplastic large-cell Ki-1 lymphoma.","volume":"14","author":"Chan","year":"1990","journal-title":"Am J Surg Pathol."},{"key":"2020021218022884500_B244","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-2559.1990.tb01143.x","article-title":"Lymphohistiocytic T-cell lymphoma (anaplastic large cell lymphoma CD30+\/Ki-1+ with a high content of reactive histiocytes).","volume":"16","author":"Pileri","year":"1990","journal-title":"Histopathology."},{"key":"2020021218022884500_B245","first-page":"77","article-title":"Anaplastic large cell lymphoma and its morphological variants.","volume":"30","author":"Kadin","year":"1997","journal-title":"Cancer Surv."},{"key":"2020021218022884500_B246","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1600-0560.1997.tb00814.x","article-title":"The pathogenesis of large cell transformation in cutaneous T-cell lymphoma is not associated with t(2;5)(p23;q35) chromosomal translocation.","volume":"24","author":"Li","year":"1997","journal-title":"J Cutan Pathol."},{"key":"2020021218022884500_B247","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/00000478-199309000-00001","article-title":"A small-cell-predominant variant of primary Ki-1 (CD30)+ T-cell lymphoma.","volume":"17","author":"Kinney","year":"1993","journal-title":"Am J Surg Pathol."},{"key":"2020021218022884500_B248","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1046\/j.1365-2141.1999.01238.x","article-title":"Leukaemic presentation of small cell variant anaplastic large cell lymphoma: report of four cases.","volume":"104","author":"Bayle","year":"1999","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B249","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0344-0338(99)80132-0","article-title":"Bone marrow involvement in NPM-ALK-positive lymphoma: report of two cases.","volume":"195","author":"Sadahira","year":"1999","journal-title":"Pathol Res Pract."},{"key":"2020021218022884500_B250","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1182\/blood.V89.3.980","article-title":"Cytotoxic cell antigen expression in anaplastic large cell lymphomas of T- and null-cell type and Hodgkin's disease: evidence for distinct cellular origin.","volume":"89","author":"Krenacs","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B251","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1046\/j.1365-2141.2000.02045.x","article-title":"Anaplastic large-cell lymphomas of B-cell phenotype are anaplastic lymphoma kinase (ALK) negative and belong to the spectrum of diffuse large B-cell lymphomas.","volume":"109","author":"Haralambieva","year":"2000","journal-title":"Br J Haematol."},{"key":"2020021218022884500_B252","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1365-2133.1997.tb01101.x","article-title":"Absence of anaplastic lymphoma kinase (ALK) and Epstein-Barr virus gene products in primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis.","volume":"137","author":"Herbst","year":"1997","journal-title":"Br J Dermatol."},{"key":"2020021218022884500_B253","first-page":"2697","article-title":"ALK+ lymphoma: clinico-pathological findings and outcome.","volume":"93","author":"Falini","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B254","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1182\/blood.V93.11.3913","article-title":"Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma.","volume":"93","author":"Gascoyne","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B255","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/(SICI)1097-0215(20000615)86:6<777::AID-IJC4>3.0.CO;2-D","article-title":"Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity.","volume":"86","author":"Leoncini","year":"2000","journal-title":"Int J Cancer."},{"key":"2020021218022884500_B256","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1182\/blood.V96.4.1605","article-title":"Immune response to the ALK oncogenic tyrosine kinase in patients with anaplastic large-cell lymphoma.","volume":"96","author":"Pulford","year":"2000","journal-title":"Blood."},{"key":"2020021218022884500_B257","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10428199609054798","article-title":"The clinicopathological features of anaplastic large cell lymphomas expressing p80NPM\/ALK.","volume":"23","author":"Shiota","year":"1996","journal-title":"Leuk Lymphoma."},{"key":"2020021218022884500_B258","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1182\/blood.V89.5.1483","article-title":"A new subtype of large B-cell lymphoma expressing the ALK kinase and lacking the 2;5 translocation.","volume":"89","author":"Delsol","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B259","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0002-9440(10)64545-2","article-title":"Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms.","volume":"157","author":"Ladanyi","year":"2000","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B260","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/00000478-200106000-00007","article-title":"Anaplastic lymphoma kinase expression in inflammatory pseudotumors.","volume":"25","author":"Chan","year":"2001","journal-title":"Am J Surg Pathol."},{"key":"2020021218022884500_B261","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0002-9440(10)64550-6","article-title":"TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.","volume":"157","author":"Lawrence","year":"2000","journal-title":"Am J Pathol."},{"key":"2020021218022884500_B262","first-page":"265","article-title":"The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.","volume":"12","author":"Yoneda-Kato","year":"1996","journal-title":"Oncogene."},{"key":"2020021218022884500_B263","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1182\/blood.V83.12.3629.3629","article-title":"BCR-ABL protein expression in peripheral blood cells of chronic myelogenous leukemia patients undergoing therapy.","volume":"83","author":"Guo","year":"1994","journal-title":"Blood."},{"key":"2020021218022884500_B264","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajcp\/106.4.442","article-title":"Comparison of bcr-abl protein expression and Philadelphia chromosome analyses in chronic myelogenous leukemia patients.","volume":"106","author":"Guo","year":"1996","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B265","first-page":"437","article-title":"Detection and subcellular localization of an AML1 chimeric protein in the t(8;21) positive acute myeloid leukemia.","volume":"12","author":"Sacchi","year":"1996","journal-title":"Oncogene."},{"key":"2020021218022884500_B266","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1084\/jem.169.1.87","article-title":"Antibody recognition of the tumor-specific bcr-abl joining region in chronic myeloid leukemia.","volume":"169","author":"van Denderen","year":"1989","journal-title":"J Exp Med."},{"key":"2020021218022884500_B267","first-page":"1503","article-title":"Recognition of the ALL-specific BCR-ABL junction in P190bcr-abl by monoclonal antibody ER-FP1.","volume":"8","author":"van Denderen","year":"1994","journal-title":"Leukemia."},{"key":"2020021218022884500_B268","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1182\/blood.V89.8.2909","article-title":"Monoclonal antibodies specific to the acute lymphoblastic leukemia t(1;19)-associated E2A\/pbx1 chimeric protein: characterization and diagnostic utility.","volume":"89","author":"Sang","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B269","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1182\/blood.V87.9.3587.bloodjournal8793587","article-title":"Specific human cellular immunity to bcr-abl oncogene-derived peptides.","volume":"87","author":"Bocchia","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B270","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/eji.1830270834","article-title":"Peptides derived from the whole sequence of BCR-ABL bind to several class I molecules allowing specific induction of human cytotoxic T lymphocytes.","volume":"27","author":"Buzyn","year":"1997","journal-title":"Eur J Immunol."},{"key":"2020021218022884500_B271","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1182\/blood.V88.9.3522.bloodjournal8893522","article-title":"Recognition of BCR-ABL positive leukemic blasts by human CD4+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide.","volume":"88","author":"Bosch","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B272","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1182\/blood.V88.6.2118.bloodjournal8862118","article-title":"BCR\/ABL leukemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donors.","volume":"88","author":"Pawelec","year":"1996","journal-title":"Blood."},{"key":"2020021218022884500_B273","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1182\/blood.V90.12.4938","article-title":"Naturally processed tissue- and differentiation stage-specific autologous peptides bound by HLA class I and II molecules of chronic myeloid leukemia blasts.","volume":"90","author":"Papadopoulos","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B274","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1128\/MCB.15.4.2166","article-title":"Domain organization of I \u03ba B \u03b1 and sites of interaction with NF-\u03ba B p65.","volume":"15","author":"Jaffray","year":"1995","journal-title":"Mol Cell Biol."},{"key":"2020021218022884500_B275","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0006-2952(94)90444-8","article-title":"Epidermal growth factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal growth factor receptor into the nucleus.","volume":"47","author":"Holt","year":"1994","journal-title":"Biochem Pharmacol."},{"key":"2020021218022884500_B276","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1006\/excr.1995.1122","article-title":"Ligand-induced translocation of epidermal growth factor receptor to the nucleus of NR6\/HER fibroblasts is serum dependent.","volume":"217","author":"Holt","year":"1995","journal-title":"Exp Cell Res."},{"key":"2020021218022884500_B277","first-page":"1057","article-title":"Nucleolar localization of the nucleophosmin-anaplastic lymphoma kinase is not required for malignant transformation.","volume":"58","author":"Mason","year":"1998","journal-title":"Cancer Res."},{"key":"2020021218022884500_B278","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1002\/j.1460-2075.1996.tb00875.x","article-title":"Effects on differentiation by the promyelocytic leukemia PML\/RAR\u03b1 protein depend on the fusion of the PML protein dimerization and RAR\u03b1 DNA binding domains.","volume":"15","author":"Grignani","year":"1996","journal-title":"EMBO J."},{"key":"2020021218022884500_B279","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1182\/blood.V93.11.3601","article-title":"The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas.","volume":"93","author":"Dierlamm","year":"1999","journal-title":"Blood."},{"key":"2020021218022884500_B280","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.1073\/pnas.96.12.6745","article-title":"Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays.","volume":"96","author":"Alon","year":"1999","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021218022884500_B281","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1126\/science.286.5439.531","article-title":"Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.","volume":"286","author":"Golub","year":"1999","journal-title":"Science."},{"key":"2020021218022884500_B282","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature."},{"key":"2020021218022884500_B283","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/1097-0142(19881115)62:10<2085::AID-CNCR2820621003>3.0.CO;2-R","article-title":"Expression of c-myc oncogene product and ras family oncogene products in various human malignant lymphomas defined by immunohistochemical techniques.","volume":"62","author":"Mitani","year":"1988","journal-title":"Cancer."},{"key":"2020021218022884500_B284","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(08)60476-5","article-title":"Control of c-myc regulation in normal and neoplastic cells.","volume":"56","author":"Spencer","year":"1991","journal-title":"Adv Cancer Res."},{"key":"2020021218022884500_B285","first-page":"2102","article-title":"Differential expression of c-myc protein in B and T lymphocytes.","volume":"8","author":"Lens","year":"1994","journal-title":"Leukemia."},{"key":"2020021218022884500_B286","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/10428199009042486","article-title":"Expression of c-myc p62 protein in non-Hodgkins lymphomas.","volume":"1","author":"Kittas","year":"1990","journal-title":"Leuk Lymphoma."},{"key":"2020021218022884500_B287","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0092-8674(89)90102-5","article-title":"The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization.","volume":"58","author":"van Etten","year":"1989","journal-title":"Cell."},{"key":"2020021218022884500_B288","first-page":"1459","article-title":"Normal c-abl gene protein\u2014a nuclear component.","volume":"6","author":"Dhut","year":"1991","journal-title":"Oncogene."},{"key":"2020021218022884500_B289","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1172\/JCI116786","article-title":"Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation.","volume":"92","author":"Wetzler","year":"1993","journal-title":"J Clin Invest."},{"key":"2020021218022884500_B290","first-page":"561","article-title":"Identification of two normal bcr gene products in the cytoplasm.","volume":"3","author":"Dhut","year":"1988","journal-title":"Oncogene."},{"key":"2020021218022884500_B291","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1182\/blood.V81.11.2898.2898","article-title":"BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia.","volume":"81","author":"Bedi","year":"1993","journal-title":"Blood."},{"key":"2020021218022884500_B292","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1182\/blood.V89.9.3361","article-title":"The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures.","volume":"89","author":"Butler","year":"1997","journal-title":"Blood."},{"key":"2020021218022884500_B293","first-page":"1321","article-title":"Specific immunologic recognition of the tumor-specific E2A-PBX1 fusion-point antigen in t(1;19)-positive pre-B cells.","volume":"9","author":"Berendes","year":"1995","journal-title":"Leukemia."},{"key":"2020021218022884500_B294","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1182\/blood.V86.7.2715.2715","article-title":"Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma.","volume":"86","author":"de Boer","year":"1995","journal-title":"Blood."},{"key":"2020021218022884500_B295","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/ajcp\/103.6.756","article-title":"Cyclin D1 expression in non-Hodgkin's lymphomas. Detection by immunohistochemistry.","volume":"103","author":"Zukerberg","year":"1995","journal-title":"Am J Clin Pathol."},{"key":"2020021218022884500_B296","first-page":"2035","article-title":"The human ALL-1\/MLL\/HRX antigen is predominantly localized in the nucleus of resting and proliferating peripheral blood mononuclear cells.","volume":"57","author":"Ennas","year":"1997","journal-title":"Cancer Res."},{"key":"2020021218022884500_B297","doi-asserted-by":"crossref","first-page":"6088","DOI":"10.1128\/MCB.15.11.6088","article-title":"Nuclear localization of v-Abl leads to complex formation with cyclic AMP response element (CRE)-binding protein and transactivation through CRE motifs.","volume":"15","author":"Birchenall-Roberts","year":"1995","journal-title":"Mol Cell Biol."},{"key":"2020021218022884500_B298","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1038\/sj.onc.1201367","article-title":"The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains.","volume":"15","author":"Le Brun","year":"1997","journal-title":"Oncogene."},{"key":"2020021218022884500_B299","first-page":"739","article-title":"Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements.","volume":"10","author":"Fornerod","year":"1995","journal-title":"Oncogene."}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/99\/2\/409\/1680063\/h8020200409.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/99\/2\/409\/1680063\/h8020200409.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T06:43:56Z","timestamp":1704523436000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/99\/2\/409\/53420\/Proteins-encoded-by-genes-involved-in-chromosomal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,15]]},"references-count":299,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,1,15]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.v99.2.409","relation":{},"ISSN":["1528-0020","0006-4971"],"issn-type":[{"value":"1528-0020","type":"electronic"},{"value":"0006-4971","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1,15]]}}}