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Conversely, addition of anti\u2013SDF-1 antibody or SDF-1(G2), a specific CXCR4 antagonist, to preactivated human LTCs prevented both types of primitive CFCs from re-entering a quiescent state, demonstrating that endogenous SDF-1 contributes to the control of primitive CFC proliferation in the LTC system. Interestingly, SDF-1 failed to arrest the proliferation of primitive chronic myeloid leukemia CFCs in the adherent layer of LTCs containing normal marrow stromal cells. In vivo, injection of SDF-1 arrested the cycling of normal human LTC-initiating cells as well as primitive CFCs in the marrow of nonobese diabetic\/severe combined immunodeficient mice engrafted with human cord blood cells. Conversely, injection of the antagonist, SDF-1(G2), reactivated the cycling of quiescent primitive human CFCs present in the marrow of mice engrafted with human marrow cells. These studies are the first to demonstrate a potential physiological role of SDF-1 in regulating the cell-cycle status of primitive hematopoietic cells and suggest that the deregulated cycling activity of primitive chronic myeloid leukemia (CML) cells is due to the BCR-ABL\u2013mediated disruption of a pathway shared by multiple chemokine receptors.<\/jats:p>","DOI":"10.1182\/blood.v99.3.792","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:46:40Z","timestamp":1027774000000},"page":"792-799","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":104,"title":["Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD\/SCID mice"],"prefix":"10.1182","volume":"99","author":[{"given":"Johanne","family":"Cashman","sequence":"first","affiliation":[{"name":"From the Terry Fox Laboratory, British Columbia Cancer Agency; and the Departments of Medical Genetics, Biochemistry, Medicine, and Pathology and Laboratory Medicine, and the Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Clark-Lewis","sequence":"additional","affiliation":[{"name":"From the Terry Fox Laboratory, British Columbia Cancer Agency; and the Departments of Medical Genetics, Biochemistry, Medicine, and Pathology and Laboratory Medicine, and the Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Eaves","sequence":"additional","affiliation":[{"name":"From the Terry Fox Laboratory, British Columbia Cancer Agency; and the Departments of Medical Genetics, Biochemistry, Medicine, and Pathology and Laboratory Medicine, and the Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Eaves","sequence":"additional","affiliation":[{"name":"From the Terry Fox Laboratory, British Columbia Cancer Agency; and the Departments of Medical Genetics, Biochemistry, Medicine, and Pathology and Laboratory Medicine, and the Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021215580865900_B1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood.V26.3.296.296","article-title":"The effect of differing demands for blood cell production on DNA synthesis by hemopoietic colony-forming cells of mice.","volume":"26","author":"Becker","year":"1965","journal-title":"Blood."},{"key":"2020021215580865900_B2","first-page":"683","article-title":"In vivo kinetic states of hematopoietic stem and progenitor cells as inferred from labelling with bromodeoxyuridine.","volume":"12","author":"Hodgson","year":"1984","journal-title":"Exp Hematol."},{"key":"2020021215580865900_B3","first-page":"445","article-title":"Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment.","volume":"25","author":"Bradford","year":"1997","journal-title":"Exp Hematol."},{"key":"2020021215580865900_B4","first-page":"931","article-title":"Cell culture studies in CML.","volume-title":"Bailliere's Clinical Haematology. 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