{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:36:30Z","timestamp":1791182190161,"version":"4.1.0"},"reference-count":61,"publisher":"American Society of Hematology","issue":"4","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,2,15]]},"abstract":"<jats:p>Hodgkin- and Reed-Sternberg (HRS) cells microdissected from 41 classical Hodgkin lymphomas (cHL) of 40 patients comprising 8 lymphocyte-rich (cHL-LR), 16 nodular sclerosis (cHL-NS), 15 mixed-cellularity (cHL-MC), and 2 lymphocyte-depletion (cHL-LD) subtypes were analyzed by comparative genomic hybridization for recurrently imbalanced chromosomal subregions. Chromosomal gains most frequently involved chromosome 2p (54%), 12q (37%), 17p (27%), 9p and 16p (24% each), and 17q and 20q (20% each), whereas losses primarily affected chromosome 13q (22%). Using fluorescence in situ hybridization, amplification of the REL oncogene was demonstrated within a distinct 2p15-p16 amplicon. The high frequency of 2p overrepresentations including REL, particularly in cHL-NS (88%), suggests that an alternative mechanism of constitutive activation of nuclear factor NF-\u03baB is a hallmark of HRS cells. Hierarchical cluster analysis of chromosomal imbalances revealed a closer relationship among cHL-NS than other subtypes. Furthermore, there is a tendency for different subtypes of cHL-MC tumors characterized by different ages at the time of tumor onset and gain of chromosome 17p. The imbalance pattern of cHL subtypes suggests that different molecular pathways are activated, with REL or other genes on chromosomal band 2p15-p16 playing a fundamental role in the pathogenesis of classical Hodgkin lymphoma.<\/jats:p>","DOI":"10.1182\/blood.v99.4.1381","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T08:46:40Z","timestamp":1027759600000},"page":"1381-1387","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":203,"title":["Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2"],"prefix":"10.1182","volume":"99","author":[{"given":"Stefan","family":"Joos","sequence":"first","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane K.","family":"Menz","sequence":"additional","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Wrobel","sequence":"additional","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gesk","sequence":"additional","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Ohl","sequence":"additional","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild","family":"Mechtersheimer","sequence":"additional","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Tru\u0308mper","sequence":"additional","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mo\u0308ller","sequence":"additional","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lichter","sequence":"additional","affiliation":[{"name":"From Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany; Abteilung fu\u0308r Pathologie des Universita\u0308tsklinikums Ulm, Germany; Institut fu\u0308r Humangenetik, Universita\u0308tsklinikum Kiel, Germany; Pathologisches Institut der Universita\u0308t Heidelberg, Germany; and Abteilung Innere Medizin, Klinikum der Georg-August-Universita\u0308t, Go\u0308ttingen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F. 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Tissues.","author":"Jaffe","year":"2001"},{"key":"2020021300121379400_B3","first-page":"639","article-title":"Chromosomes in Hodgkin's disease.","volume":"66","author":"Rowley","year":"1982","journal-title":"Cancer Treat Rep."},{"key":"2020021300121379400_B4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000014951","article-title":"Cytogenetics of Hodgkin's disease.","volume":"80","author":"Atkin","year":"1998","journal-title":"Cytogenet Cell Genet."},{"key":"2020021300121379400_B5","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0165-4608(88)90277-4","article-title":"Unique display of a pathologic karyotype in Hodgkin\u2032s disease by Reed-Sternberg cells.","volume":"34","author":"Teerenhovi","year":"1988","journal-title":"Cancer Genet Cytogenet."},{"key":"2020021300121379400_B6","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood.V86.4.1464.bloodjournal8641464","article-title":"Numerical chromosome aberrations are present within the CD30+ Hodgkin and Reed-Sternberg Cells in 100% of analyzed cases of Hodgkin's disease.","volume":"86","author":"Weber-Matthiesen","year":"1995","journal-title":"Blood."},{"key":"2020021300121379400_B7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/jcp.50.7.553","article-title":"Numerical chromosomal aberrations in Hodgkin's disease detected by in situ hybridization on routine paraffin sections.","volume":"50","author":"Pringle","year":"1997","journal-title":"J Clin Pathol."},{"key":"2020021300121379400_B8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1096-9896(199806)185:2<145::AID-PATH82>3.0.CO;2-F","article-title":"Chromosomal abnormalities in Hodgkin\u2032s disease are not restricted to Hodgkin\/Reed-Sternberg cells.","volume":"185","author":"Jansen","year":"1998","journal-title":"J Pathol."},{"key":"2020021300121379400_B9","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/(SICI)1097-0215(19990719)82:2<250::AID-IJC16>3.0.CO;2-L","article-title":"Genetic analysis of sorted Hodgkin and Reed-Sternberg cells using comparative genomic hybridization.","volume":"82","author":"Ohshima","year":"1999","journal-title":"Int J Cancer."},{"key":"2020021300121379400_B10","first-page":"549","article-title":"Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells.","volume":"60","author":"Joos","year":"2000","journal-title":"Cancer Res."},{"key":"2020021300121379400_B11","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1182\/blood.V97.6.1845","article-title":"Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances.","volume":"97","author":"Franke","year":"2001","journal-title":"Blood."},{"key":"2020021300121379400_B12","first-page":"4914","article-title":"Cell lines from human colon 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Comparative Genomic Hybridization.","author":"Lichter","year":"1995"},{"key":"2020021300121379400_B17","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1182\/blood.V91.11.4321","article-title":"Characteristic pattern of chromosomal gains and losses in primary large B-cell lymphomas of the gastrointestinal tract.","volume":"91","author":"Barth","year":"1998","journal-title":"Blood."},{"key":"2020021300121379400_B18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/1098-2264(200007)28:3<353::AID-GCC15>3.0.CO;2-0","article-title":"Risk of false positive results in comparative genomic hybridization.","volume":"28","author":"Barth","year":"2000","journal-title":"Genes Chromosomes Cancer."},{"key":"2020021300121379400_B19","first-page":"3803","article-title":"Mapping of chromosomal imbalances in pancreatic carcinoma by comparative genomic hybridization.","volume":"56","author":"Solinas-Toldo","year":"1996","journal-title":"Cancer Res."},{"key":"2020021300121379400_B20","first-page":"151","volume-title":"In: Wegner RD, ed. Classical and molecular cytogenetics of tumor cells.","author":"Schlegelberger","year":"1999"},{"key":"2020021300121379400_B21","volume-title":"1995: An international system for human cytogenetic nomenclature.","author":"ISCN","year":"1995"},{"key":"2020021300121379400_B22","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","article-title":"Cluster analysis and display of genome-wide expression patterns.","volume":"95","author":"Eisen","year":"1998","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021300121379400_B23","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American classification of lymphoid neoplasms: a proposal from the international lymphoma study 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chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization.","volume":"16","author":"Schu\u0308tz","year":"1996","journal-title":"Genes Chromosome Cancer."},{"key":"2020021300121379400_B27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1098-2264(199702)18:2<94::AID-GCC3>3.0.CO;2-W","article-title":"Optimizing DOP-PCR for universal amplification of small samples in comparative genomic hybridization.","volume":"18","author":"Kuukasja\u0308rvi","year":"1997","journal-title":"Genes Chromosome Cancer."},{"key":"2020021300121379400_B28","doi-asserted-by":"crossref","first-page":"14719","DOI":"10.1073\/pnas.94.26.14719","article-title":"Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression.","volume":"94","author":"Weber","year":"1997","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021300121379400_B29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0002-9440(10)65571-X","article-title":"Recurrent chromosomal imbalances detected in biopsy material from oral premalignant and malignant lesions by combined tissue microdissection, universal DNA amplification, and comparative genomic hybridization.","volume":"153","author":"Weber","year":"1998","journal-title":"Am J Pathol."},{"key":"2020021300121379400_B30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0889-8588(18)30552-5","article-title":"Chromosomal abnormalities in Hodgkin's disease.","volume":"3","author":"Thangavelu","year":"1989","journal-title":"Hematol\/Oncol Clin North Am."},{"key":"2020021300121379400_B31","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/gcc.2870050415","article-title":"Recurring chromosome abnormalities in Hodgkin's disease.","volume":"5","author":"Do\u0308hner","year":"1992","journal-title":"Genes Chromosome Cancer."},{"key":"2020021300121379400_B32","first-page":"72","article-title":"Cytogenetic findings and results of combined immunophenotyping and karyotyping in Hodgkin's disease.","volume":"8","author":"Schlegelberger","year":"1994","journal-title":"Leukemia."},{"key":"2020021300121379400_B33","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1182\/blood.V73.8.2149.2149","article-title":"Chromosomal abnormalities in Hodgkin's disease.","volume":"73","author":"Schouten","year":"1989","journal-title":"Blood."},{"key":"2020021300121379400_B34","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1182\/blood.V77.6.1298.1298","article-title":"Cytogenetic studies in untreated Hodgkin's disease.","volume":"77","author":"Tilly","year":"1991","journal-title":"Blood."},{"key":"2020021300121379400_B35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0165-4608(98)00204-0","article-title":"Chromosome aberrations in adult Hodgkin disease in a Danish population-based 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hybridization.","volume":"8","author":"Mathew","year":"1993","journal-title":"Oncogene."},{"key":"2020021300121379400_B39","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1182\/blood.V99.4.1474","article-title":"Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.","volume":"99","author":"Mart\u0131\u0301n-Subero","year":"2002","journal-title":"Blood."},{"key":"2020021300121379400_B40","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-kappa B and I kappa B proteins: new discoveries and insights.","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu Rev Immunol."},{"key":"2020021300121379400_B41","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.cb.10.110194.002201","article-title":"Structure, regulation and function of NF-kappa B.","volume":"10","author":"Siebenlist","year":"1994","journal-title":"Annu Rev Cell Biol."},{"key":"2020021300121379400_B42","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s001090050078","article-title":"The NF-kappa B\/Rel and I kappa B gene families: mediators of immune response and inflammation.","volume":"74","author":"Wulczyn","year":"1996","journal-title":"J Mol Med."},{"key":"2020021300121379400_B43","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.1038\/sj.onc.1203221","article-title":"Aberrant REL\/NFKB genes and activity in human cancer.","volume":"18","author":"Rayet","year":"1999","journal-title":"Oncogene."},{"key":"2020021300121379400_B44","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1172\/JCI119849","article-title":"Constitutive nuclear factor-\u03baB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.","volume":"100","author":"Bargou","year":"1997","journal-title":"J Clin Invest."},{"key":"2020021300121379400_B45","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/sj.onc.1201735","article-title":"Defective I\u03baB\u03b1 in Hodgkin cell lines with constitutively active NF-\u03baB.","volume":"16","author":"Wood","year":"1998","journal-title":"Oncogene."},{"key":"2020021300121379400_B46","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1084\/jem.191.2.395","article-title":"Clonal deleterious mutations in the I\u03baB\u03b1 gene in the malignant cells in Hodgkin's lymphoma.","volume":"191","author":"Jungnickel","year":"2000","journal-title":"J Exp Med."},{"key":"2020021300121379400_B47","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/sj.onc.1202351","article-title":"Molecular mechanisms of constitutive NF-\u03baB\/Rel activation in Hodgkin\/Reed-Sternberg 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\u03baB.","volume":"272","author":"Ohmori","year":"1997","journal-title":"J Biol Chem."},{"key":"2020021300121379400_B51","first-page":"311","article-title":"Transcriptional regulation of the heat shock protein genes by STAT family transcription factors.","volume":"7","author":"Stephanou","year":"1999","journal-title":"Gene Expr."},{"key":"2020021300121379400_B52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/annonc\/9.suppl_5.S31","article-title":"Workshop report on Hodgkin's disease and related diseases ('grey zone' lymphoma).","volume":"suppl 5","author":"Ru\u0308diger","year":"1998","journal-title":"Ann Oncol."},{"key":"2020021300121379400_B53","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ijc.2910300411","article-title":"Identification of Hodgkin and Sternberg-Reed cells as a unique cell type derived from a newly-detected small-cell population.","volume":"30","author":"Stein","year":"1982","journal-title":"Int J Cancer."},{"key":"2020021300121379400_B54","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1182\/blood.V69.4.1087.1087","article-title":"Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation.","volume":"69","author":"Mo\u0308ller","year":"1987","journal-title":"Blood."},{"key":"2020021300121379400_B55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/path.1711640107","article-title":"Localization of immunoglobulin light chain mRNA expression in Hodgkin's disease by in situ hybridization.","volume":"164","author":"Ruprai","year":"1991","journal-title":"J Pathol."},{"key":"2020021300121379400_B56","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1182\/blood.V87.8.3124.bloodjournal8783124","article-title":"Molecular cloning of a complex chromosomal translocation t(8;14,12)(q24.1;q32;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon.","volume":"87","author":"Zani","year":"1996","journal-title":"Blood."},{"key":"2020021300121379400_B57","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1182\/blood.V80.11.2891.2891","article-title":"Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma.","volume":"80","author":"Delabie","year":"1992","journal-title":"Blood."},{"key":"2020021300121379400_B58","first-page":"161","article-title":"Cyclins: relevance of subcellular localization in cell cycle control.","volume":"41","author":"Prosperi","year":"1997","journal-title":"Eur J Histochem."},{"key":"2020021300121379400_B59","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1038\/sj.onc.1201643","article-title":"Cloning of two candidate tumor suppressor genes within a 10-kb region on chromosome 13q14, frequently deleted in chronic lymphocytic 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