{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:55:09Z","timestamp":1791312909265,"version":"4.3.1"},"reference-count":48,"publisher":"American Society of Hematology","issue":"5","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,3,1]]},"abstract":"<jats:p>Chemokines and chemokine receptors play important roles in migration and tissue localization of various lymphocyte subsets. Here, we report the highly frequent expression of CCR4 in adult T-cell leukemia (ATL) and human T-cell leukemia virus type 1 (HTLV-1)\u2013immortalized T cells. Flow cytometric analysis revealed that ATL and HTLV-1\u2013immortalized T-cell lines consistently expressed CCR4. Inducible expression of HTLV-1 transcriptional activator tax in a human T-cell line Jurkat did not, however, up-regulate CCR4 mRNA. In vitro immortalization of peripheral blood T cells led to preferential outgrowth of CD4+ T cells expressing CCR4. We further demonstrated highly frequent expression of CCR4 in fresh ATL cells by (1) reverse transcriptase\u2013polymerase chain reaction (RT-PCR) analysis of CCR4 expression in peripheral blood mononuclear cells (PBMCs) from patients with ATL and healthy controls; (2) flow cytometric analysis of CCR4-expressing cells in PBMCs from patients with ATL and healthy controls; (3) CCR4 staining of routine blood smears from patients with ATL; and (4) an efficient migration of fresh ATL cells to the CCR4 ligands, TARC\/CCL17 and MDC\/CCL22, in chemotaxis assays. Furthermore, we detected strong signals for CCR4, TARC, and MDC in ATL skin lesions by RT-PCR. Collectively, most ATL cases have apparently derived from CD4+ T cells expressing CCR4. It is now known that circulating CCR4+ T cells are mostly polarized to Th2 and also contain essentially all skin-seeking memory T cells. Thus, HTLV-1\u2013infected CCR4+ T cells may have growth advantages by deviating host immune responses to Th2. CCR4 expression may also account for frequent infiltration of ATL into tissues such as skin and lymph nodes.<\/jats:p>","DOI":"10.1182\/blood.v99.5.1505","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:47:58Z","timestamp":1027774078000},"page":"1505-1511","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":269,"title":["Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1\u2013transformed T cells"],"prefix":"10.1182","volume":"99","author":[{"given":"Osamu","family":"Yoshie","sequence":"first","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Harasawa","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Tago","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Izawa","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Hieshima","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichi","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Matsushima","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Kanamaru","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimeru","family":"Kamihira","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Yamada","sequence":"additional","affiliation":[{"name":"From the Departments of Microbiology and Internal Medicine III, Kinki University School of Medicine, Department of Neurology, Tohoku University School of Medicine, Department of Laboratory Medicine, Nagasaki University School of Medicine, Department of Molecular Preventive Medicine, Tokyo University School of Medicine, Department of Internal Medicine, Ehime University School of Medicine, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021217412283900_B1","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1099\/0022-1317-66-8-1641","article-title":"Viral aetiology of adult T-cell leukaemia.","volume":"66","author":"Yamamoto","year":"1985","journal-title":"J Gen Virol."},{"key":"2020021217412283900_B2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.immunol.15.1.15","article-title":"Human T cell leukemia virus type I (HTLV-I) and human diseases.","volume":"15","author":"Uchiyama","year":"1997","journal-title":"Annu Rev Immunol."},{"key":"2020021217412283900_B3","first-page":"115","article-title":"Histopathological definition of the adult and calf types of bovine leukosis.","volume":"22","author":"Yamamoto","year":"1982","journal-title":"Natl Inst Anim Health Q (Tokyo)."},{"key":"2020021217412283900_B4","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1128\/JVI.64.11.5682-5687.1990","article-title":"In vivo cellular tropism of human T-cell leukemia virus type 1.","volume":"64","author":"Richardson","year":"1990","journal-title":"J Virol."},{"key":"2020021217412283900_B5","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1182\/blood.V80.12.3205.3205","article-title":"Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia\/lymphoma shows frequent p53 mutations.","volume":"80","author":"Cesarman","year":"1992","journal-title":"Blood."},{"key":"2020021217412283900_B6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0065-2776(01)78002-9","article-title":"Chemokines in immunity.","volume":"78","author":"Yoshie","year":"2001","journal-title":"Adv Immunol."},{"key":"2020021217412283900_B7","doi-asserted-by":"crossref","first-page":"13803","DOI":"10.1074\/jbc.272.21.13803","article-title":"Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7.","volume":"272","author":"Yoshida","year":"1997","journal-title":"J Biol Chem."},{"key":"2020021217412283900_B8","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1074\/jbc.273.12.7118","article-title":"Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7.","volume":"273","author":"Yoshida","year":"1998","journal-title":"J Biol Chem."},{"key":"2020021217412283900_B9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood.V95.1.30","article-title":"Increased chemokine receptor CCR7\/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells.","volume":"95","author":"Hasegawa","year":"2000","journal-title":"Blood."},{"key":"2020021217412283900_B10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/intimm\/11.1.81","article-title":"Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine.","volume":"11","author":"Imai","year":"1999","journal-title":"Int Immunol."},{"key":"2020021217412283900_B11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4049\/jimmunol.166.1.103","article-title":"C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential.","volume":"166","author":"Andrew","year":"2001","journal-title":"J Immunol."},{"key":"2020021217412283900_B12","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/23495","article-title":"The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells.","volume":"400","author":"Campbell","year":"1999","journal-title":"Nature."},{"key":"2020021217412283900_B13","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/ijc.2910610519","article-title":"Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily.","volume":"61","author":"Takagi","year":"1995","journal-title":"Int J Cancer."},{"key":"2020021217412283900_B14","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1128\/JVI.63.8.3220-3226.1989","article-title":"Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat.","volume":"63","author":"Nagata","year":"1989","journal-title":"J Virol."},{"key":"2020021217412283900_B15","doi-asserted-by":"crossref","first-page":"15036","DOI":"10.1074\/jbc.272.23.15036","article-title":"The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.","volume":"272","author":"Imai","year":"1997","journal-title":"J Biol Chem."},{"key":"2020021217412283900_B16","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1074\/jbc.273.3.1764","article-title":"Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.","volume":"273","author":"Imai","year":"1998","journal-title":"J Biol Chem."},{"key":"2020021217412283900_B17","first-page":"683","article-title":"Detection of HTLV-1 by polymerase chain reaction in situ hybridization in adult T-cell leukemia\/lymphoma.","volume":"152","author":"Setoyama","year":"1998","journal-title":"Am J Pathol."},{"key":"2020021217412283900_B18","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1172\/JCI7613","article-title":"Overproduction of Th2-specific chemokines in NC\/Nga mice exhibiting atopic dermatitis-like lesions.","volume":"104","author":"Vestergaard","year":"1999","journal-title":"J Clin Invest."},{"key":"2020021217412283900_B19","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1046\/j.1523-1747.2000.00115.x","article-title":"A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin.","volume":"115","author":"Vestergaard","year":"2000","journal-title":"J Invest Dermatol."},{"key":"2020021217412283900_B20","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0002-9440(10)64077-1","article-title":"Macrophage-derived chemokine (MDC\/CCL22) and CCR4 are involved in the formation of T lymphocyte-dendritic cell clusters in human inflamed skin and secondary lymphoid tissue.","volume":"158","author":"Katou","year":"2001","journal-title":"Am J Pathol."},{"key":"2020021217412283900_B21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/35065016","article-title":"Involvement of chemokine receptors in breast cancer metastasis.","volume":"410","author":"Muller","year":"2001","journal-title":"Nature."},{"key":"2020021217412283900_B22","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1182\/blood.V95.2.627","article-title":"The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia.","volume":"95","author":"Jones","year":"2000","journal-title":"Blood."},{"key":"2020021217412283900_B23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI7335","article-title":"The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis.","volume":"104","author":"Trentin","year":"1999","journal-title":"J Clin Invest."},{"key":"2020021217412283900_B24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/35876","article-title":"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.","volume":"391","author":"Gunn","year":"1998","journal-title":"Nature."},{"key":"2020021217412283900_B25","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.187.4.655","article-title":"B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1\/CXCR5.","volume":"187","author":"Legler","year":"1998","journal-title":"J Exp Med."},{"key":"2020021217412283900_B26","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.191.8.1303","article-title":"Developmental switches in chemokine response profiles during B cell differentiation and maturation.","volume":"191","author":"Bowman","year":"2000","journal-title":"J Exp Med."},{"key":"2020021217412283900_B27","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1084\/jem.187.12.2009","article-title":"Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.","volume":"187","author":"Cole","year":"1998","journal-title":"J Exp Med."},{"key":"2020021217412283900_B28","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1084\/jem.184.3.963","article-title":"Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.","volume":"184","author":"Loetscher","year":"1996","journal-title":"J Exp Med."},{"key":"2020021217412283900_B29","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1172\/JCI1422","article-title":"The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.","volume":"101","author":"Qin","year":"1998","journal-title":"J Clin Invest."},{"key":"2020021217412283900_B30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1182\/blood.V96.2.685","article-title":"Expression pattern of T-cell-associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma.","volume":"96","author":"Jones","year":"2000","journal-title":"Blood."},{"key":"2020021217412283900_B31","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1189\/jlb.68.4.568","article-title":"Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells.","volume":"68","author":"Yamamoto","year":"2000","journal-title":"J Leukoc Biol."},{"key":"2020021217412283900_B32","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1182\/blood.V82.5.1590.1590","article-title":"E-selectin and vascular cell adhesion molecule-1 mediate adult T-cell leukemia cell adhesion to endothelial cells.","volume":"82","author":"Ishikawa","year":"1993","journal-title":"Blood."},{"key":"2020021217412283900_B33","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1084\/jem.184.5.1987","article-title":"Heparan sulfate proteoglycan on leukemic cells is primarily involved in integrin triggering and its mediated adhesion to endothelial cells.","volume":"184","author":"Tanaka","year":"1996","journal-title":"J Exp Med."},{"key":"2020021217412283900_B34","doi-asserted-by":"crossref","first-page":"8508","DOI":"10.1128\/JVI.70.12.8508-8517.1996","article-title":"Differential transactivation of the intercellular adhesion molecule 1 gene promoter by Tax1 and Tax2 of human T-cell leukemia viruses.","volume":"70","author":"Tanaka","year":"1996","journal-title":"J Virol."},{"key":"2020021217412283900_B35","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1182\/blood.V89.8.2951","article-title":"OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration.","volume":"89","author":"Imura","year":"1997","journal-title":"Blood."},{"key":"2020021217412283900_B36","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1128\/MCB.11.3.1313","article-title":"Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax.","volume":"11","author":"Miura","year":"1991","journal-title":"Mol Cell Biol."},{"key":"2020021217412283900_B37","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ijc.2910520316","article-title":"Strong induction of ICAM-1 in human T cells transformed by human T-cell-leukemia virus type 1 and depression of ICAM-1 or LFA-1 in adult T-cell-leukemia-derived cell lines.","volume":"52","author":"Fukudome","year":"1992","journal-title":"Int J Cancer."},{"key":"2020021217412283900_B38","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/ijc.2910550520","article-title":"Enhanced expression of LFA-3 on human T-cell lines and leukemic cells carrying human T-cell-leukemia virus type 1.","volume":"55","author":"Imai","year":"1993","journal-title":"Int J Cancer."},{"key":"2020021217412283900_B39","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/(SICI)1097-0215(19960328)66:1<124::AID-IJC21>3.0.CO;2-C","article-title":"Constitutive expression of various chemokine genes in human T-cell lines infected with human T-cell leukemia virus type 1: role of the viral transactivator Tax.","volume":"66","author":"Baba","year":"1996","journal-title":"Int J Cancer."},{"key":"2020021217412283900_B40","doi-asserted-by":"crossref","first-page":"8522","DOI":"10.1128\/JVI.71.11.8522-8530.1997","article-title":"Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.","volume":"71","author":"Valentin","year":"1997","journal-title":"J Virol."},{"key":"2020021217412283900_B41","first-page":"639","article-title":"Immune suppression in healthy carriers of adult T-cell leukemia retrovirus (HTLV-I): impairment of T-cell control of Epstein-Barr virus-infected B-cells.","volume":"78","author":"Katsuki","year":"1987","journal-title":"Jpn J Cancer Res."},{"key":"2020021217412283900_B42","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ijc.2910420605","article-title":"Suppression of tuberculin skin reaction in healthy HTLV-I carriers from Japan.","volume":"42","author":"Tachibana","year":"1988","journal-title":"Int J Cancer."},{"key":"2020021217412283900_B43","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/ijc.2910560307","article-title":"Decreased reactivity to PPD among HTLV-I carriers in relation to virus and hematologic status.","volume":"56","author":"Welles","year":"1994","journal-title":"Int J Cancer."},{"key":"2020021217412283900_B44","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1348-0421.1996.tb01082.x","article-title":"In vitro effects of immunosuppressive agents on cytokine production by HTLV-I-infected T cell clones derived from the ocular fluid of patients with HTLV-I uveitis.","volume":"40","author":"Sagawa","year":"1996","journal-title":"Microbiol Immunol."},{"key":"2020021217412283900_B45","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/10428199609093442","article-title":"Features of the cytokines secreted by adult T cell leukemia (ATL) cells.","volume":"21","author":"Yamada","year":"1996","journal-title":"Leuk Lymph."},{"key":"2020021217412283900_B46","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.4049\/jimmunol.165.4.2205","article-title":"Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells.","volume":"165","author":"Sekiya","year":"2000","journal-title":"J Immunol."},{"key":"2020021217412283900_B47","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1002\/(SICI)1521-4141(199906)29:06<1925::AID-IMMU1925>3.0.CO;2-U","article-title":"Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.","volume":"29","author":"Kanazawa","year":"1999","journal-title":"Eur J Immunol."},{"key":"2020021217412283900_B48","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/1523-1747.ep12364814","article-title":"Skin-selective lymphocyte homing mechanisms in the pathogenesis of leukemic cutaneous T-cell lymphoma.","volume":"101","author":"Heald","year":"1993","journal-title":"J Invest Dermatol."}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/99\/5\/1505\/1681090\/h8050201505.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/99\/5\/1505\/1681090\/h8050201505.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T06:43:44Z","timestamp":1704523424000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/99\/5\/1505\/106925\/Frequent-expression-of-CCR4-in-adult-Tcell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,1]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,3,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.v99.5.1505","relation":{},"ISSN":["1528-0020","0006-4971"],"issn-type":[{"value":"1528-0020","type":"electronic"},{"value":"0006-4971","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3,1]]}}}