{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:09:14Z","timestamp":1791425354630,"version":"4.3.3"},"reference-count":19,"publisher":"American Society of Hematology","issue":"6","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies on the immunoglobulin variable heavy chain (IgVH) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated VH genes. We have analyzed the VH gene mutation status and VH gene usage in 119 B-CLL cases and correlated them to overall survival. A novel finding was the preferential use of the VH3-21 gene in mutated cases, whereas biased VH1-69 gene usage was found in unmutated cases as previously reported. Interestingly, the subset of mutated cases using the VH3-21 gene displayed distinctive genotypic\/phenotypic characteristics with shorter average length of the complementarity determining region 3 and clonal expression of \u03bb light chains. In addition, this mutated subset showed significantly shorter survival than other mutated cases and a similar clinical course to unmutated cases. We therefore suggest that B-CLL cases with mutated VH3-21 genes may constitute an additional entity of B-CLL.<\/jats:p>","DOI":"10.1182\/blood.v99.6.2262","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T21:48:18Z","timestamp":1033508898000},"page":"2262-2264","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":252,"title":["Somatically mutated Ig VH3-21 genes characterize a new subset of chronic lymphocytic leukemia"],"prefix":"10.1182","volume":"99","author":[{"given":"Gerard","family":"Tobin","sequence":"first","affiliation":[{"name":"From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Thunberg","sequence":"additional","affiliation":[{"name":"From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Tho\u0308rn","sequence":"additional","affiliation":[{"name":"From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"So\u0308derberg","sequence":"additional","affiliation":[{"name":"From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Hultdin","sequence":"additional","affiliation":[{"name":"From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Botling","sequence":"additional","affiliation":[{"name":"From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Enblad","sequence":"additional","affiliation":[{"name":"From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Ume\u00e5 University, Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sa\u0308llstro\u0308m","sequence":"additional","affiliation":[{"name":"From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Ume\u00e5 University, Ume\u00e5, 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