{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:12:56Z","timestamp":1791295976338,"version":"4.1.0"},"reference-count":58,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p>Impaired polymorphonuclear neutrophil (PMN) functions during sickle cell anemia (SCA) may have a pathogenic role in the onset of vasoocclusive events. We used flow cytometry to study, in whole blood, the adhesion molecule expression and respiratory burst of PMNs from children with SCA. Three different clinical groups were studied: (1) patients with no history of vasoocclusive events (n\u2009=\u200915); (2) patients with a history of vasoocclusive events (n\u2009=\u200917); and (3) patients receiving hydroxyurea therapy for severe vasoocclusive events (n\u2009=\u20099). Unstimulated PMNs showed decreased L selectin expression and increased H2O2 production whatever the severity of the disease, reflecting PMN activation. This could contribute to endothelial activation reflected by abnormal plasma levels of soluble adhesion molecules (soluble intercellular adhesion molecule-1, sE selectin, and sL selectin). After stimulation with bacterial N-formyl peptides (N-formyl-methionyl-leucyl-phenylalanine [fMLP]), PMNs from untreated patients with a history of vasoocclusive events showed dysregulated L selectin shedding and increased H2O2 production. Furthermore, in these patients, tumor necrosis factor priming followed by fMLP stimulation induced an H2O2 production significantly higher than in the other patient groups and controls. These impairments could immobilize PMNs on the endothelium, thereby inducing reduced blood flow and fostering microvascular occlusion and vascular damage. In contrast, children treated with hydroxyurea showed near-normal basal and poststimulation H2O2 production as well as normal L selectin shedding after stimulation but no change in plasma levels of soluble adhesion molecules. To our knowledge, this is the first report showing major qualitative changes of PMN abnormalities upon hydroxyurea treatment in SCA patients. This strongly suggests that PMNs are a primary target of this drug.<\/jats:p>","DOI":"10.1182\/blood.v99.7.2297","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T14:33:52Z","timestamp":1034346832000},"page":"2297-2303","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":90,"title":["Hydroxyurea corrects the dysregulated L-selectin expression and increased H2O2 production of polymorphonuclear neutrophils from patients with sickle cell anemia"],"prefix":"10.1182","volume":"99","author":[{"given":"Malika","family":"Benkerrou","sequence":"first","affiliation":[{"name":"From INSERM U479 and Service d'Immunologie et d'He\u0301matologie, CHU X Bichat; and Centre de la Dre\u0301panocytose and INSERM U458, Ho\u0302pital Robert-Debre\u0301; both of Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Delarche","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d'Immunologie et d'He\u0301matologie, CHU X Bichat; and Centre de la Dre\u0301panocytose and INSERM U458, Ho\u0302pital Robert-Debre\u0301; both of Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Brahimi","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d'Immunologie et d'He\u0301matologie, CHU X Bichat; and Centre de la Dre\u0301panocytose and INSERM U458, Ho\u0302pital Robert-Debre\u0301; both of Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miche\u0300le","family":"Fay","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d'Immunologie et d'He\u0301matologie, CHU X Bichat; and Centre de la Dre\u0301panocytose and INSERM U458, Ho\u0302pital Robert-Debre\u0301; both of Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Vilmer","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d'Immunologie et d'He\u0301matologie, CHU X Bichat; and Centre de la Dre\u0301panocytose and INSERM U458, Ho\u0302pital Robert-Debre\u0301; both of Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Elion","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d'Immunologie et d'He\u0301matologie, CHU X Bichat; and Centre de la Dre\u0301panocytose and INSERM U458, Ho\u0302pital Robert-Debre\u0301; both of Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Gougerot-Pocidalo","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d'Immunologie et d'He\u0301matologie, CHU X Bichat; and Centre de la Dre\u0301panocytose and INSERM U458, Ho\u0302pital Robert-Debre\u0301; both of Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Elbim","sequence":"additional","affiliation":[{"name":"From INSERM U479 and Service d'Immunologie et d'He\u0301matologie, CHU X Bichat; and Centre de la Dre\u0301panocytose and INSERM U458, Ho\u0302pital Robert-Debre\u0301; both of Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021221454749600_B1","volume-title":"Sickle Cell Disease.","author":"Serjeant","year":"1992"},{"key":"2020021221454749600_B2","volume-title":"Sickle Cell Disease: Basic Principles and Clinical Practice.","author":"Embury","year":"1994"},{"key":"2020021221454749600_B3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJM199107043250103","article-title":"Pain in sickle cell disease\u2014rates and risk factors.","volume":"325","author":"Platt","year":"1991","journal-title":"N Engl J Med."},{"key":"2020021221454749600_B4","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1172\/JCI119442","article-title":"Adhesive interactions of sickle erythrocytes with endothelium.","volume":"99","author":"Hebbel","year":"1997","journal-title":"J Clin Invest."},{"key":"2020021221454749600_B5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1172\/JCI9225","article-title":"Hypoxia\/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice.","volume":"106","author":"Kaul","year":"2000","journal-title":"J Clin Invest."},{"key":"2020021221454749600_B6","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJM199505183322001","article-title":"Effect of hydroxyurea on frequency of painful crises in sickle cell anemia.","volume":"332","author":"Charache","year":"1995","journal-title":"N Engl J Med."},{"key":"2020021221454749600_B7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00062752-199903000-00010","article-title":"Long-term hydroxyurea treatment in young sickle cell patients.","volume":"6","author":"Maier-Redelsperger","year":"1999","journal-title":"Curr Opin Hematol."},{"key":"2020021221454749600_B8","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1182\/blood.V80.10.2634.2634","article-title":"Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells.","volume":"80","author":"Sugihara","year":"1992","journal-title":"Blood."},{"key":"2020021221454749600_B9","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1182\/blood.V96.7.2451","article-title":"Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion.","volume":"96","author":"Belcher","year":"2000","journal-title":"Blood."},{"key":"2020021221454749600_B10","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease: life expectancy and risk factors for early death.","volume":"330","author":"Platt","year":"1994","journal-title":"N Engl J Med."},{"key":"2020021221454749600_B11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1056\/NEJM200001133420203","article-title":"Prediction of adverse outcomes in children with sickle cell disease.","volume":"342","author":"Miller","year":"2000","journal-title":"N Engl J Med."},{"key":"2020021221454749600_B12","first-page":"42","article-title":"Hydroxyurea therapy for diverse pediatric populations with sickle cell disease.","volume":"34","author":"Rogers","year":"1997","journal-title":"Semin Hematol."},{"key":"2020021221454749600_B13","first-page":"15","article-title":"Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults.","volume":"34","author":"Charache","year":"1997","journal-title":"Semin Hematol."},{"key":"2020021221454749600_B14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.me.38.020187.001135","article-title":"Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150\u201395 glycoproteins.","volume":"38","author":"Anderson","year":"1987","journal-title":"Annu Rev Med."},{"key":"2020021221454749600_B15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1172\/JCI116210","article-title":"Selectins.","volume":"91","author":"Bevilacqua","year":"1993","journal-title":"J Clin Invest."},{"key":"2020021221454749600_B16","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/blood.V64.5.959.959","article-title":"Oxidants from phagocytes: agents of defense and destruction.","volume":"64","author":"Babior","year":"1984","journal-title":"Blood."},{"key":"2020021221454749600_B17","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1182\/blood.V65.3.513.513","article-title":"Leukocyte-endothelial interactions.","volume":"65","author":"Harlan","year":"1985","journal-title":"Blood."},{"key":"2020021221454749600_B18","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1126\/science.3810154","article-title":"Oxygen free radicals linked to many diseases.","volume":"235","author":"Marx","year":"1987","journal-title":"Science."},{"key":"2020021221454749600_B19","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1182\/blood.V82.6.1891.1891","article-title":"\u03b14\u03b21-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium.","volume":"82","author":"Swerlick","year":"1993","journal-title":"Blood."},{"key":"2020021221454749600_B20","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1182\/blood.V95.10.3232","article-title":"Perfusion with sickle erythrocytes up-regulates ICAM-1 and VCAM-1 gene expression in cultured human endothelial cells.","volume":"95","author":"Shiu","year":"2000","journal-title":"Blood."},{"key":"2020021221454749600_B21","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1182\/blood.V87.10.4440.bloodjournal87104440","article-title":"Sickle erythrocytes adhere to polymorphonuclear neutrophils and activate the neutrophil respiratory burst.","volume":"87","author":"Hofstra","year":"1996","journal-title":"Blood."},{"key":"2020021221454749600_B22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2141.1991.tb04461.x","article-title":"Abnormal neutrophil adhesion in sickle cell anaemia and crisis: relationship to blood 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syndrome.","volume":"344","author":"Donnelly","year":"1994","journal-title":"Lancet."},{"key":"2020021221454749600_B31","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.4049\/jimmunol.130.4.1910","article-title":"Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.","volume":"130","author":"Bass","year":"1983","journal-title":"J Immunol."},{"key":"2020021221454749600_B32","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1182\/blood.V82.2.633.633","article-title":"Priming of polymorphonuclear neutrophils by tumor necrosis factor \u03b1 in whole blood: identification of two polymorphonuclear neutrophil subpopulations in response to formyl-peptides.","volume":"82","author":"Elbim","year":"1993","journal-title":"Blood."},{"key":"2020021221454749600_B33","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V84.8.2759.2759","article-title":"Polymorphonuclear neutrophils from human 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corticosteroids.","volume":"32","author":"Taieb","year":"2000","journal-title":"J Hepatol."},{"key":"2020021221454749600_B39","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.4049\/jimmunol.164.8.4120","article-title":"Sulfhydryl regulation of L-selectin shedding: phenylarsine oxide promotes activation-independent L-selectin shedding from leukocytes.","volume":"164","author":"Bennett","year":"2000","journal-title":"J Immunol."},{"key":"2020021221454749600_B40","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.193.7.863","article-title":"L-selectin shedding regulates leukocyte recruitment.","volume":"193","author":"Hafezi-Moghadam","year":"2001","journal-title":"J Exp Med."},{"key":"2020021221454749600_B41","doi-asserted-by":"crossref","first-page":"18485","DOI":"10.1016\/S0021-9258(17)32335-9","article-title":"Potentiation of the oxidative burst of human neutrophils. A signaling role for L-selectin.","volume":"269","author":"Waddell","year":"1994","journal-title":"J Biol Chem."},{"key":"2020021221454749600_B42","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-0609.1998.tb01060.x","article-title":"Acute phase proteins and interleukins in steady state sickle cell disease.","volume":"61","author":"Bourantas","year":"1998","journal-title":"Eur J Haematol."},{"key":"2020021221454749600_B43","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1182\/blood.V92.7.2551","article-title":"Plasma endothelin-1, cytokine, and prostaglandin E2 levels in sickle cell disease and acute vaso-occlusive sickle crisis.","volume":"92","author":"Graido-Gonzalez","year":"1998","journal-title":"Blood."},{"key":"2020021221454749600_B44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1096-8652(200006)64:2<91::AID-AJH3>3.0.CO;2-P","article-title":"Tumor necrosis factor-alpha is undetectable in the plasma of SS patients with elevated HbF.","volume":"64","author":"Raghupathy","year":"2000","journal-title":"Am J Hematol."},{"key":"2020021221454749600_B45","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0022-2143(97)90095-0","article-title":"Platelet-activating factor in plasma of patients with sickle cell disease in steady state.","volume":"130","author":"Oh","year":"1997","journal-title":"J Lab Clin Med."},{"key":"2020021221454749600_B46","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1172\/JCI116706","article-title":"Activation of the alternative complement pathway by exposure of phosphatidylserine on erythrocytes from sickle cell disease patients.","volume":"92","author":"Wang","year":"1993","journal-title":"J Clin Invest."},{"key":"2020021221454749600_B47","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1006\/clin.1995.1131","article-title":"Complement activation during painful crisis in sickle cell anemia.","volume":"76","author":"Mold","year":"1995","journal-title":"Clin Immunol Immunopathol."},{"key":"2020021221454749600_B48","first-page":"409a","article-title":"Elevated levels of circulating molecules of potential endothelial origin in sickle cell disease [abstract].","volume":"81","author":"Blei","year":"1994","journal-title":"Blood."},{"key":"2020021221454749600_B49","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1182\/blood.V84.11.3766.bloodjournal84113766","article-title":"Localization of ligands for L-selectin in mouse peripheral lymph node high endothelial cells by colloidal gold conjugates.","volume":"84","author":"Kikuta","year":"1994","journal-title":"Blood."},{"key":"2020021221454749600_B50","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00024382-200115040-00002","article-title":"The effect of trauma on neutrophil L-selectin expression and sL-selectin serum levels.","volume":"15","author":"Seekamp","year":"2001","journal-title":"Shock."},{"key":"2020021221454749600_B51","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1056\/NEJM199711273372203","article-title":"Circulating activated endothelial cells in sickle cell anemia.","volume":"337","author":"Solovey","year":"1997","journal-title":"N Engl J Med."},{"key":"2020021221454749600_B52","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/clin.1996.0163","article-title":"Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis.","volume":"81","author":"Duits","year":"1996","journal-title":"Clin Immunol Immunopathol."},{"key":"2020021221454749600_B53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000040859","article-title":"Cytokines and soluble adhesion molecules in sickle cell anemia patients during hydroxyurea therapy.","volume":"100","author":"Saleh","year":"1998","journal-title":"Acta Haematol."},{"key":"2020021221454749600_B54","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1182\/blood.V85.1.268.bloodjournal851268","article-title":"Sickle reticulocytes adhere to VCAM-1.","volume":"85","author":"Gee","year":"1995","journal-title":"Blood."},{"key":"2020021221454749600_B55","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1182\/blood.V79.10.2555.2555","article-title":"Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia.","volume":"79","author":"Charache","year":"1992","journal-title":"Blood."},{"key":"2020021221454749600_B56","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1182\/blood.V91.12.4472","article-title":"Fetal hemoglobin and F-cell responses to long-term hydroxyurea treatment in young sickle cell patients. 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