{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:57:06Z","timestamp":1789732626662,"version":"4.0.1"},"reference-count":10,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p>The protein Z\u2013protein Z-dependent inhibitor complex is a factor Xa inhibitor. Protein Z deficiencies have recently been described in patients with ischemic stroke. As placenta infarction leads to poor pregnancy outcome, we studied protein Z plasma concentrations in nonthrombotic, nonthrombophilic consecutive patients with unexplained pregnancy wastage. A significant amount of protein Z deficiencies was only found in the early fetal loss group (&amp;lt;\u20091 mg\/L; 44 of 200,P\u2009&amp;lt;\u200910\u22124) and mainly in the case of fetal demise between the beginning of the 10th and the end of the 15th week of gestation (odds ratio, 6.7 [3.1-14.8],P\u2009&amp;lt;\u200910\u22123). These deficiencies were not due to partial vitamin K1 deficiency, and at least some of them were constitutional ones. In women, protein Z deficiency may induce an enhanced risk of severe placental insufficiency soon after the connection of maternal and fetal circulations.<\/jats:p>","DOI":"10.1182\/blood.v99.7.2606","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T14:33:52Z","timestamp":1034346832000},"page":"2606-2608","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":82,"title":["High frequency of protein Z deficiency in patients with unexplained early fetal loss"],"prefix":"10.1182","volume":"99","author":[{"given":"Jean-Christophe","family":"Gris","sequence":"first","affiliation":[{"name":"From the Laboratoires d'He\u0301matologie, U.F.R. des sciences pharmaceutiques et biologiques de Montpellier, Centres Hospitaliers Universitaires de N\u0131\u0302mes et de Rouen; De\u0301partement de Gyne\u0301cologie et Obste\u0301trique, Ho\u0302pital Caremeau, N\u0131\u0302mes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Que\u0301re\u0301","sequence":"additional","affiliation":[{"name":"From the Laboratoires d'He\u0301matologie, U.F.R. des sciences pharmaceutiques et biologiques de Montpellier, Centres Hospitaliers Universitaires de N\u0131\u0302mes et de Rouen; De\u0301partement de Gyne\u0301cologie et Obste\u0301trique, Ho\u0302pital Caremeau, N\u0131\u0302mes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve\u0301","family":"Dechaud","sequence":"additional","affiliation":[{"name":"From the Laboratoires d'He\u0301matologie, U.F.R. des sciences pharmaceutiques et biologiques de Montpellier, Centres Hospitaliers Universitaires de N\u0131\u0302mes et de Rouen; De\u0301partement de Gyne\u0301cologie et Obste\u0301trique, Ho\u0302pital Caremeau, N\u0131\u0302mes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Mercier","sequence":"additional","affiliation":[{"name":"From the Laboratoires d'He\u0301matologie, U.F.R. des sciences pharmaceutiques et biologiques de Montpellier, Centres Hospitaliers Universitaires de N\u0131\u0302mes et de Rouen; De\u0301partement de Gyne\u0301cologie et Obste\u0301trique, Ho\u0302pital Caremeau, N\u0131\u0302mes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Pinc\u0327on","sequence":"additional","affiliation":[{"name":"From the Laboratoires d'He\u0301matologie, U.F.R. des sciences pharmaceutiques et biologiques de Montpellier, Centres Hospitaliers Universitaires de N\u0131\u0302mes et de Rouen; De\u0301partement de Gyne\u0301cologie et Obste\u0301trique, Ho\u0302pital Caremeau, N\u0131\u0302mes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Me\u0301de\u0301ric","family":"Hoffet","sequence":"additional","affiliation":[{"name":"From the Laboratoires d'He\u0301matologie, U.F.R. des sciences pharmaceutiques et biologiques de Montpellier, Centres Hospitaliers Universitaires de N\u0131\u0302mes et de Rouen; De\u0301partement de Gyne\u0301cologie et Obste\u0301trique, Ho\u0302pital Caremeau, N\u0131\u0302mes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Vasse","sequence":"additional","affiliation":[{"name":"From the Laboratoires d'He\u0301matologie, U.F.R. des sciences pharmaceutiques et biologiques de Montpellier, Centres Hospitaliers Universitaires de N\u0131\u0302mes et de Rouen; De\u0301partement de Gyne\u0301cologie et Obste\u0301trique, Ho\u0302pital Caremeau, N\u0131\u0302mes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Mare\u0300s","sequence":"additional","affiliation":[{"name":"From the Laboratoires d'He\u0301matologie, U.F.R. des sciences pharmaceutiques et biologiques de Montpellier, Centres Hospitaliers Universitaires de N\u0131\u0302mes et de Rouen; De\u0301partement de Gyne\u0301cologie et Obste\u0301trique, Ho\u0302pital Caremeau, N\u0131\u0302mes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021222513684100_B1","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1182\/blood.V96.9.3049","article-title":"Characterization of protein Z-dependent protease inhibitor.","volume":"96","author":"Han","year":"2000","journal-title":"Blood."},{"key":"2020021222513684100_B2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1055\/s-0037-1616195","article-title":"Protein Z-dependent regulation of coagulation.","volume":"86","author":"Broze","year":"2001","journal-title":"Thromb Haemost."},{"key":"2020021222513684100_B3","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1073\/pnas.120081897","article-title":"Prothrombotic phenotype of protein Z deficiency.","volume":"97","author":"Yin","year":"2000","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2020021222513684100_B4","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(00)04218-5","article-title":"Frequency of protein Z deficiency in patients with ischaemic stroke.","volume":"357","author":"Vasse","year":"2001","journal-title":"Lancet."},{"key":"2020021222513684100_B5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1469-0705.1999.14030175.x","article-title":"Yolk sac and umbilicoplacental hemodynamics during early human embryonic development.","volume":"14","author":"Makikallio","year":"1999","journal-title":"Ultrasound Obstet Gynecol."},{"key":"2020021222513684100_B6","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1055\/s-0038-1656119","article-title":"Prospective evaluation of the prevalence of haemostasis abnormalities in unexplained primary early recurrent miscarriages\u2014the N\u0131\u0302mes obstetricians and haematologists study (NOHA).","volume":"77","author":"Gris","year":"1997","journal-title":"Thromb Haemost."},{"key":"2020021222513684100_B7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1055\/s-0037-1614594","article-title":"Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent\u2014the N\u0131\u0302mes Obstetricians and Haematologists Study5 (NOHA5).","volume":"81","author":"Gris","year":"1999","journal-title":"Thromb Haemost."},{"key":"2020021222513684100_B8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1055\/s-0037-1614001","article-title":"Antiphospholipid and antiprotein syndromes in non-thrombotic, non-autoimmune women with unexplained recurrent primary early foetal loss\u2014the N\u0131\u0302mes Obstetricians and Haematologists Study4 (NOHA4).","volume":"84","author":"Gris","year":"2000","journal-title":"Thromb Haemost."},{"key":"2020021222513684100_B9","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0015-0282(01)01678-8","article-title":"Vitamin supplementation and pregnancy outcome in women with recurrent early pregnancy loss and hyperhomocysteinemia.","volume":"75","author":"Que\u0301re\u0301","year":"2001","journal-title":"Fertil Steril."},{"key":"2020021222513684100_B10","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1182\/blood.V69.6.1580.1580","article-title":"Human plasma protein Z antigen: range in normal subjects and effect of warfarin therapy.","volume":"69","author":"Miletich","year":"1987","journal-title":"Blood."}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/99\/7\/2606\/1681744\/2606.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/99\/7\/2606\/1681744\/2606.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T22:51:43Z","timestamp":1581547903000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/99\/7\/2606\/106697\/High-frequency-of-protein-Z-deficiency-in-patients"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,4,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.v99.7.2606","relation":{},"ISSN":["1528-0020","0006-4971"],"issn-type":[{"value":"1528-0020","type":"electronic"},{"value":"0006-4971","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4,1]]}}}