{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:46:33Z","timestamp":1791179193783,"version":"4.1.0"},"reference-count":14,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p>CD40 ligand (CD40L) is expressed on activated CD4+ T lymphocytes and at the activated platelet surface. A circulating soluble form of CD40L (sCD40L) is generated by the way of a proteolytic cleavage. We measured sCD40L in the plasma of either healthy subjects; patients with inflammatory disorders and low, normal, or high platelet count (reactive thrombocytosis); or patients with essential thrombocythemia (ET). A tight correlation was found between the platelet count and plasma sCD40L. ET patients had the highest levels of sCD40L. Platelet-associated CD40L was increased in ET and reactive thrombocytosis, conditions associated with increased platelet regeneration. Platelet-associated CD40L was released upon platelet activation. In conclusion, platelets appear as a reservoir of CD40L that may be a major contributor to circulating sCD40L. Platelet-associated CD40L may be a potential marker of platelet regeneration.<\/jats:p>","DOI":"10.1182\/blood.v99.7.2612","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T14:33:52Z","timestamp":1034346832000},"page":"2612-2614","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":117,"title":["Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis"],"prefix":"10.1182","volume":"99","author":[{"given":"Jean-Franc\u0327ois","family":"Viallard","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Solanilla","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Gauthier","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce\u0301cile","family":"Contin","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"De\u0301chanet","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Grosset","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Franc\u0327ois","family":"Moreau","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Praloran","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paquita","family":"Nurden","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Pellegrin","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; UMR 5540 and UMR 5533 CNRS, Universite\u0301 de Bordeaux 2, Bordeaux and Pessac, respectively, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.","family":"Nurden","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine and the Department of Hematology, Ho\u0302pital Haut-Le\u0301ve\u0302que, Pessac, France; 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