{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:44:20Z","timestamp":1792709060571,"version":"4.5.0"},"reference-count":73,"publisher":"American Society of Hematology","issue":"8","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cb2 is a novel protooncogene encoding the peripheral cannabinoid receptor. Previous studies demonstrated that 2 distinct noncoding first exons exist: exon-1A and exon-1B, which both splice to protein-coding exon-2. We demonstrate that in retrovirally induced murine myeloid leukemia cells with proviral insertion inCb2, exon-1B\/exon-2 Cb2 messenger RNA levels have been increased, resulting in high receptor numbers. In myeloid leukemia cells without virus insertion in this locus, low levels of only exon-1A\/exon-2 Cb2 transcripts were present and receptors could not be detected. To elucidate the function of Cb2 in myeloid leukemia cells, a set of in vitro experiments was carried out using 32D\/G-CSF-R (granulocyte colony-stimulating factor receptor) cells transfected with exon-1B\/exon-2 Cb2 complementary DNA and a myeloid cell line carrying a virus insertion in Cb2(ie, NFS 78). We demonstrate that a major function of the Cb2 receptor is stimulation of migration as determined in a transwell assay. Exposure of Cb2-expressing cells to different cannabinoids showed that the true ligand for Cb2 is 2-arachidonoylglycerol (2-AG), which may act as chemoatractant and as a chemokinetic agent. Furthermore, we observed a significant synergistic activity between 2-AG and interleukin-3 or G-CSF, suggesting cross-talk between the different receptor systems. Radioactive-ligand binding studies revealed significant numbers of Cb2 receptors in normal spleen. Transwell experiments carried out with normal mouse spleen cells showed 2-AG\u2013induced migration of B220-, CD19-, immunoglobulin M\u2013, and immunoglobulin D\u2013expressing B lymphocytes. Our study demonstrates that a major function of Cb2 receptor expressed on myeloid leukemia cells or normal splenocytes is stimulation of migration.<\/jats:p>","DOI":"10.1182\/blood.v99.8.2786","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:33:52Z","timestamp":1034361232000},"page":"2786-2793","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":139,"title":["Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol"],"prefix":"10.1182","volume":"99","author":[{"given":"Meritxell","family":"Alberich Jorda\u0300","sequence":"first","affiliation":[{"name":"From the Institute for Hematology, Erasmus University Rotterdam, The Netherlands; and Department of Experimental Medicine and Biochemical Sciences, University of Rome \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Verbakel","sequence":"additional","affiliation":[{"name":"From the Institute for Hematology, Erasmus University Rotterdam, The Netherlands; and Department of Experimental Medicine and Biochemical Sciences, University of Rome \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J. M.","family":"Valk","sequence":"additional","affiliation":[{"name":"From the Institute for Hematology, Erasmus University Rotterdam, The Netherlands; and Department of Experimental Medicine and Biochemical Sciences, University of Rome \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda V.","family":"Vankan-Berkhoudt","sequence":"additional","affiliation":[{"name":"From the Institute for Hematology, Erasmus University Rotterdam, The Netherlands; and Department of Experimental Medicine and Biochemical Sciences, University of Rome \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Maccarrone","sequence":"additional","affiliation":[{"name":"From the Institute for Hematology, Erasmus University Rotterdam, The Netherlands; and Department of Experimental Medicine and Biochemical Sciences, University of Rome \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allessandro","family":"Finazzi-Agro\u0300","sequence":"additional","affiliation":[{"name":"From the Institute for Hematology, Erasmus University Rotterdam, The Netherlands; and Department of Experimental Medicine and Biochemical Sciences, University of Rome \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Lo\u0308wenberg","sequence":"additional","affiliation":[{"name":"From the Institute for Hematology, Erasmus University Rotterdam, The Netherlands; and Department of Experimental Medicine and Biochemical Sciences, University of Rome \u201cTor Vergata,\u201d Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud","family":"Delwel","sequence":"additional","affiliation":[{"name":"From the Institute for Hematology, Erasmus University Rotterdam, The Netherlands; and Department of Experimental Medicine and Biochemical 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