{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:13:52Z","timestamp":1789010032484,"version":"build-2803163510"},"reference-count":18,"publisher":"American Society of Hematology","issue":"8","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We treated 5 patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and multifocal bone lesions or diffuse bone marrow plasmacytic infiltration with high-dose therapy (HDT) and autologous blood stem cell transplantation. In all cases, the treatment produced remission of plasma cell proliferation associated with marked improvement in the patients' performance status, neurologic symptoms, and other manifestations of the syndrome. HDT with stem cell support should be investigated further as a therapeutic option in patients with POEMS syndrome and disseminated plasma cell dyscrasia.<\/jats:p>","DOI":"10.1182\/blood.v99.8.3057","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T18:33:52Z","timestamp":1034361232000},"page":"3057-3059","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":112,"title":["High-dose therapy and autologous blood stem cell transplantation in POEMS syndrome"],"prefix":"10.1182","volume":"99","author":[{"given":"Arnaud","family":"Jaccard","sequence":"first","affiliation":[{"name":"From the Hematology Unit, Centre Hospitalier Universitaire, Limoges, France, and Immuno-Hematology Unit, Ho\u0302pital Saint-Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Royer","sequence":"additional","affiliation":[{"name":"From the Hematology Unit, Centre Hospitalier Universitaire, Limoges, France, and Immuno-Hematology Unit, Ho\u0302pital Saint-Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Bordessoule","sequence":"additional","affiliation":[{"name":"From the Hematology Unit, Centre Hospitalier Universitaire, Limoges, France, and Immuno-Hematology Unit, Ho\u0302pital Saint-Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Brouet","sequence":"additional","affiliation":[{"name":"From the Hematology Unit, Centre Hospitalier Universitaire, Limoges, France, and Immuno-Hematology Unit, Ho\u0302pital Saint-Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Fermand","sequence":"additional","affiliation":[{"name":"From the Hematology Unit, Centre Hospitalier Universitaire, Limoges, France, and Immuno-Hematology Unit, Ho\u0302pital Saint-Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021219410328800_B1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1212\/WNL.34.6.712","article-title":"The Crow-Fukase syndrome: a study of 102 cases in Japan.","volume":"34","author":"Nakanishi","year":"1984","journal-title":"Neurology."},{"key":"2020021219410328800_B2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00005792-198007000-00006","article-title":"Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes: the POEMS syndrome: report on two cases and a review of the literature.","volume":"59","author":"Bardwick","year":"1980","journal-title":"Medicine."},{"key":"2020021219410328800_B3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00005792-198007000-00005","article-title":"Plasma cell neoplasia with peripheral polyneuropathy: a study of five cases and a review of the literature.","volume":"59","author":"Driedger","year":"1980","journal-title":"Medicine."},{"key":"2020021219410328800_B4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0002-9343(94)90350-6","article-title":"POEMS syndrome: a study of 25 cases and a review of the literature.","volume":"97","author":"Soubrier","year":"1994","journal-title":"Am J Med."},{"key":"2020021219410328800_B5","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1056\/NEJM199212313272705","article-title":"Plasma-cell dyscrasia with polyneuropathy. 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