{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:08:54Z","timestamp":1789852134865,"version":"4.0.1"},"reference-count":63,"publisher":"American Society of Hematology","issue":"9","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of angiogenesis in the growth and metastasis of solid tumors is well established. However, the role of angiogenesis in hematologic malignancies was only recently appreciated. We show that HTLV-I\u2013transformed T cells, but not HTLV-I\u2013negative CD4+T cells, secrete biologically active forms of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and, accordingly, induce angiogenesis in vitro. Furthermore, fresh ATL leukemic cells derived from patients with acute ATL produce VEGF and bFGF transcripts and proteins. The viral transactivator Tax activates the VEGF promoter, linking the induction of angiogenesis to viral gene expression. Angiogenesis is associated with the adhesion of HTLV-I\u2013transformed cells to endothelial cells and gap junction\u2013mediated heterocellular communication between the 2 cell types. Angiogenesis, cell adhesion, and communication likely contribute to the development of adult T-cell leukemia\u2013lymphoma and represent potential therapeutic targets.<\/jats:p>","DOI":"10.1182\/blood.v99.9.3383","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T14:33:52Z","timestamp":1034346832000},"page":"3383-3389","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":61,"title":["Human T-cell lymphotropic virus type 1\u2013transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells"],"prefix":"10.1182","volume":"99","author":[{"given":"Marwan E.","family":"El-Sabban","sequence":"first","affiliation":[{"name":"From the Departments of Human Morphology, Internal Medicine, and Biochemistry, Faculty of Medicine, American University of Beirut, Lebanon; CNRS UMR 8603, Necker Hospital, Paris; and CNRS UPR 9051, Ho\u0302pital St Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghida Abou","family":"Merhi","sequence":"additional","affiliation":[{"name":"From the Departments of Human Morphology, Internal Medicine, and Biochemistry, Faculty of Medicine, American University of Beirut, Lebanon; CNRS UMR 8603, Necker Hospital, Paris; and CNRS UPR 9051, Ho\u0302pital St Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hounaida Abi","family":"Haidar","sequence":"additional","affiliation":[{"name":"From the Departments of Human Morphology, Internal Medicine, and Biochemistry, Faculty of Medicine, American University of Beirut, Lebanon; CNRS UMR 8603, Necker Hospital, Paris; and CNRS UPR 9051, Ho\u0302pital St Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Arnulf","sequence":"additional","affiliation":[{"name":"From the Departments of Human Morphology, Internal Medicine, and Biochemistry, Faculty of Medicine, American University of Beirut, Lebanon; CNRS UMR 8603, Necker Hospital, Paris; and CNRS UPR 9051, Ho\u0302pital St Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Khoury","sequence":"additional","affiliation":[{"name":"From the Departments of Human Morphology, Internal Medicine, and Biochemistry, Faculty of Medicine, American University of Beirut, Lebanon; CNRS UMR 8603, Necker Hospital, Paris; and CNRS UPR 9051, Ho\u0302pital St Louis, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihane","family":"Basbous","sequence":"additional","affiliation":[{"name":"From the Departments of Human Morphology, Internal Medicine, and Biochemistry, Faculty of Medicine, American University of Beirut, Lebanon; CNRS UMR 8603, Necker Hospital, Paris; and CNRS UPR 9051, Ho\u0302pital St Louis, Paris, 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