{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:05:13Z","timestamp":1793390713246,"version":"4.5.0"},"reference-count":13,"publisher":"American Society of Hematology","issue":"13","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,5,23]]},"abstract":"<jats:title>Key Points<\/jats:title>\n                  <jats:p>Long-lived plasma cells secreting vaccinia-specific antibodies are detected in human bone marrow &gt;35 years after the eradication of smallpox. Long-lived plasma cells secreting vaccinia-specific antibodies are still able to express the B-lymphocyte antigen CD19.<\/jats:p>","DOI":"10.1182\/bloodadvances.2017004481","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T20:40:17Z","timestamp":1495226417000},"page":"835-838","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":55,"title":["Long-lived plasma cells in human bone marrow can be either CD19+ or CD19\u2013"],"prefix":"10.1182","volume":"1","author":[{"given":"Siggeir F.","family":"Brynjolfsson","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maziar","family":"Mohaddes","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"K\u00e4rrholm","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Jo","family":"Wick","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Biomedicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"issue":"4","key":"2019111607162080700_B1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.coi.2004.05.013","article-title":"Immunological memory to viral infection","volume":"16","author":"Slifka","year":"2004","journal-title":"Curr Opin Immunol"},{"issue":"3","key":"2019111607162080700_B2","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1128\/JVI.69.3.1895-1902.1995","article-title":"Bone marrow is a major site of long-term antibody production after acute viral infection","volume":"69","author":"Slifka","year":"1995","journal-title":"J Virol"},{"issue":"3","key":"2019111607162080700_B3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1074-7613(00)80541-5","article-title":"Humoral immunity due to long-lived plasma cells","volume":"8","author":"Slifka","year":"1998","journal-title":"Immunity"},{"issue":"6638","key":"2019111607162080700_B4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/40540","article-title":"Lifetime of plasma cells in the bone marrow","volume":"388","author":"Manz","year":"1997","journal-title":"Nature"},{"issue":"1","key":"2019111607162080700_B5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.immuni.2015.06.016","article-title":"Long-lived plasma cells are contained within the CD19(-)CD38(hi)CD138(+) subset in human bone marrow","volume":"43","author":"Halliley","year":"2015","journal-title":"Immunity"},{"issue":"11","key":"2019111607162080700_B6","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1182\/blood-2014-02-555169","article-title":"A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow","volume":"125","author":"Mei","year":"2015","journal-title":"Blood"},{"issue":"1-2","key":"2019111607162080700_B7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jim.2003.12.015","article-title":"Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system","volume":"286","author":"Crotty","year":"2004","journal-title":"J Immunol Methods"},{"issue":"9","key":"2019111607162080700_B8","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.4049\/jimmunol.1001587","article-title":"Rapid generation of rotavirus-specific human monoclonal antibodies from small-intestinal mucosa","volume":"185","author":"Di Niro","year":"2010","journal-title":"J Immunol"},{"issue":"20","key":"2019111607162080700_B9","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1182\/blood-2012-09-459289","article-title":"A functional BCR in human IgA and IgM plasma cells","volume":"121","author":"Pinto","year":"2013","journal-title":"Blood"},{"issue":"14","key":"2019111607162080700_B10","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1056\/NEJM199610033351404","article-title":"Rotavirus infection in infants as protection against subsequent infections","volume":"335","author":"Vel\u00e1zquez","year":"1996","journal-title":"N Engl J Med"},{"issue":"21","key":"2019111607162080700_B11","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1056\/NEJM197811232992103","article-title":"Epidemiology of human rotavirus Types 1 and 2 as studied by enzyme-linked immunosorbent assay","volume":"299","author":"Yolken","year":"1978","journal-title":"N Engl J Med"},{"key":"2019111607162080700_B12","doi-asserted-by":"crossref","first-page":"12698","DOI":"10.1038\/ncomms12698","article-title":"Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization","volume":"7","author":"Bemark","year":"2016","journal-title":"Nat Commun"},{"issue":"31","key":"2019111607162080700_B13","doi-asserted-by":"crossref","first-page":"29361","DOI":"10.1074\/jbc.M101935200","article-title":"Individual rotavirus-like particles containing 120 molecules of fluorescent protein are visible in living cells","volume":"276","author":"Charpilienne","year":"2001","journal-title":"J Biol Chem"}],"container-title":["Blood Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/1\/13\/835\/877148\/advances004481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/1\/13\/835\/877148\/advances004481.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:30:37Z","timestamp":1602117037000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article\/1\/13\/835\/15641\/Longlived-plasma-cells-in-human-bone-marrow-can-be"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,19]]},"references-count":13,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2017,5,23]]}},"URL":"https:\/\/doi.org\/10.1182\/bloodadvances.2017004481","relation":{},"ISSN":["2473-9529","2473-9537"],"issn-type":[{"value":"2473-9529","type":"print"},{"value":"2473-9537","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,19]]}}}