{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:10:15Z","timestamp":1784002215080,"version":"3.55.0"},"reference-count":12,"publisher":"American Society of Hematology","issue":"20","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,9,12]]},"abstract":"<jats:title>Key Points<\/jats:title>\n               <jats:p>Severely decreased ADAMTS13 unbound to VWF may play a key role in the pathogenesis of HELLP syndrome. A qualitative ADAMTS13 assay may be important for diagnosing HELLP syndrome.<\/jats:p>","DOI":"10.1182\/bloodadvances.2017006767","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T20:40:26Z","timestamp":1503520826000},"page":"1628-1631","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":12,"title":["Severe reduction of free-form ADAMTS13, unbound to von Willebrand factor, in plasma of patients with HELLP syndrome"],"prefix":"10.1182","volume":"1","author":[{"given":"Yoko","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-3126","authenticated-orcid":false,"given":"Masanori","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayami","family":"Isonishi","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Hori","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Sado","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"2019111618204028300_B1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","article-title":"Pathogenesis of preeclampsia","volume":"5","author":"Young","year":"2010","journal-title":"Annu Rev Pathol"},{"issue":"9","key":"2019111618204028300_B2","first-page":"1029","article-title":"Mild to moderate reduction of a von Willebrand factor cleaving protease (ADAMTS-13) in pregnant women with HELLP microangiopathic syndrome","volume":"88","author":"Lattuada","year":"2003","journal-title":"Haematologica"},{"issue":"12","key":"2019111618204028300_B3","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1111\/j.1538-7836.2006.02205.x","article-title":"Acute activation of the endothelium results in increased levels of active von Willebrand factor in hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome","volume":"4","author":"Hulstein","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"3","key":"2019111618204028300_B4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/bjh.12494","article-title":"ADAMTS13 deficiency in severe postpartum HELLP syndrome","volume":"163","author":"Pourrat","year":"2013","journal-title":"Br J Haematol"},{"issue":"7","key":"2019111618204028300_B5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/00001721-200310000-00005","article-title":"Factor VIII and von Willebrand factor changes during normal pregnancy and puerperium","volume":"14","author":"S\u00e1nchez-Luceros","year":"2003","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"3","key":"2019111618204028300_B6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1046\/j.1365-2141.2001.02808.x","article-title":"Ten years of prophylactic treatment with fresh-frozen plasma in a child with chronic relapsing thrombotic thrombocytopenic purpura as a result of a congenital deficiency of von Willebrand factor-cleaving protease","volume":"113","author":"Barbot","year":"2001","journal-title":"Br J Haematol"},{"issue":"12","key":"2019111618204028300_B7","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1111\/trf.12182","article-title":"ADAMTS13 unbound to larger von Willebrand factor multimers in cryosupernatant: implications for selection of plasma preparations for thrombotic thrombocytopenic purpura treatment","volume":"53","author":"Hori","year":"2013","journal-title":"Transfusion"},{"issue":"8","key":"2019111618204028300_B8","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1111\/j.1537-2995.2006.00914.x","article-title":"Novel monoclonal antibody-based enzyme immunoassay for determining plasma levels of ADAMTS13 activity","volume":"46","author":"Kato","year":"2006","journal-title":"Transfusion"},{"issue":"6016","key":"2019111618204028300_B9","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1136\/bmj.1.6016.994","article-title":"Factor-VIII-related antigen: measurement by enzyme immunoassay","volume":"1","author":"Bartlett","year":"1976","journal-title":"BMJ"},{"issue":"10","key":"2019111618204028300_B10","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1111\/trf.13182","article-title":"Poor responder to plasma exchange therapy in acquired thrombotic thrombocytopenic purpura is associated with ADAMTS13 inhibitor boosting: visualization of an ADAMTS13 inhibitor complex and its proteolytic clearance from plasma","volume":"55","author":"Isonishi","year":"2015","journal-title":"Transfusion"},{"issue":"2","key":"2019111618204028300_B11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-2003-38833","article-title":"Procoagulant and anticoagulant mechanisms in human placenta","volume":"29","author":"Lanir","year":"2003","journal-title":"Semin Thromb Hemost"},{"issue":"9","key":"2019111618204028300_B12","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1172\/JCI119388","article-title":"Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?","volume":"99","author":"Zhou","year":"1997","journal-title":"J Clin Invest"}],"container-title":["Blood Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/1\/20\/1628\/878532\/advances006767.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/1\/20\/1628\/878532\/advances006767.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T18:20:47Z","timestamp":1573928447000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article\/1\/20\/1628\/16270\/Severe-reduction-of-freeform-ADAMTS13-unbound-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":12,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2017,9,12]]}},"URL":"https:\/\/doi.org\/10.1182\/bloodadvances.2017006767","relation":{},"ISSN":["2473-9529","2473-9537"],"issn-type":[{"value":"2473-9529","type":"print"},{"value":"2473-9537","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]}}}