{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:48:11Z","timestamp":1790200091323,"version":"4.1.0"},"reference-count":49,"publisher":"American Society of Hematology","issue":"5","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,3,13]]},"abstract":"<jats:title>Key Points<\/jats:title><jats:p>A single rare DNMT3A mutation and recurrent amplification of ETS1, PTPN6, and TGFBR2 are identified in iMCD and UCD. Genetic alterations in oncogenes, tumor suppressors, and chromatin-remodeling genes are seen in FDCS.<\/jats:p>","DOI":"10.1182\/bloodadvances.2017009654","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T01:30:23Z","timestamp":1519954223000},"page":"481-491","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":57,"title":["Next-generation sequencing of idiopathic multicentric and unicentric Castleman disease and follicular dendritic cell sarcomas"],"prefix":"10.1182","volume":"2","author":[{"given":"Alexandra","family":"Nagy","sequence":"first","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Bhaduri","sequence":"additional","affiliation":[{"name":"Department of Regeneration Medicine, University of California San Francisco, San Francisco, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Shahmarvand","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahanbanoo","family":"Shahryari","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Zehnder","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Warnke","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Mughal","sequence":"additional","affiliation":[{"name":"Foundation Medicine Inc, Cambridge, MA; and"},{"name":"Department of Medicine, Tufts University Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraj","family":"Ali","sequence":"additional","affiliation":[{"name":"Foundation Medicine Inc, Cambridge, MA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-3440","authenticated-orcid":false,"given":"Robert S.","family":"Ohgami","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"issue":"8","key":"2019111616053072200_B1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1080\/02841860410002752","article-title":"Fifty years of multicentric Castleman\u2019s disease","volume":"43","author":"Waterston","year":"2004","journal-title":"Acta Oncol"},{"issue":"1","key":"2019111616053072200_B2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2141.2004.05311.x","article-title":"The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care","volume":"129","author":"Casper","year":"2005","journal-title":"Br J Haematol"},{"key":"2019111616053072200_B3","first-page":"320","article-title":"Thrombocytopenia with fever, chest ascites, hepatosplenomegaly, mild fibrosis in the bone marrow","volume":"51","author":"Takai","year":"2010","journal-title":"Rinsho Ketsueki"},{"issue":"1","key":"2019111616053072200_B4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3960\/jslrt.53.57","article-title":"Castleman-Kojima disease (TAFRO syndrome): a novel systemic inflammatory disease characterized by a constellation of symptoms, namely, thrombocytopenia, ascites (anasarca), microcytic anemia, myelofibrosis, renal dysfunction, and organomegaly: a status report and summary of Fukushima (6 June, 2012) and Nagoya meetings (22 September, 2012)","volume":"53","author":"Kawabata","year":"2013","journal-title":"J Clin Exp Hematop"},{"issue":"2","key":"2019111616053072200_B5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/ajh.24242","article-title":"Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease","volume":"91","author":"Iwaki","year":"2016","journal-title":"Am J Hematol"},{"issue":"6","key":"2019111616053072200_B6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/modpathol.2013.202","article-title":"Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease","volume":"27","author":"Chang","year":"2014","journal-title":"Mod Pathol"},{"issue":"19","key":"2019111616053072200_B7","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1182\/blood-2013-12-545087","article-title":"HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy","volume":"123","author":"Fajgenbaum","year":"2014","journal-title":"Blood"},{"issue":"2","key":"2019111616053072200_B8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/his.12416","article-title":"Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms","volume":"65","author":"Go","year":"2014","journal-title":"Histopathology"},{"issue":"1","key":"2019111616053072200_B9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/modpathol.2015.130","article-title":"Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-\u03baB regulatory genes","volume":"29","author":"Griffin","year":"2016","journal-title":"Mod Pathol"},{"issue":"10","key":"2019111616053072200_B10","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/modpathol.2016.102","article-title":"A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma","volume":"29","author":"Ozawa","year":"2016","journal-title":"Mod Pathol"},{"issue":"9","key":"2019111616053072200_B11","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/ng.3370","article-title":"Genomic analysis of mycosis fungoides and S\u00e9zary syndrome identifies recurrent alterations in TNFR2","volume":"47","author":"Ungewickell","year":"2015","journal-title":"Nat Genet"},{"issue":"24","key":"2019111616053072200_B12","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1182\/blood-2015-08-664649","article-title":"Integrated genomic DNA\/RNA profiling of hematologic malignancies in the clinical setting","volume":"127","author":"He","year":"2016","journal-title":"Blood"},{"issue":"12","key":"2019111616053072200_B13","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1182\/blood-2016-10-746933","article-title":"International, evidence-based consensus diagnostic criteria for HHV-8-negative\/idiopathic multicentric Castleman disease","volume":"129","author":"Fajgenbaum","year":"2017","journal-title":"Blood"},{"issue":"5826","key":"2019111616053072200_B14","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1126\/science.1140881","article-title":"Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF","volume":"316","author":"Maeda","year":"2007","journal-title":"Science"},{"issue":"5","key":"2019111616053072200_B15","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/leu.2015.263","article-title":"Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia","volume":"30","author":"Andersson","year":"2016","journal-title":"Leukemia"},{"issue":"15","key":"2019111616053072200_B16","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1182\/blood-2012-06-435297","article-title":"STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia","volume":"120","author":"Jerez","year":"2012","journal-title":"Blood"},{"issue":"20","key":"2019111616053072200_B17","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1056\/NEJMoa1114885","article-title":"Somatic STAT3 mutations in large granular lymphocytic leukemia","volume":"366","author":"Koskela","year":"2012","journal-title":"N Engl J Med"},{"issue":"1","key":"2019111616053072200_B18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40364-017-0081-z","article-title":"DNA methyltransferases and their roles in tumorigenesis","volume":"5","author":"Zhang","year":"2017","journal-title":"Biomark Res"},{"issue":"3","key":"2019111616053072200_B19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrc3895","article-title":"DNMT3A in haematological malignancies","volume":"15","author":"Yang","year":"2015","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"2019111616053072200_B20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1182\/bloodadvances.2016000760","article-title":"Mutational analysis of disease relapse in patients allografted for acute myeloid leukemia","volume":"1","author":"Quek","year":"2016","journal-title":"Blood Adv"},{"issue":"34","key":"2019111616053072200_B21","doi-asserted-by":"crossref","first-page":"26114","DOI":"10.1074\/jbc.M109.089433","article-title":"The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation","volume":"285","author":"Dhayalan","year":"2010","journal-title":"J Biol Chem"},{"issue":"20","key":"2019111616053072200_B22","doi-asserted-by":"crossref","first-page":"9048","DOI":"10.1128\/MCB.24.20.9048-9058.2004","article-title":"The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin","volume":"24","author":"Chen","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"1","key":"2019111616053072200_B23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ng.1009","article-title":"Dnmt3a is essential for hematopoietic stem cell differentiation","volume":"44","author":"Challen","year":"2011","journal-title":"Nat Genet"},{"issue":"6","key":"2019111616053072200_B24","doi-asserted-by":"crossref","first-page":"e18919","DOI":"10.1371\/journal.pone.0018919","article-title":"Structural and histone binding ability characterizations of human PWWP domains","volume":"6","author":"Wu","year":"2011","journal-title":"PLoS One"},{"key":"2019111616053072200_B25","doi-asserted-by":"crossref","first-page":"43592","DOI":"10.1038\/srep43592","article-title":"Epigenetic modifications of interleukin-6 in synovial fibroblasts from osteoarthritis patients","volume":"7","author":"Yang","year":"2017","journal-title":"Sci Rep"},{"issue":"19","key":"2019111616053072200_B26","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1073\/pnas.86.19.7547","article-title":"IgG1 plasmacytosis in interleukin 6 transgenic mice","volume":"86","author":"Suematsu","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"issue":"26","key":"2019111616053072200_B27","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N Engl J Med"},{"issue":"26","key":"2019111616053072200_B28","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"Genovese","year":"2014","journal-title":"N Engl J Med"},{"key":"2019111616053072200_B29","doi-asserted-by":"crossref","first-page":"11733","DOI":"10.1038\/ncomms11733","article-title":"ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation","volume":"7","author":"Hartmann","year":"2016","journal-title":"Nat Commun"},{"issue":"11","key":"2019111616053072200_B30","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: new and unexpected biological functions","volume":"14","author":"Yu","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"2019111616053072200_B31","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.3324\/haematol.2013.101543","article-title":"STAT3 mutations are present in aggressive B-cell lymphomas including a subset of diffuse large B-cell lymphomas with CD30 expression","author":"Ohgami","year":"2014","journal-title":"Haematologica"},{"issue":"11","key":"2019111616053072200_B32","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1038\/leu.2013.104","article-title":"STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia","volume":"27","author":"Ohgami","year":"2013","journal-title":"Leukemia"},{"issue":"2","key":"2019111616053072200_B33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5858\/arpa.2014-0374-RS","article-title":"Follicular dendritic cell sarcoma","volume":"140","author":"Wu","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"2019111616053072200_B34","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.immuni.2013.02.018","article-title":"Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice","volume":"38","author":"Abram","year":"2013","journal-title":"Immunity"},{"issue":"1","key":"2019111616053072200_B35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12890-015-0019-x","article-title":"Clinical spectrum of intrathoracic Castleman disease: a retrospective analysis of 48 cases in a single Chinese hospital","volume":"15","author":"Luo","year":"2015","journal-title":"BMC Pulm Med"},{"issue":"3","key":"2019111616053072200_B36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/gyno.1995.1146","article-title":"Overexpression of the protein tyrosine phosphatase, nonreceptor type 6 (PTPN6), in human epithelial ovarian cancer","volume":"57","author":"Mok","year":"1995","journal-title":"Gynecol Oncol"},{"issue":"2","key":"2019111616053072200_B37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/ijc.11336","article-title":"Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers","volume":"107","author":"Behrens","year":"2003","journal-title":"Int J Cancer"},{"issue":"55","key":"2019111616053072200_B38","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1038\/sj.onc.1204043","article-title":"Ets factors and regulation of the extracellular matrix","volume":"19","author":"Trojanowska","year":"2000","journal-title":"Oncogene"},{"issue":"18","key":"2019111616053072200_B39","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1007\/s00018-012-1243-7","article-title":"Review of Ets1 structure, function, and roles in immunity","volume":"70","author":"Garrett-Sinha","year":"2013","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"2019111616053072200_B40","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.3109\/10428194.2014.981670","article-title":"The transcription factor ETS1 in lymphomas: friend or foe?","volume":"56","author":"Testoni","year":"2015","journal-title":"Leuk Lymphoma"},{"issue":"2","key":"2019111616053072200_B41","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1023918026437","article-title":"Higher stromal expression of transforming growth factor-beta type II receptors is associated with poorer prognosis breast tumors","volume":"79","author":"Barlow","year":"2003","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"2019111616053072200_B42","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.00041.2003","article-title":"Molecular regulation of vascular smooth muscle cell differentiation in development and disease","volume":"84","author":"Owens","year":"2004","journal-title":"Physiol Rev"},{"issue":"5","key":"2019111616053072200_B43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1186\/s13058-014-0425-7","article-title":"Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis","volume":"16","author":"Novitskiy","year":"2014","journal-title":"Breast Cancer Res"},{"issue":"10","key":"2019111616053072200_B44","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.4049\/jimmunol.146.10.3437","article-title":"Transforming growth factor-beta regulation of IL-6 production by unstimulated and IL-1-stimulated human fibroblasts","volume":"146","author":"Elias","year":"1991","journal-title":"J Immunol"},{"issue":"43","key":"2019111616053072200_B45","doi-asserted-by":"crossref","first-page":"12238","DOI":"10.1073\/pnas.1614120113","article-title":"Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition","volume":"113","author":"Zhao","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"2019111616053072200_B46","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1097\/PAS.0000000000000197","article-title":"Indolent T-lymphoblastic proliferation with disseminated multinodal involvement and partial CD33 expression","volume":"38","author":"Ohgami","year":"2014","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"2019111616053072200_B47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/PAP.0b013e31828d17ec","article-title":"Indolent T-lymphoblastic proliferation (iT-LBP): a review of clinical and pathologic features and distinction from malignant T-lymphoblastic lymphoma","volume":"20","author":"Ohgami","year":"2013","journal-title":"Adv Anat Pathol"},{"issue":"11","key":"2019111616053072200_B48","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1097\/PAS.0b013e318264e223","article-title":"TdT+ T-lymphoblastic populations are increased in Castleman disease, in Castleman disease in association with follicular dendritic cell tumors, and in angioimmunoblastic T-cell lymphoma","volume":"36","author":"Ohgami","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"2019111616053072200_B49","first-page":"1","article-title":"Multiplexed ion beam imaging analysis for quantitation of protein expression in cancer tissue sections","volume":"0","author":"Rost","year":"2017","journal-title":"Lab Invest"}],"container-title":["Blood Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/2\/5\/481\/880359\/advances009654.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/2\/5\/481\/880359\/advances009654.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:12:20Z","timestamp":1693566740000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article\/2\/5\/481\/15787\/Nextgeneration-sequencing-of-idiopathic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,1]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,3,13]]}},"URL":"https:\/\/doi.org\/10.1182\/bloodadvances.2017009654","relation":{},"ISSN":["2473-9529","2473-9537"],"issn-type":[{"value":"2473-9529","type":"print"},{"value":"2473-9537","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,1]]}}}