{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:21:01Z","timestamp":1790796061026,"version":"4.1.0"},"reference-count":61,"publisher":"American Society of Hematology","issue":"6","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,3,27]]},"abstract":"<jats:title>Key Points<\/jats:title><jats:p>\u03b1 genes and CAR haplotypes independently impact hemolytic anemia severity; low G6PD-activity impacts anemia severity in CAR\/CAR patients. BEN\/BEN patients have a higher prevalence of the favorable BCL11A\/rs1427407 T allele and a better response to HU than CAR\/CAR patients.<\/jats:p>","DOI":"10.1182\/bloodadvances.2017014555","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T16:00:18Z","timestamp":1521475218000},"page":"626-637","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":33,"title":["Biological impact of \u03b1 genes, \u03b2 haplotypes, and G6PD activity in sickle cell anemia at baseline and with hydroxyurea"],"prefix":"10.1182","volume":"2","author":[{"given":"Fran\u00e7oise","family":"Bernaudin","sequence":"first","affiliation":[{"name":"Referral Center for Sickle Cell Disease, Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Arnaud","sequence":"additional","affiliation":[{"name":"Referral Center for Sickle Cell Disease, Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Kamdem","sequence":"additional","affiliation":[{"name":"Referral Center for Sickle Cell Disease, Department of Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Hau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Centre Hospitalier Intercommunal and University Paris Est, Cr\u00e9teil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Lelong","sequence":"additional","affiliation":[{"name":"Department of Hematology, Centre Hospitalier Intercommunal, Cr\u00e9teil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Epaud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Centre Hospitalier Intercommunal and University Paris Est, Cr\u00e9teil, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Pondarr\u00e9","sequence":"additional","affiliation":[{"name":"Referral Center for Sickle Cell Disease, Department of Pediatrics, and"},{"name":"INSERM\/Mondor Institute of Biomedical Research 955 Team 2, Laboratory of Excellence GR-Ex, Cr\u00e9teil, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Pissard","sequence":"additional","affiliation":[{"name":"INSERM\/Mondor Institute of Biomedical Research 955 Team 2, Laboratory of Excellence GR-Ex, Cr\u00e9teil, France; and"},{"name":"Department of Genetics, Henri Mondor Hospital, University Paris Est, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"issue":"23","key":"2019111616110601300_B1","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease. Life expectancy and risk factors for early death","volume":"330","author":"Platt","year":"1994","journal-title":"N Engl J Med"},{"issue":"1","key":"2019111616110601300_B2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.blre.2006.07.001","article-title":"Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes","volume":"21","author":"Kato","year":"2007","journal-title":"Blood Rev"},{"issue":"10","key":"2019111616110601300_B3","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1182\/blood-2008-03-143891","article-title":"G6PD deficiency, absence of alpha-thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia","volume":"112","author":"Bernaudin","year":"2008","journal-title":"Blood"},{"issue":"3","key":"2019111616110601300_B4","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1182\/blood.V71.3.748.748","article-title":"Effects of glucose-6-phosphate dehydrogenase deficiency upon sickle cell anemia","volume":"71","author":"Steinberg","year":"1988","journal-title":"Blood"},{"issue":"3","key":"2019111616110601300_B5","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1182\/blood-2009-04-216861","article-title":"Glucose 6 phosphate dehydrogenase deficiency is not associated with cerebrovascular disease in children with sickle cell anemia","volume":"114","author":"Rees","year":"2009","journal-title":"Blood"},{"issue":"5","key":"2019111616110601300_B6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/bjh.12590","article-title":"Impact of glucose-6-phosphate dehydrogenase deficiency on sickle cell anaemia expression in infancy and early childhood: a prospective study","volume":"163","author":"Benkerrou","year":"2013","journal-title":"Br J Haematol"},{"issue":"4","key":"2019111616110601300_B7","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1182\/blood-2010-06-293514","article-title":"Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort","volume":"117","author":"Bernaudin","year":"2011","journal-title":"Blood"},{"issue":"2","key":"2019111616110601300_B8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1365-2141.2010.08215.x","article-title":"Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia","volume":"150","author":"Nouraie","year":"2010","journal-title":"Br J Haematol"},{"issue":"5","key":"2019111616110601300_B9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1056\/NEJM198202043060504","article-title":"Concurrent sickle-cell anemia and alpha-thalassemia: effect on severity of anemia","volume":"306","author":"Embury","year":"1982","journal-title":"N Engl J Med"},{"issue":"24","key":"2019111616110601300_B10","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1056\/NEJM198206173062402","article-title":"The interaction of alpha-thalassemia and homozygous sickle-cell disease","volume":"306","author":"Higgs","year":"1982","journal-title":"N Engl J Med"},{"issue":"1","key":"2019111616110601300_B11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1172\/JCI111181","article-title":"Concurrent sickle cell anemia and alpha-thalassemia. Effect on pathological properties of sickle erythrocytes","volume":"73","author":"Embury","year":"1984","journal-title":"J Clin Invest"},{"issue":"2","key":"2019111616110601300_B12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1182\/blood.V62.2.286.bloodjournal622286","article-title":"Alpha-thalassemia is related to prolonged survival in sickle cell anemia","volume":"62","author":"Mears","year":"1983","journal-title":"Blood"},{"issue":"6","key":"2019111616110601300_B13","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1073\/pnas.81.6.1771","article-title":"Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa","volume":"81","author":"Pagnier","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2019111616110601300_B14","first-page":"333","article-title":"A novel sickle mutation of yet another origin in Africa: the Cameroon type","volume":"89","author":"Lapoum\u00e9roulie","year":"1992","journal-title":"Hum Genet"},{"issue":"7","key":"2019111616110601300_B15","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1073\/pnas.82.7.2111","article-title":"Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients","volume":"82","author":"Labie","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"issue":"14","key":"2019111616110601300_B16","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1056\/NEJM198504043121403","article-title":"Hematologically and genetically distinct forms of sickle cell anemia in Africa. The Senegal type and the Benin type","volume":"312","author":"Nagel","year":"1985","journal-title":"N Engl J Med"},{"issue":"4","key":"2019111616110601300_B17","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1182\/blood.V69.4.1026.1026","article-title":"The hematologic characteristics of sickle cell anemia bearing the Bantu haplotype: the relationship between G gamma and HbF level","volume":"69","author":"Nagel","year":"1987","journal-title":"Blood"},{"issue":"3","key":"2019111616110601300_B18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0889-8588(18)30426-X","article-title":"Beta s-gene-cluster haplotypes in sickle cell anemia. Clinical and hematologic features","volume":"5","author":"Powars","year":"1991","journal-title":"Hematol Oncol Clin North Am"},{"key":"2019111616110601300_B19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1100\/tsw.2009.10","article-title":"Genetic etiologies for phenotypic diversity in sickle cell anemia","volume":"9","author":"Steinberg","year":"2009","journal-title":"Sci World J"},{"issue":"1","key":"2019111616110601300_B20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1182\/blood.V84.1.331.331","article-title":"A potential regulatory region for the expression of fetal hemoglobin in sickle cell disease","volume":"84","author":"Pissard","year":"1994","journal-title":"Blood"},{"issue":"5909","key":"2019111616110601300_B21","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1126\/science.1165409","article-title":"Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A","volume":"322","author":"Sankaran","year":"2008","journal-title":"Science"},{"issue":"3","key":"2019111616110601300_B22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bcmd.2015.01.001","article-title":"BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia","volume":"54","author":"Sebastiani","year":"2015","journal-title":"Blood Cells Mol Dis"},{"issue":"27","key":"2019111616110601300_B23","doi-asserted-by":"crossref","first-page":"11346","DOI":"10.1073\/pnas.0611393104","article-title":"Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults","volume":"104","author":"Thein","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2019111616110601300_B24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2141.1993.tb04639.x","article-title":"Rapid analysis of -alpha 3.7 thalassaemia and alpha alpha alpha anti 3.7 triplication by enzymatic amplification analysis","volume":"83","author":"Dod\u00e9","year":"1993","journal-title":"Br J Haematol"},{"issue":"4","key":"2019111616110601300_B25","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3324\/haematol.2014.113886","article-title":"A genetic score for the prediction of beta-thalassemia severity","volume":"100","author":"Danjou","year":"2015","journal-title":"Haematologica"},{"issue":"3","key":"2019111616110601300_B26","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00043426-199023000-00022","article-title":"Beta S-gene-cluster haplotypes in sickle cell anemia: clinical implications","volume":"12","author":"Powars","year":"1990","journal-title":"Am J Pediatr Hematol Oncol"},{"issue":"4","key":"2019111616110601300_B27","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1182\/blood.V85.4.1111.bloodjournal8541111","article-title":"An analysis of fetal hemoglobin variation in sickle cell disease: the relative contributions of the X-linked factor, beta-globin haplotypes, alpha-globin gene number, gender, and age","volume":"85","author":"Chang","year":"1995","journal-title":"Blood"},{"issue":"1","key":"2019111616110601300_B28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1096-8652(199705)55:1<24::AID-AJH4>3.0.CO;2-5","article-title":"Sickle cell disorder, beta-globin gene cluster haplotypes and alpha-thalassemia in neonates and adults from Guadeloupe","volume":"55","author":"K\u00e9clard","year":"1997","journal-title":"Am J Hematol"},{"issue":"2","key":"2019111616110601300_B29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/(SICI)1096-8652(199610)53:2<72::AID-AJH3>3.0.CO;2-0","article-title":"Effect of alpha-thalassemia and beta-globin gene cluster haplotypes on the hematological and clinical features of sickle-cell anemia in Brazil","volume":"53","author":"Figueiredo","year":"1996","journal-title":"Am J Hematol"},{"issue":"2","key":"2019111616110601300_B30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/(SICI)1096-8652(200006)64:2<87::AID-AJH2>3.0.CO;2-B","article-title":"Determination of beta-globin gene cluster haplotypes and prevalence of alpha-thalassemia in sickle cell anemia patients in Venezuela","volume":"64","author":"Arends","year":"2000","journal-title":"Am J Hematol"},{"issue":"6","key":"2019111616110601300_B31","doi-asserted-by":"crossref","first-page":"e100516","DOI":"10.1371\/journal.pone.0100516","article-title":"The co-inheritance of alpha-thalassemia and sickle cell anemia is associated with better hematological indices and lower consultations rate in Cameroonian patients and could improve their survival","volume":"9","author":"Rumaney","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"2019111616110601300_B32","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000040950","article-title":"Sickle-cell disease in Brazzaville, Congo: genetical, hematological, biochemical and clinical aspects","volume":"101","author":"Mou\u00e9l\u00e9","year":"1999","journal-title":"Acta Haematol"},{"issue":"7","key":"2019111616110601300_B33","first-page":"684","article-title":"Homozygous sickle cell disease in Uganda and Jamaica a comparison of Bantu and Benin haplotypes","volume":"61","author":"Ndugwa","year":"2012","journal-title":"West Indian Med J"},{"issue":"10","key":"2019111616110601300_B34","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1182\/blood-2004-03-0835","article-title":"G6PD is indispensable for erythropoiesis after the embryonic-adult hemoglobin switch","volume":"104","author":"Paglialunga","year":"2004","journal-title":"Blood"},{"issue":"2","key":"2019111616110601300_B35","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1046\/j.1365-2141.2000.02353.x","article-title":"Platelet and leucocyte activation in childhood sickle cell disease: association with nocturnal hypoxaemia","volume":"111","author":"Inwald","year":"2000","journal-title":"Br J Haematol"},{"issue":"7","key":"2019111616110601300_B36","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/ajh.23457","article-title":"Genetic modifiers of sickle cell anemia in the BABY HUG cohort: influence on laboratory and clinical phenotypes","volume":"88","author":"Sheehan","year":"2013","journal-title":"Am J Hematol"},{"issue":"11","key":"2019111616110601300_B37","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1182\/blood.V86.11.4382a.bloodjournal86114382a","article-title":"Paradoxical increase of painful crises in sickle cell patients with alpha-thalassemia","volume":"86","author":"Billett","year":"1995","journal-title":"Blood"},{"issue":"289","key":"2019111616110601300_B38","first-page":"136","article-title":"Osteonecrosis of the humeral head in sickle cell disease","author":"Milner","year":"1993","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"2019111616110601300_B39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/03630268909003397","article-title":"Beta-cluster haplotypes, alpha-gene status, and hematological data from SS, SC, and S-beta-thalassemia patients in southern California","volume":"13","author":"Schroeder","year":"1989","journal-title":"Hemoglobin"},{"issue":"3","key":"2019111616110601300_B40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0889-8588(18)30426-X","article-title":"Beta s-gene-cluster haplotypes in sickle cell anemia. Clinical and hematologic features","volume":"5","author":"Powars","year":"1991","journal-title":"Hematol Oncol Clin North Am"},{"issue":"3","key":"2019111616110601300_B41","first-page":"202","article-title":"Sickle cell anemia: beta s-gene-cluster haplotypes as prognostic indicators of vital organ failure","volume":"28","author":"Powars","year":"1991","journal-title":"Semin Hematol"},{"issue":"1","key":"2019111616110601300_B42","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene-Frempong","year":"1998","journal-title":"Blood"},{"issue":"16","key":"2019111616110601300_B43","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1182\/blood-2011-05-349621","article-title":"Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure","volume":"119","author":"DeBaun","year":"2012","journal-title":"Blood"},{"issue":"10","key":"2019111616110601300_B44","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1182\/blood-2014-09-599852","article-title":"Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia","volume":"125","author":"Bernaudin","year":"2015","journal-title":"Blood"},{"issue":"3","key":"2019111616110601300_B45","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1542\/peds.103.3.640","article-title":"Silent cerebral infarcts in sickle cell anemia: a risk factor analysis","volume":"103","author":"Kinney","year":"1999","journal-title":"Pediatrics"},{"issue":"14","key":"2019111616110601300_B46","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1182\/blood-2015-10-675231","article-title":"Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities","volume":"127","author":"Bernaudin","year":"2016","journal-title":"Blood"},{"issue":"4","key":"2019111616110601300_B47","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1365-2141.2008.07375.x","article-title":"The presence of alpha-thalassaemia trait blunts the response to hydroxycarbamide in patients with sickle cell disease","volume":"143","author":"Vasavda","year":"2008","journal-title":"Br J Haematol"},{"issue":"10","key":"2019111616110601300_B48","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1182\/blood.V79.10.2555.2555","article-title":"Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia","volume":"79","author":"Charache","year":"1992","journal-title":"Blood"},{"key":"2019111616110601300_B49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bcmd.2016.11.002","article-title":"The role of BCL11A and HMIP-2 polymorphisms on endogenous and hydroxyurea induced levels of fetal hemoglobin in sickle cell anemia patients from southern Brazil","volume":"62","author":"Friedrisch","year":"2016","journal-title":"Blood Cells Mol Dis"},{"issue":"10019","key":"2019111616110601300_B50","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0140-6736(15)01041-7","article-title":"Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial","volume":"387","author":"Ware","year":"2016","journal-title":"Lancet"},{"issue":"2","key":"2019111616110601300_B51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0950-3536(11)80023-5","article-title":"Genetic epidemiology of the beta s gene","volume":"5","author":"Nagel","year":"1992","journal-title":"Baillieres Clin Haematol"},{"issue":"5","key":"2019111616110601300_B52","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/tmi.12689","article-title":"Sickle cell disease in western Sudan: genetic epidemiology and predictors of knowledge attitude and practices","volume":"21","author":"Daak","year":"2016","journal-title":"Trop Med Int Health"},{"issue":"6","key":"2019111616110601300_B53","first-page":"377","article-title":"beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya","volume":"66","author":"Ojwang","year":"1989","journal-title":"East Afr Med J"},{"issue":"3","key":"2019111616110601300_B54","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1751-553X.2011.01388.x","article-title":"Molecular analysis of the \u03b2-globin gene cluster haplotypes in a Sudanese population with sickle cell anaemia","volume":"34","author":"Elderdery","year":"2012","journal-title":"Int J Lab Hematol"},{"issue":"2-3","key":"2019111616110601300_B55","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000204653","article-title":"DNA polymorphism in the beta-globin gene cluster in Saudi Arabs: relation to severity of sickle cell anaemia","volume":"88","author":"el-Hazmi","year":"1992","journal-title":"Acta Haematol"},{"issue":"1","key":"2019111616110601300_B56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bcmd.2012.12.005","article-title":"Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype","volume":"51","author":"Ngo","year":"2013","journal-title":"Blood Cells Mol Dis"},{"issue":"4-6","key":"2019111616110601300_B57","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/03630269.2017.1414059","article-title":"Hb F levels in Indian sickle cell patients and association with the HBB locus variant rs10128556 (C>T), and the HBG XmnI (Arab-Indian) variant","volume":"41","author":"Bhanushali","year":"2017","journal-title":"Hemoglobin"},{"issue":"3","key":"2019111616110601300_B58","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJM199101173240306","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"324","author":"Beutler","year":"1991","journal-title":"N Engl J Med"},{"issue":"2","key":"2019111616110601300_B59","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/bcmd.2002.0490","article-title":"Hematologically important mutations: glucose-6-phosphate dehydrogenase","volume":"28","author":"Beutler","year":"2002","journal-title":"Blood Cells Mol Dis"},{"issue":"5","key":"2019111616110601300_B60","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.blre.2007.05.002","article-title":"G6PD deficiency: the genotype-phenotype association","volume":"21","author":"Mason","year":"2007","journal-title":"Blood Rev"},{"issue":"9","key":"2019111616110601300_B61","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1182\/blood.V98.9.2597","article-title":"Discrepancies between genotype and phenotype in hematology: an important frontier","volume":"98","author":"Beutler","year":"2001","journal-title":"Blood"}],"container-title":["Blood Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/2\/6\/626\/882700\/advances014555.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/2\/6\/626\/882700\/advances014555.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T03:57:55Z","timestamp":1719892675000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article\/2\/6\/626\/15790\/Biological-impact-of-%CE%B1-genes-%CE%B2-haplotypes-and-G6PD"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,19]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,3,27]]}},"URL":"https:\/\/doi.org\/10.1182\/bloodadvances.2017014555","relation":{},"ISSN":["2473-9529","2473-9537"],"issn-type":[{"value":"2473-9529","type":"print"},{"value":"2473-9537","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,19]]}}}