{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:27:36Z","timestamp":1790652456400,"version":"4.1.0"},"reference-count":61,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Infectious mononucleosis, caused by infection with the human gamma-herpesvirus Epstein-Barr virus (EBV), manifests with one of the strongest CD8+ T-cell responses described in humans. The resulting T-cell memory response controls EBV infection asymptomatically in the vast majority of persistently infected individuals. Whether and how dendritic cells (DCs) contribute to the priming of this near-perfect immune control remains unclear. Here we show that of all the human DC subsets, plasmacytoid DCs (pDCs) play a central role in the detection of EBV infection in vitro and in mice with reconstituted human immune system components. pDCs respond to EBV by producing the interferon (IFN) subtypes \u03b11, \u03b12, \u03b15, \u03b17, \u03b114, and \u03b117. However, the virus curtails this type I IFN production with its latent EBV gene products EBNA3A and EBNA3C. The induced type I IFNs inhibit EBV entry and the proliferation of latently EBV-transformed B cells but do not influence lytic reactivation of the virus in vitro. In vivo, exogenous IFN-\u03b114 and IFN-\u03b117, as well as pDC expansion, delay EBV infection and the resulting CD8+ T-cell expansion, but pDC depletion does not significantly influence EBV infection. Thus, consistent with the observation that primary immunodeficiencies compromising type I IFN responses affect only alpha- and beta-herpesvirus infections, we found that EBV elicits pDC responses that transiently suppress viral replication and attenuate CD8+ T-cell expansion but are not required to control primary infection.<\/jats:p>","DOI":"10.1182\/bloodadvances.2018025536","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T16:55:50Z","timestamp":1554483350000},"page":"1129-1144","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":44,"title":["Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile"],"prefix":"10.1182","volume":"3","author":[{"given":"Cornelia","family":"Gujer","sequence":"first","affiliation":[{"name":"Viral Immunobiology, Institute of Experimental Immunology, University of Z\u00fcrich, Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Murer","sequence":"additional","affiliation":[{"name":"Viral Immunobiology, Institute of Experimental Immunology, University of Z\u00fcrich, Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Viral Immunobiology, Institute of Experimental Immunology, University of Z\u00fcrich, Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danusia","family":"Vanoaica","sequence":"additional","affiliation":[{"name":"Viral Immunobiology, Institute of Experimental Immunology, University of Z\u00fcrich, Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Sutter","sequence":"additional","affiliation":[{"name":"Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Jacque","sequence":"additional","affiliation":[{"name":"LFB Biotechnologies, Lille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Fournier","sequence":"additional","affiliation":[{"name":"LFB Biotechnologies, Lille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kalchschmidt","sequence":"additional","affiliation":[{"name":"Genomics and Immunity, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zbinden","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology, University of Z\u00fcrich, Z\u00fcrich, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccarda","family":"Capaul","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology, University of Z\u00fcrich, Z\u00fcrich, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Dzionek","sequence":"additional","affiliation":[{"name":"Miltenyi Biotec GmbH, Bergisch Gladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mondon","sequence":"additional","affiliation":[{"name":"LFB Biotechnologies, Lille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Dittmer","sequence":"additional","affiliation":[{"name":"Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6419-1940","authenticated-orcid":false,"given":"Christian","family":"M\u00fcnz","sequence":"additional","affiliation":[{"name":"Viral Immunobiology, Institute of Experimental Immunology, University of Z\u00fcrich, Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"issue":"1","key":"2020021108280334600_B1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-pathol-012513-104656","article-title":"Gammaherpesviruses and lymphoproliferative disorders","volume":"9","author":"Cesarman","year":"2014","journal-title":"Annu Rev Pathol"},{"issue":"pt 1","key":"2020021108280334600_B2","first-page":"151","article-title":"EBV persistence\u2014introducing the virus","volume":"390","author":"Thorley-Lawson","year":"2015","journal-title":"Curr Top Microbiol 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