{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:05:49Z","timestamp":1776103549568,"version":"3.50.1"},"reference-count":36,"publisher":"American Society of Hematology","issue":"2","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antithymocyte globulin (ATG) is widely used to reduce acute graft-versus-host disease (aGVHD) and chronic GVHD (cGVHD). To clarify the different impacts of ATG for conditioning across different donor types, we retrospectively analyzed patients with acute leukemia (n = 6617) who underwent hematopoietic stem cell transplantation between 2008 and 2015 with ATG (n = 279) or without ATG (n = 6338). Because thymoglobulin is the only ATG drug approved for GVHD prophylaxis in Japan since September 2008, we included thymoglobulin alone in the present analysis. The survivors\u2019 median follow-up time was 1081 days. Patients were categorized into 5 groups: cord blood (CB; n = 1915), matched related donor (n = 1772), 1-antigen mismatched related donor (1-MMRD; n = 225), matched unrelated donor (MUD; n = 1742), and 1-allele mismatched unrelated donor (1-MMUD; n = 963). In multivariate analysis, ATG decreased overall survival (hazard ratio [HR], 1.403; P = .054) and GVHD-free\/relapse-free survival (GRFS) (HR, 1.458; P = .053) in association with increased nonrelapse mortality (NRM) (HR, 1.608; P = .03) with CB, whereas it improved GRFS (HR, 0.515; P &amp;lt; .01) and decreased grades II to IV aGVHD (HR, 0.576; P &amp;lt; .01), extensive cGVHD (HR, 0.460; P = .02), and NRM (HR, 0.545; P = .03) with 1-MMUD. ATG did not impact survival with 1-MMRD and MUD. The use of ATG in conditioning is beneficial due to the reduction in acute\/chronic GVHD without increasing NRM or disease relapse only in 1-MMUD transplantation. On the other hand, ATG is not recommended for CB transplantation.<\/jats:p>","DOI":"10.1182\/bloodadvances.2018025643","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T21:45:22Z","timestamp":1547070322000},"page":"105-115","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":29,"title":["Impacts of thymoglobulin in patients with acute leukemia in remission undergoing allogeneic HSCT from different donors"],"prefix":"10.1182","volume":"3","author":[{"given":"Manabu","family":"Wakamatsu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan;"},{"name":"Department of Hematology and Oncology, Children\u2019s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-8046","authenticated-orcid":false,"given":"Seitaro","family":"Terakura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuteru","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiyasu","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiwa","family":"Kanamori","sequence":"additional","affiliation":[{"name":"Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Sawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Hematology, Toranomon Hospital, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Nakamae","sequence":"additional","affiliation":[{"name":"Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Children\u2019s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5488-4364","authenticated-orcid":false,"given":"Makoto","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Atsuta","sequence":"additional","affiliation":[{"name":"Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan;"},{"name":"Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan; 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