{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T06:12:58Z","timestamp":1794031978005,"version":"4.8.0"},"reference-count":67,"publisher":"American Society of Hematology","issue":"9","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low bone mineral density (BMD) disproportionately affects people with sickle cell disease (SCD). Growth faltering is common in SCD, but most BMD studies in pediatric SCD cohorts fail to adjust for short stature. We examined low BMD prevalence in 6- to 18-year-olds enrolled in the Sickle Cell Clinical Research and Intervention Program (SCCRIP), an ongoing multicenter life span SCD cohort study initiated in 2014. We calculated areal BMD for chronological age and height-adjusted areal BMD (Ht-aBMD) z scores for the SCCRIP cohort, using reference data from healthy African American children and adolescents enrolled in the Bone Mineral Density in Childhood Study. We defined low BMD as Ht-aBMD z scores less than or equal to \u20132 and evaluated its associations with demographic and clinical characteristics by using logistic regression analyses. Of the 306 children and adolescents in our study cohort (mean age, 12.5 years; 50% female; 64% HbSS\/S\u03b20-thalassemia genotype; 99% African American), 31% had low areal BMD for chronological age z scores and 18% had low Ht-aBMD z scores. In multivariate analyses, low Ht-aBMD z scores associated with adolescence (odds ratio [OR], 7.7; 95% confidence interval [CI], 1.94-30.20), hip osteonecrosis (OR, 4.0; 95% CI, 1.02-15.63), chronic pain (OR, 10.4; 95% CI, 1.51-71.24), and hemoglobin (OR, 0.74; 95% CI, 0.57-0.96). Despite adjusting for height, nearly 20% of this pediatric SCD cohort still had very low BMD. As the SCCRIP cohort matures, we plan to prospectively evaluate the longitudinal relationship between Ht-aBMD z scores and markers of SCD severity and morbidity.<\/jats:p>","DOI":"10.1182\/bloodadvances.2018026047","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T20:45:45Z","timestamp":1557434745000},"page":"1476-1488","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":17,"title":["Height-corrected low bone density associates with severe outcomes in sickle cell disease: SCCRIP cohort study results"],"prefix":"10.1182","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3082-9114","authenticated-orcid":false,"given":"Oyebimpe O.","family":"Adesina","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Gurney","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Memphis, Memphis, TN;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolian","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Villavicencio","sequence":"additional","affiliation":[{"name":"Department of Hematology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7418-6632","authenticated-orcid":false,"given":"Jason R.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Department of Hematology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Chemaitilly","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatric Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue C.","family":"Kaste","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, and"},{"name":"Department of Oncology, St. Jude Children\u2019s Research Hospital, Memphis, TN;"},{"name":"Department of Radiology, University of Tennessee Health Science Center, Memphis, TN;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-7348","authenticated-orcid":false,"given":"Babette S.","family":"Zemel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA; and"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-7321","authenticated-orcid":false,"given":"Jane S.","family":"Hankins","sequence":"additional","affiliation":[{"name":"Department of 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