{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:24:26Z","timestamp":1792653866321,"version":"4.5.0"},"reference-count":50,"publisher":"American Society of Hematology","issue":"3","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antibody ligation of the murine neutrophil surface protein Ly6G disrupts neutrophil migration in some contexts but not others. We tested whether this variability reflected divergent dependence of neutrophil migration on \u03b22 integrins, adhesion molecules that interact with Ly6G at the neutrophil surface. In integrin-dependent murine arthritis, Ly6G ligation attenuated joint inflammation, even though mice lacking Ly6G altogether developed arthritis normally. By contrast, Ly6G ligation had no impact on integrin-independent neutrophil migration into inflamed lung. In peritoneum, the role of \u03b22 integrins varied with stimulus, proving dispensable for neutrophil entry in Escherichia coli peritonitis but contributory in interleukin 1 (IL-1)\u2013mediated sterile peritonitis. Correspondingly, Ly6G ligation attenuated only IL-1 peritonitis, disrupting the molecular association between integrins and Ly6G and inducing cell-intrinsic blockade restricted to integrin-dependent migration. Consistent with this observation, Ly6G ligation impaired integrin-mediated postadhesion strengthening for neutrophils arresting on activated cremaster endothelium in vivo. Together, these findings identify selective inhibition of integrin-mediated neutrophil emigration through Ly6G ligation, highlighting the marked site and stimulus specificity of \u03b22 integrin dependence in neutrophil migration.<\/jats:p>","DOI":"10.1182\/bloodadvances.2018026732","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T16:46:44Z","timestamp":1548780404000},"page":"256-267","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":22,"title":["Differential attenuation of \u03b22 integrin\u2013dependent and \u2013independent neutrophil migration by Ly6G ligation"],"prefix":"10.1182","volume":"3","author":[{"given":"Pierre","family":"Cunin","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women\u2019s Hospital,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui 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