{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:23:28Z","timestamp":1790637808240,"version":"4.1.0"},"reference-count":35,"publisher":"American Society of Hematology","issue":"13","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) is a phosphatase known to be a tumor suppressor gene in T-cell acute lymphoblastic leukemia (T-ALL). Because the full clinicobiologic characteristics of PTPN2 loss remain poorly reported, we aimed to provide a comprehensive analysis of PTPN2 deletions within a cohort of 430 patients, including 216 adults and 214 children treated according to the GRAALL03\/05 (#NCT00222027 and #NCT00327678) and the FRALLE2000 protocols, respectively. We used multiplex ligation-dependent probe amplification to identify an 8% incidence of PTPN2 deletion, which was comparable in adult (9%) and pediatric (6%) populations. PTPN2 deletions were significantly associated with an \u03b1\u03b2 lineage and TLX1 deregulation. Analysis of the mutational genotype of adult T-ALL revealed a positive correlation between PTPN2 deletions and gain-of-function alterations in the IL7R\/JAK-STAT signaling pathway as well as PHF6 and WT1 mutations. Of note, PTPN2 and PTEN (phosphatase and tensin homolog) deletions were mutually exclusive. Regarding treatment response, PTPN2-deleted T-ALLs were associated with a higher glucocorticoid response and a trend for improved survival in children, but not in adults, with a 5-year cumulative incidence of relapse of 8% for PTPN2-deleted pediatric cases vs 26% (P = .177).<\/jats:p>","DOI":"10.1182\/bloodadvances.2018028993","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T16:45:15Z","timestamp":1562172315000},"page":"1981-1988","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":17,"title":["Clinical and biological features of PTPN2-deleted adult and pediatric T-cell acute lymphoblastic leukemia"],"prefix":"10.1182","volume":"3","author":[{"given":"Marion","family":"Alcantara","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Cit\u00e9, Institut Necker-Enfants Malades, Institut National de Recherche M\u00e9dicale U1151, Laboratory of Onco-Hematology, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Simonin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Cit\u00e9, Institut Necker-Enfants Malades, Institut National de Recherche M\u00e9dicale U1151, Laboratory of Onco-Hematology, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France;"},{"name":"Department of Pediatric Hematology and Oncology, Assistance Publique\u2013H\u00f4pitaux de Paris, Groupe Hospitalier des H\u00f4pitaux Universitaires Est Parisien, Armand Trousseau Hospital, Paris, France;"},{"name":"Sorbonne Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 06, Unit\u00e9 Mixte de Recherche S 938, Centre de Recherche Saint-Antoine, Groupe de Recherche (GRC) Clinique n\u00b007, GRC My\u00e9loprolif\u00e9rations aigu\u00ebs et chroniques, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Lhermitte","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Cit\u00e9, Institut Necker-Enfants Malades, Institut National de Recherche M\u00e9dicale U1151, Laboratory of Onco-Hematology, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Touzart","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Cit\u00e9, Institut Necker-Enfants Malades, Institut National de Recherche M\u00e9dicale U1151, Laboratory of Onco-Hematology, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Emilie","family":"Dourthe","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Cit\u00e9, Institut Necker-Enfants Malades, Institut National de Recherche M\u00e9dicale U1151, Laboratory of Onco-Hematology, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France;"},{"name":"Department of Pediatric Hematology and Immunology, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Universitaire Robert-Debr\u00e9, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Latiri","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes Sorbonne Cit\u00e9, Institut Necker-Enfants Malades, Institut National de Recherche M\u00e9dicale U1151, Laboratory of Onco-Hematology, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Necker Enfants-Malades, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6573-1312","authenticated-orcid":false,"given":"Nathalie","family":"Grardel","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, Centre Hospitalier R\u00e9gional Universitaire de Lille, Lille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Michel","family":"Cayuela","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, Saint-Louis Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-8104","authenticated-orcid":false,"given":"Yves","family":"Chalandon","sequence":"additional","affiliation":[{"name":"Swiss Group for Clinical Cancer Research, Bern, H\u00f4pital Universitaire, Geneva, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Graux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain, Centre Hospitalier Universitaire, Namur, Yvoir, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-6768","authenticated-orcid":false,"given":"Herv\u00e9","family":"Dombret","sequence":"additional","affiliation":[{"name":"Adolescent and Young Adult Hematology Unit, Saint-Louis Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-850X","authenticated-orcid":false,"given":"Norbert","family":"Ifrah","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire d\u2019Angers, Angers, 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