{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:16:00Z","timestamp":1792790160078,"version":"4.5.0"},"reference-count":43,"publisher":"American Society of Hematology","issue":"14","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>FOXO1 has an oncogenic role in adult germinal center\u2013derived lymphomas, in which mutations, predominately within the AKT recognition motif, cause nuclear retention of FOXO1, resulting in increased cell proliferation. To determine the prevalence and distribution of FOXO1 mutations in pediatric Burkitt lymphoma (BL), we sequenced a large number of sporadic and endemic BL patient samples. We report a high frequency of FOXO1 mutations in both sporadic and endemic BL at diagnosis, occurring in 23\/78 (29%) and 48\/89 (54%) samples, respectively, as well as 8\/16 (50%) cases at relapse. Mutations of T24 were the most common in sporadic BL but were rare in endemic cases, in which mutations of residue S22, also within the AKT recognition motif, were the most frequent. FOXO1 mutations were almost always present in the major tumor cell clone but were not associated with outcome. Analysis of other recurrent mutations reported in BL revealed that FOXO1 mutations were associated with mutations of DDX3X and ARID1A, but not MYC, TCF3\/ID3, or members of the phosphatidylinositol 3-kinase signaling pathway. We further show common nuclear retention of the FOXO1 protein, irrespective of mutation status, suggesting alternative unknown mechanisms for maintaining FOXO1 transcriptional activity in BL. CRISPR\/Cas9 knockout of FOXO1 in an endemic cell line produced a significant decrease in cell proliferation, supporting an oncogenic role for FOXO1 in endemic BL. Thus, FOXO1 is frequently mutated in both sporadic and endemic BL and may offer a potential therapeutic target for pediatric BL patients worldwide.<\/jats:p>","DOI":"10.1182\/bloodadvances.2018029546","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T16:45:26Z","timestamp":1562949926000},"page":"2118-2127","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":30,"title":["Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif"],"prefix":"10.1182","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-5986","authenticated-orcid":false,"given":"Peixun","family":"Zhou","sequence":"first","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8045-822X","authenticated-orcid":false,"given":"Alex E.","family":"Blain","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-3833","authenticated-orcid":false,"given":"Alexander M.","family":"Newman","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masood","family":"Zaka","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Chagaluka","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, Queen Elizabeth Central Hospital, Blantyre, Malawi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filbert R.","family":"Adlar","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-3175","authenticated-orcid":false,"given":"Ugonna T.","family":"Offor","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"},{"name":"Department of Paediatric and Adolescent Haematology and Oncology, The Great North Children\u2019s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Broadbent","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis","family":"Chaytor","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Hall","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hettie","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Van Noorden","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Imperial College London, Hammersmith Hospital, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irvin","family":"Lampert","sequence":"additional","affiliation":[{"name":"Department of Histopathology, West Middlesex University Hospital, Isleworth, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bailey","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"},{"name":"Department of Paediatric and Adolescent Haematology and Oncology, The Great North Children\u2019s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-5900","authenticated-orcid":false,"given":"Elizabeth","family":"Molyneux","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, Queen Elizabeth Central Hospital, Blantyre, Malawi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8268-2812","authenticated-orcid":false,"given":"Chris M.","family":"Bacon","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"},{"name":"Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bomken","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"},{"name":"Department of Paediatric and Adolescent Haematology and Oncology, The Great North Children\u2019s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2198-8949","authenticated-orcid":false,"given":"Vikki","family":"Rand","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"issue":"6","key":"2020021108170725700_B1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00018-015-2112-y","article-title":"FOXO transcription factors in cancer development and therapy","volume":"73","author":"Coomans de Brach\u00e8ne","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"2020021108170725700_B2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.semcancer.2017.07.008","article-title":"FOXO in B-cell lymphopoiesis and B cell neoplasia","volume":"50","author":"Ushmorov","year":"2018","journal-title":"Semin Cancer Biol"},{"key":"2020021108170725700_B3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.semcancer.2018.01.005","article-title":"FOXOs in cancer immunity: Knowns and unknowns","volume":"50","author":"Deng","year":"2018","journal-title":"Semin Cancer Biol"},{"issue":"6","key":"2020021108170725700_B4","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.immuni.2015.10.015","article-title":"The FOXO1 transcription factor instructs the germinal center dark zone program","volume":"43","author":"Dominguez-Sola","year":"2015","journal-title":"Immunity"},{"issue":"6","key":"2020021108170725700_B5","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.immuni.2015.10.021","article-title":"PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones","volume":"43","author":"Sander","year":"2015","journal-title":"Immunity"},{"issue":"11","key":"2020021108170725700_B6","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.bbamcr.2011.06.002","article-title":"FoxO transcription factors; regulation by AKT and 14-3-3 proteins","volume":"1813","author":"Tzivion","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"2020021108170725700_B7","first-page":"925350","article-title":"FOXO transcription factors: their clinical significance and regulation","volume":"2014","author":"Wang","year":"2014","journal-title":"BioMed Res Int"},{"issue":"2","key":"2020021108170725700_B8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccr.2012.06.012","article-title":"Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis","volume":"22","author":"Sander","year":"2012","journal-title":"Cancer Cell"},{"issue":"2","key":"2020021108170725700_B9","doi-asserted-by":"crossref","first-page":"a014282","DOI":"10.1101\/cshperspect.a014282","article-title":"Oncogenic mechanisms in Burkitt lymphoma","volume":"4","author":"Schmitz","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6","key":"2020021108170725700_B10","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.ccr.2013.05.002","article-title":"SYK inhibition modulates distinct PI3K\/AKT-dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas","volume":"23","author":"Chen","year":"2013","journal-title":"Cancer Cell"},{"issue":"9","key":"2020021108170725700_B11","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1158\/1078-0432.CCR-16-1922","article-title":"Biological and clinical relevance of associated genomic alterations in MYD88 L265P and non-L265P-mutated diffuse large B-cell lymphoma: analysis of 361 cases","volume":"23","author":"Dubois","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"2","key":"2020021108170725700_B12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jmoldx.2017.11.010","article-title":"Assessment of capture and amplicon-based approaches for the development of a targeted next-generation sequencing pipeline to personalize lymphoma management","volume":"20","author":"Hung","year":"2018","journal-title":"J Mol Diagn"},{"issue":"1","key":"2020021108170725700_B13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13045-017-0438-7","article-title":"Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38\/07 prospective clinical trial cohort","volume":"10","author":"Juskevicius","year":"2017","journal-title":"J Hematol Oncol"},{"issue":"3","key":"2020021108170725700_B14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/leu.2017.251","article-title":"Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets","volume":"32","author":"Karube","year":"2018","journal-title":"Leukemia"},{"issue":"2","key":"2020021108170725700_B15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cell.2017.09.027","article-title":"Genetic and functional drivers of diffuse large B cell lymphoma","volume":"171","author":"Reddy","year":"2017","journal-title":"Cell"},{"issue":"15","key":"2020021108170725700_B16","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","article-title":"Genetics and pathogenesis of diffuse large B-cell lymphoma","volume":"378","author":"Schmitz","year":"2018","journal-title":"N Engl J Med"},{"issue":"18","key":"2020021108170725700_B17","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1182\/blood-2013-01-479865","article-title":"Analysis of FOXO1 mutations in diffuse large B-cell lymphoma","volume":"121","author":"Trinh","year":"2013","journal-title":"Blood"},{"issue":"12","key":"2020021108170725700_B18","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1158\/1078-0432.CCR-15-2305","article-title":"Next-generation sequencing in diffuse large B-cell lymphoma highlights molecular divergence and therapeutic opportunities: a LYSA Study","volume":"22","author":"Dubois","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"25","key":"2020021108170725700_B19","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1182\/blood-2018-06-856203","article-title":"Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells","volume":"132","author":"Kabrani","year":"2018","journal-title":"Blood"},{"issue":"10","key":"2020021108170725700_B20","doi-asserted-by":"crossref","first-page":"e1005158","DOI":"10.1371\/journal.ppat.1005158","article-title":"Distinct viral and mutational spectrum of endemic Burkitt lymphoma","volume":"11","author":"Abate","year":"2015","journal-title":"PLoS Pathog"},{"issue":"5","key":"2020021108170725700_B21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1158\/1541-7786.MCR-16-0305","article-title":"Comprehensive transcriptome and mutational profiling of endemic Burkitt lymphoma reveals EBV type-specific differences","volume":"15","author":"Kaymaz","year":"2017","journal-title":"Mol Cancer Res"},{"issue":"12","key":"2020021108170725700_B22","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/ng.2468","article-title":"The genetic landscape of mutations in Burkitt lymphoma","volume":"44","author":"Love","year":"2012","journal-title":"Nat Genet"},{"issue":"12","key":"2020021108170725700_B23","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/ng.2469","article-title":"Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing","volume":"44","author":"Richter","year":"2012","journal-title":"Nat Genet"},{"issue":"7418","key":"2020021108170725700_B24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature11378","article-title":"Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics","volume":"490","author":"Schmitz","year":"2012","journal-title":"Nature"},{"key":"2020021108170725700_B25","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow","year":"2008","edition":"4th ed"},{"issue":"7","key":"2020021108170725700_B26","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1182\/blood-2006-07-036665","article-title":"Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents","volume":"109","author":"Cairo","year":"2007","journal-title":"Blood"},{"issue":"6","key":"2020021108170725700_B27","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1365-2141.2008.07144.x","article-title":"Excellent survival following two courses of COPAD chemotherapy in children and adolescents with resected localized B-cell non-Hodgkin\u2019s lymphoma: results of the FAB\/LMB 96 international study","volume":"141","author":"Gerrard","year":"2008","journal-title":"Br J Haematol"},{"issue":"7","key":"2020021108170725700_B28","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1182\/blood-2006-07-036673","article-title":"Results of the randomized international FAB\/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients","volume":"109","author":"Patte","year":"2007","journal-title":"Blood"},{"issue":"1","key":"2020021108170725700_B29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1179\/146532809X402006","article-title":"Endemic Burkitt lymphoma: a 28-day treatment schedule with cyclophosphamide and intrathecal methotrexate","volume":"29","author":"Hesseling","year":"2009","journal-title":"Ann Trop Paediatr"},{"issue":"6","key":"2020021108170725700_B30","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/bjh.14440","article-title":"The use of anthracyclines in the treatment of endemic Burkitt lymphoma","volume":"177","author":"Molyneux","year":"2017","journal-title":"Br J Haematol"},{"issue":"2","key":"2020021108170725700_B31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1136\/jmg.2010.082081","article-title":"GeneScreen: a program for high-throughput mutation detection in DNA sequence electropherograms","volume":"48","author":"Carr","year":"2011","journal-title":"J Med Genet"},{"issue":"9","key":"2020021108170725700_B32","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"issue":"14","key":"2020021108170725700_B33","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"3","key":"2020021108170725700_B34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"1","key":"2020021108170725700_B35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat Biotechnol"},{"issue":"5","key":"2020021108170725700_B36","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"2020021108170725700_B37","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview version 2--a multiple sequence alignment editor and analysis workbench","volume":"25","author":"Waterhouse","year":"2009","journal-title":"Bioinformatics"},{"issue":"8","key":"2020021108170725700_B38","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat Methods"},{"issue":"9","key":"2020021108170725700_B39","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1158\/1078-0432.CCR-15-2123","article-title":"Genetic landscapes of relapsed and refractory diffuse large B-cell lymphomas","volume":"22","author":"Morin","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"12","key":"2020021108170725700_B40","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1182\/blood-2018-09-871418","article-title":"Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma","volume":"133","author":"Grande","year":"2019","journal-title":"Blood"},{"issue":"5","key":"2020021108170725700_B41","doi-asserted-by":"crossref","first-page":"e1423183","DOI":"10.1080\/2162402X.2017.1423183","article-title":"FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy","volume":"7","author":"Pyrzynska","year":"2018","journal-title":"OncoImmunology"},{"key":"2020021108170725700_B42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.semcancer.2017.11.017","article-title":"Re-evaluating the role of FOXOs in cancer","volume":"50","author":"Hornsveld","year":"2018","journal-title":"Semin Cancer Biol"},{"issue":"4","key":"2020021108170725700_B43","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.cell.2017.09.045","article-title":"Selective inhibition of FOXO1 activator\/repressor balance modulates hepatic glucose handling","volume":"171","author":"Langlet","year":"2017","journal-title":"Cell"}],"container-title":["Blood Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/3\/14\/2118\/1632116\/advances029546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/3\/14\/2118\/1632116\/advances029546.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T08:23:16Z","timestamp":1581409396000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article\/3\/14\/2118\/260101\/Sporadic-and-endemic-Burkitt-lymphoma-have"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,12]]},"references-count":43,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,7,23]]}},"URL":"https:\/\/doi.org\/10.1182\/bloodadvances.2018029546","relation":{},"ISSN":["2473-9529","2473-9537"],"issn-type":[{"value":"2473-9529","type":"print"},{"value":"2473-9537","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,12]]}}}