{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T03:17:04Z","timestamp":1787109424149,"version":"build-2736575974"},"reference-count":27,"publisher":"American Society of Hematology","issue":"21","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,12]]},"abstract":"<jats:title>Key Points<\/jats:title><jats:p>PTCy with additional immunosuppression using mostly PBSCs grafts showed a reduction of acute GVHD rate in matched sibling donor HSCT. GRFS was improved after PTCy compared with CsA-MTX.<\/jats:p>","DOI":"10.1182\/bloodadvances.2019000236","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T16:53:27Z","timestamp":1572972807000},"page":"3351-3359","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":45,"title":["Posttransplant cyclophosphamide vs cyclosporin A and methotrexate as GVHD prophylaxis in matched sibling transplantation"],"prefix":"10.1182","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-7774","authenticated-orcid":false,"given":"Mi","family":"Kwon","sequence":"first","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-1776","authenticated-orcid":false,"given":"Rebeca","family":"Bail\u00e9n","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Pascual-Casc\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Regional de M\u00e1laga, M\u00e1laga, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Gallardo-Morillo","sequence":"additional","affiliation":[{"name":"Hospital Regional de M\u00e1laga, M\u00e1laga, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-5180","authenticated-orcid":false,"given":"Abel","family":"Garc\u00eda Sola","sequence":"additional","affiliation":[{"name":"Hospital Regional de M\u00e1laga, M\u00e1laga, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascual","family":"Balsalobre","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sol\u00e1n","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-4913","authenticated-orcid":false,"given":"Nieves","family":"Dorado","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Serrano","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Mart\u00ednez-Laperche","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-9170","authenticated-orcid":false,"given":"Ismael","family":"Bu\u00f1o","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Anguita","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"},{"name":"Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"D\u00edez-Martin","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital General Universitario Gregorio Mara\u00f1on, Madrid, Spain;"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain;"},{"name":"Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"issue":"17","key":"2019111521035106500_B1","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1182\/blood-2010-11-319509","article-title":"Patient-reported quality of life is associated with severity of chronic graft-versus-host disease as measured by NIH criteria: report on baseline data from the Chronic GVHD Consortium","volume":"117","author":"Pidala","year":"2011","journal-title":"Blood"},{"issue":"9","key":"2019111521035106500_B2","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1158\/1078-0432.CCR-14-0586","article-title":"Impact of chronic graft-versus-host disease on late relapse and survival on 7,489 patients after myeloablative allogeneic hematopoietic cell transplantation for leukemia","volume":"21","author":"Boyiadzis","year":"2015","journal-title":"Clin Cancer Res"},{"issue":"12","key":"2019111521035106500_B3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1056\/NEJM198603203141201","article-title":"Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia","volume":"314","author":"Storb","year":"1986","journal-title":"N Engl J Med"},{"issue":"2","key":"2019111521035106500_B4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/bmt.2013.107","article-title":"Prophylaxis and treatment of GVHD: EBMT-ELN working group recommendations for a standardized practice [published correction appears in Bone Marrow Transplant. 2014;49(2):319]","volume":"49","author":"Ruutu","year":"2014","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"2019111521035106500_B5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbmt.2008.03.005","article-title":"HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide","volume":"14","author":"Luznik","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"issue":"16","key":"2019111521035106500_B6","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1182\/blood-2009-11-251595","article-title":"High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease","volume":"115","author":"Luznik","year":"2010","journal-title":"Blood"},{"issue":"25","key":"2019111521035106500_B7","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1182\/blood-2014-07-587477","article-title":"Single-agent GVHD prophylaxis with posttransplantation cyclophosphamide after myeloablative, HLA-matched BMT for AML, ALL, and MDS","volume":"124","author":"Kanakry","year":"2014","journal-title":"Blood"},{"issue":"5","key":"2019111521035106500_B8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.bbmt.2015.01.020","article-title":"Single-agent high-dose cyclophosphamide for graft-versus-host disease prophylaxis in human leukocyte antigen-matched reduced-intensity peripheral blood stem cell transplantation results in an unacceptably high rate of severe acute graft-versus-host disease","volume":"21","author":"Bradstock","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"2019111521035106500_B9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ejh.12541","article-title":"OCTET-CY: a phase II study to investigate the efficacy of post-transplant cyclophosphamide as sole graft-versus-host prophylaxis after allogeneic peripheral blood stem cell transplantation","volume":"96","author":"Holtick","year":"2016","journal-title":"Eur J Haematol"},{"issue":"11","key":"2019111521035106500_B10","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1182\/blood-2015-10-672071","article-title":"Posttransplantation cyclophosphamide for prevention of graft-versus-host disease after HLA-matched mobilized blood cell transplantation","volume":"127","author":"Mielcarek","year":"2016","journal-title":"Blood"},{"issue":"1","key":"2019111521035106500_B11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13045-018-0586-4","article-title":"Post-transplant cyclophosphamide for graft-versus-host disease prophylaxis in HLA matched sibling or matched unrelated donor transplant for patients with acute leukemia, on behalf of ALWP-EBMT","volume":"11","author":"Ruggeri","year":"2018","journal-title":"J Hematol Oncol"},{"issue":"5","key":"2019111521035106500_B12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/ejh.13030","article-title":"Risk-adapted GVHD prophylaxis with post-transplantation cyclophosphamide in adults after related, unrelated, and haploidentical transplantations","volume":"100","author":"Moiseev","year":"2018","journal-title":"Eur J Haematol"},{"issue":"6","key":"2019111521035106500_B13","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.bbmt.2018.01.031","article-title":"A modified post-transplant cyclophosphamide regimen, for unmanipulated haploidentical marrow transplantation, in acute myeloid leukemia: a multicenter study","volume":"24","author":"Chiusolo","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"issue":"23","key":"2019111521035106500_B14","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1182\/blood-2014-01-552984","article-title":"Validation and refinement of the disease risk index for allogeneic stem cell transplantation","volume":"123","author":"Armand","year":"2014","journal-title":"Blood"},{"issue":"29","key":"2019111521035106500_B15","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1200\/JCO.2013.53.8157","article-title":"Comorbidity-age index: a clinical measure of biologic age before allogeneic hematopoietic cell transplantation","volume":"32","author":"Sorror","year":"2014","journal-title":"J Clin Oncol"},{"issue":"6","key":"2019111521035106500_B16","first-page":"825","article-title":"1994 Consensus Conference on Acute GVHD Grading","volume":"15","author":"Przepiorka","year":"1995","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"2019111521035106500_B17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"2019111521035106500_B18","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/bmt.2015.305","article-title":"Definition of GvHD-free, relapse-free survival for registry-based studies: an ALWP-EBMT analysis on patients with AML in remission","volume":"51","author":"Ruggeri","year":"2016","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"2019111521035106500_B19","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O","article-title":"Estimation of failure probabilities in the presence of competing risks: new representations of old estimators","volume":"18","author":"Gooley","year":"1999","journal-title":"Stat Med"},{"issue":"10","key":"2019111521035106500_B20","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.bbmt.2017.06.011","article-title":"Quality of life after allogeneic hematopoietic cell transplantation according to affected organ and severity of chronic graft-versus-host disease","volume":"23","author":"Kurosawa","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"issue":"10","key":"2019111521035106500_B21","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1182\/blood-2016-09-737825","article-title":"Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide","volume":"129","author":"Kanakry","year":"2017","journal-title":"Blood"},{"issue":"5","key":"2019111521035106500_B22","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.bbmt.2015.01.026","article-title":"Phase II trial of graft-versus-host disease prophylaxis with post-transplantation cyclophosphamide after reduced-intensity busulfan\/fludarabine conditioning for hematological malignancies","volume":"21","author":"Alousi","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"2019111521035106500_B23","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bbmt.2016.12.636","article-title":"Post-transplant cyclophosphamide and tacrolimus-mycophenolate mofetil combination prevents graft-versus-host disease in allogeneic peripheral blood hematopoietic cell transplantation from HLA-matched donors","volume":"23","author":"Carnevale-Schianca","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"issue":"8","key":"2019111521035106500_B24","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.4049\/jimmunol.149.8.2668","article-title":"Interference with cyclophosphamide-induced skin allograft tolerance by cyclosporin A","volume":"149","author":"Nomoto","year":"1992","journal-title":"J Immunol"},{"issue":"6","key":"2019111521035106500_B25","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.bbmt.2018.04.004","article-title":"Teaching a young dog new tricks: modifications to the post-transplantation cyclophosphamide haploidentical transplantation platform","volume":"24","author":"Kanakry","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1-3","key":"2019111521035106500_B26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12026-009-8139-0","article-title":"High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation","volume":"47","author":"Luznik","year":"2010","journal-title":"Immunol Res"},{"issue":"211","key":"2019111521035106500_B27","doi-asserted-by":"crossref","first-page":"211ra157","DOI":"10.1126\/scitranslmed.3006960","article-title":"Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide","volume":"5","author":"Kanakry","year":"2013","journal-title":"Sci Transl Med"}],"container-title":["Blood Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/3\/21\/3351\/1505267\/advancesadv2019000236.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/bloodadvances\/article-pdf\/3\/21\/3351\/1505267\/advancesadv2019000236.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T14:17:32Z","timestamp":1695392252000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article\/3\/21\/3351\/422698\/Posttransplant-cyclophosphamide-vs-cyclosporin-A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,5]]},"references-count":27,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2019,11,12]]}},"URL":"https:\/\/doi.org\/10.1182\/bloodadvances.2019000236","relation":{},"ISSN":["2473-9529","2473-9537"],"issn-type":[{"value":"2473-9529","type":"print"},{"value":"2473-9537","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,5]]}}}