{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:23:10Z","timestamp":1793330590864,"version":"4.5.0"},"reference-count":30,"publisher":"American Society of Hematology","issue":"17","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We studied 1110 patients with \u03b2-thalassemia major aged \u226425 years who received transplants with grafts from HLA-matched related (n = 677; 61%), HLA-mismatched related (n = 78; 7%), HLA-matched unrelated (n = 252; 23%), and HLA-mismatched unrelated (n = 103; 9%) donors between 2000 and 2016. Ninety percent of transplants were performed in the last decade. Eight-five percent of patients received \u226520 transfusions and 88% were inadequately chelated. All patients received myeloablative-conditioning regimen. Overall and event-free survival were highest for patients aged \u22646 years and after HLA-matched related and HLA-matched unrelated donor transplantation. The 5-year probabilities of overall survival for patients aged \u22646 years, 7 to 15 years, and 16 to 25 years, adjusted for donor type and conditioning regimen were 90%, 84%, and 63%, respectively (P &amp;lt; .001). The corresponding probabilities for event-free survival were 86%, 80%, and 63% (P &amp;lt; .001). Overall and event-free survival did not differ between HLA-matched related and HLA-matched unrelated donor transplantation (89% vs 87% and 86% vs 82%, respectively). Corresponding probabilities after mismatched related and mismatched unrelated donor transplantation were 73% vs 83% and 70% vs 78%. In conclusion, if transplantation is considered as a treatment option it should be offered early (age \u22646 years). An HLA-matched unrelated donor is a suitable alternative if an HLA-matched relative is not available.<\/jats:p>","DOI":"10.1182\/bloodadvances.2019000291","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T16:49:24Z","timestamp":1567183764000},"page":"2562-2570","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":88,"title":["Related and unrelated donor transplantation for \u03b2-thalassemia major: results of an international survey"],"prefix":"10.1182","volume":"3","author":[{"given":"Chunfu","family":"Li","sequence":"first","affiliation":[{"name":"Nanfang Hospital, Southern Medical University, Guangzhou, China;"},{"name":"Nanfang-Chunfu Children\u2019s Institute of Hematology and Oncology, Taixin Hospital, Dongguan, 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