{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:10:42Z","timestamp":1790878242868,"version":"4.1.0"},"reference-count":20,"publisher":"American Society of Hematology","issue":"13","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with multiple myeloma (MM) who achieve minimal residual disease (MRD) negativity after upfront treatment have superior outcomes compared with those who remain MRD+. Recently, associations have been shown between specific commensal microbes and development of plasma cell disorders. Here, we report the association between intestinal microbiota composition and treatment outcome in MM. Microbiota composition of fecal samples collected from 34 MM patients after induction therapy and at the time of flow cytometry\u2013based bone marrow MRD testing was determined by 16S ribosomal RNA sequencing. We observed a higher relative abundance of Eubacterium hallii in the 16 MRD\u2212 patients relative to the 18 MRD+ patients. No association was observed between microbial relative abundance and autologous stem cell transplantation history or MM paraprotein isotype. No differences in microbiota \u03b1 diversity were observed between MRD\u2212 and MRD+ patients. The potential association of microbiota composition with treatment response in MM patients is an important parameter for additional correlative and clinical investigation.<\/jats:p>","DOI":"10.1182\/bloodadvances.2019032276","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T17:25:58Z","timestamp":1570728358000},"page":"2040-2044","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":78,"title":["Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition"],"prefix":"10.1182","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-9750","authenticated-orcid":false,"given":"Matthew J.","family":"Pianko","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Devlin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Littmann","sequence":"additional","affiliation":[{"name":"Lucille Castori Center for Microbes, Inflammation, and Cancer,"},{"name":"Sloan Kettering Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisara","family":"Chansakul","sequence":"additional","affiliation":[{"name":"Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Mastey","sequence":"additional","affiliation":[{"name":"Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-5382","authenticated-orcid":false,"given":"Emily","family":"Fontana","sequence":"additional","affiliation":[{"name":"Lucille Castori Center for Microbes, Inflammation, and Cancer,"},{"name":"Sloan Kettering Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilan","family":"Ling","sequence":"additional","affiliation":[{"name":"Lucille Castori Center for Microbes, Inflammation, and Cancer,"},{"name":"Sloan Kettering Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabet","family":"Tavitian","sequence":"additional","affiliation":[{"name":"Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Slingerland","sequence":"additional","affiliation":[{"name":"Sloan Kettering Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann E.","family":"Slingerland","sequence":"additional","affiliation":[{"name":"Sloan Kettering Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie","family":"Clurman","sequence":"additional","affiliation":[{"name":"Sloan Kettering Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-3724","authenticated-orcid":false,"given":"Antonio L. C.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Sloan Kettering Institute, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-8284","authenticated-orcid":false,"given":"Ying","family":"Taur","sequence":"additional","affiliation":[{"name":"Lucille Castori Center for Microbes, Inflammation, and Cancer,"},{"name":"Sloan Kettering Institute, and"},{"name":"Weill Cornell Medical Center, New York, NY; and"},{"name":"Infectious Diseases Service and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-9904","authenticated-orcid":false,"given":"Eric G.","family":"Pamer","sequence":"additional","affiliation":[{"name":"Lucille Castori Center for Microbes, Inflammation, and Cancer,"},{"name":"Sloan Kettering Institute, and"},{"name":"Weill Cornell Medical Center, New York, NY; and"},{"name":"Infectious Diseases Service and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-7625","authenticated-orcid":false,"given":"Jonathan U.","family":"Peled","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical Center, New York, NY; and"},{"name":"Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0696-4401","authenticated-orcid":false,"given":"Marcel R. 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