{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:20:35Z","timestamp":1787019635438,"version":"build-2736575974"},"reference-count":31,"publisher":"American Society of Hematology","issue":"2","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hispanic children have a higher incidence of acute lymphoblastic leukemia (ALL) and inferior treatment outcomes relative to non-Hispanic White children. We previously reported that Hispanic children with ALL had lower risk of fracture and osteonecrosis. To unravel the genetic root of such ethnic differences, we genotyped 449 patients from the DFCI 05-001 cohort and analyzed their ancestry. Patients with discordant clinical and genetic ancestral groups were reclassified, and those with unknown ancestry were reassigned on the basis of genetic estimates. Both clinical and genetic ancestries were analyzed in relation to risk of bone toxicities and survival outcomes. Consistent with clinically reported race\/ethnicity, genetically defined Hispanic and Black patients had significantly lower risk of fracture (Hispanic: subdistribution hazard ratio [SHR], 0.42; 95% confidence interval [CI], 0.22-0.81; P = .01; Black: SHR, 0.28; 95% CI, 0.10-0.75; P = .01), and osteonecrosis (Hispanic: SHR, 0.12; 95% CI, 0.02-0.93; P = .04; Black: SHR, 0.24; 95% CI, 0.08-0.78; P = .02). The lower risk was driven by African but not Native American or Asian ancestry. In addition, patients with a higher percentage of Native American ancestry had significantly poorer overall survival and event-free survival. Our study revealed that the lower risk of bone toxicities among Black and Hispanic children treated for ALL was attributed, in part, to the percentage of African ancestry in their genetic admixture. The findings provide suggestive evidence for the protective effects of genetic factors associated with African decent against bone damage caused by ALL treatment and clues for future studies to identify underlying biological mechanisms.<\/jats:p>","DOI":"10.1182\/bloodadvances.2020003060","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T11:40:13Z","timestamp":1611142813000},"page":"451-458","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":12,"title":["Genetic ancestry and skeletal toxicities among childhood acute lymphoblastic leukemia patients in the DFCI 05-001 cohort"],"prefix":"10.1182","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9442-1313","authenticated-orcid":false,"given":"Song","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY;"},{"name":"Jacob School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-6675","authenticated-orcid":false,"given":"Qianqian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3525-8015","authenticated-orcid":false,"given":"Peter D.","family":"Cole","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian H.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Pathology, Boston Children\u2019s Hospital, Boston, MA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine M.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/Stem Cell Transplantation, Columbia University Irving Medical Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-5582","authenticated-orcid":false,"given":"Elena J.","family":"Ladas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/Stem Cell Transplantation, Columbia University Irving Medical Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-6560","authenticated-orcid":false,"given":"Uma H.","family":"Athale","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, McMaster University, Hamilton, ON, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Clavell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, San Jorge Children\u2019s Hospital, San Juan, Puerto Rico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Laverdiere","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Hospital Sainte-Justine, University of Montreal, Montreal, QC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Leclerc","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Hospital Sainte-Justine, University of Montreal, Montreal, QC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Michon","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Centre Hospitalier de l\u2019Universit\u00e9 Laval, Quebec City, QC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall A.","family":"Schorin","sequence":"additional","affiliation":[{"name":"Inova Fairfax Hospital for Children, Falls Church, VA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-4812","authenticated-orcid":false,"given":"Jennifer J. 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