{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:53:27Z","timestamp":1792634007668,"version":"4.5.0"},"reference-count":56,"publisher":"American Society of Hematology","issue":"23","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Non-Hodgkin B-cell lymphomas (B-NHL) mainly develop within lymph nodes as aggregates of tumor cells densely packed with their surrounding microenvironment, creating a tumor niche specific to each lymphoma subtypes. In vitro preclinical models mimicking biomechanical forces, cellular microenvironment, and 3D organization of B-cell lymphomas remain scarce, while all these parameters are key determinants of lymphomagenesis and drug resistance. Using a microfluidic method based on cell encapsulation inside permeable, elastic, and hollow alginate microspheres, we developed a new tunable 3D model incorporating lymphoma B cells, extracellular matrix (ECM), and\/or tonsil stromal cells (TSC). Under 3D confinement, lymphoma B cells were able to form cohesive spheroids resulting from overexpression of ECM components. Moreover, lymphoma B cells and TSC dynamically formed self-organized 3D spheroids favoring tumor cell growth. 3D culture induced resistance to the classical chemotherapeutic agent doxorubicin, but not to the BCL2 inhibitor ABT-199, identifying this approach as a relevant in\u00a0vitro model to assess the activity of therapeutic agents in B-NHL. RNA-sequence analysis highlighted the synergy of 3D, ECM, and TSC in upregulating similar pathways in malignant B cells in\u00a0vitro than those overexpressed in primary lymphoma B cells in situ. Finally, our 3D model including ECM and TSC allowed long-term in\u00a0vitro survival of primary follicular lymphoma B cells. In conclusion, we propose a new high-throughput 3D model mimicking lymphoma tumor niche and making it possible to study the dynamic relationship between lymphoma B cells and their microenvironment and to screen new anti-cancer drugs.<\/jats:p>","DOI":"10.1182\/bloodadvances.2020003949","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T09:45:49Z","timestamp":1632476749000},"page":"5372-5386","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":42,"title":["A novel 3D culture model recapitulates primary FL B-cell features and promotes their survival"],"prefix":"10.1182","volume":"5","author":[{"given":"Claire","family":"Lamaison","sequence":"first","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR) S1236, University of Rennes, Institut National de la Sant\u00e9 et de la recherche M\u00e9dicale (INSERM), Etablissement Fran\u00e7ais du sang, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-354X","authenticated-orcid":false,"given":"Simon","family":"Latour","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM U1218 ACTION, Centre National de la Recherche Scientifique (CNRS), Bordeaux, France;"},{"name":"Institut Bergoni\u00e9, Comprehensive Cancer Centre, Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"H\u00e9laine","sequence":"additional","affiliation":[{"name":"University of Bordeaux, CNRS UMR 5298 LP2N, Laboratoire Photonique Num\u00e9rique et Nanosciences, Institut d\u2019Optique Graduate School, Talence, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2408-4344","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Le Morvan","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM U1218 ACTION, Centre National de la Recherche Scientifique (CNRS), Bordeaux, France;"},{"name":"Institut Bergoni\u00e9, Comprehensive Cancer Centre, Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Saint-Vanne","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR) S1236, University of Rennes, Institut National de la Sant\u00e9 et de la recherche M\u00e9dicale (INSERM), Etablissement Fran\u00e7ais du sang, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Mahouche","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM U1218 ACTION, Centre National de la Recherche Scientifique (CNRS), Bordeaux, France;"},{"name":"Institut Bergoni\u00e9, Comprehensive Cancer Centre, Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-7888","authenticated-orcid":false,"given":"C\u00e9line","family":"Monvoisin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR) S1236, University of Rennes, Institut National de la Sant\u00e9 et de la recherche M\u00e9dicale (INSERM), Etablissement Fran\u00e7ais du sang, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Dussert","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM U1218 ACTION, Centre National de la Recherche Scientifique (CNRS), Bordeaux, France;"},{"name":"Institut Bergoni\u00e9, Comprehensive Cancer Centre, Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-8135","authenticated-orcid":false,"given":"La\u00ebtitia","family":"Andrique","sequence":"additional","affiliation":[{"name":"University of Bordeaux, TBMCore VoxCell facility, Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Deleurme","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR) S1236, University of Rennes, Institut National de la Sant\u00e9 et de la recherche M\u00e9dicale (INSERM), Etablissement Fran\u00e7ais du sang, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Dessauge","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR) S1236, University of Rennes, Institut National de la Sant\u00e9 et de la recherche M\u00e9dicale (INSERM), Etablissement Fran\u00e7ais du sang, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Pangault","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR) S1236, University of Rennes, Institut National de la Sant\u00e9 et de la recherche M\u00e9dicale (INSERM), Etablissement Fran\u00e7ais du sang, Rennes, France;"},{"name":"P\u00f4le de Biologie, Centre Hopsitalo-Universitaire Pontchaillou, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Baulande","sequence":"additional","affiliation":[{"name":"Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris Sciences et Lettres Research University, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Legoix","sequence":"additional","affiliation":[{"name":"Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, Paris Sciences et Lettres Research University, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-6145","authenticated-orcid":false,"given":"Marine","family":"Seffals","sequence":"additional","affiliation":[{"name":"University of Rennes, INSERM, CNRS, Unit\u00e9 Mixte de Service Biosit, Core Facility H2P2, Rennes, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Broca-Brisson","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM U1218 ACTION, Centre National de la Recherche Scientifique (CNRS), Bordeaux, France;"},{"name":"Institut Bergoni\u00e9, Comprehensive Cancer Centre, Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e9vin","family":"Alessandri","sequence":"additional","affiliation":[{"name":"University of Bordeaux, CNRS UMR 5298 LP2N, Laboratoire Photonique Num\u00e9rique et Nanosciences, Institut d\u2019Optique Graduate School, Talence, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-7679","authenticated-orcid":false,"given":"Martina","family":"Carlotti","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM U1053 BARITON, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Soubeyran","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM U1218 ACTION, Centre National de la Recherche Scientifique (CNRS), Bordeaux, France;"},{"name":"Institut Bergoni\u00e9, Comprehensive Cancer Centre, Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-0850","authenticated-orcid":false,"given":"Jean-Philippe","family":"Merlio","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM U1053 BARITON, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-9632","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Mourcin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR) S1236, University of Rennes, Institut National de la Sant\u00e9 et de la recherche M\u00e9dicale (INSERM), Etablissement Fran\u00e7ais du sang, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4615-9431","authenticated-orcid":false,"given":"Pierre","family":"Nassoy","sequence":"additional","affiliation":[{"name":"University of Bordeaux, CNRS UMR 5298 LP2N, Laboratoire Photonique Num\u00e9rique et Nanosciences, Institut d\u2019Optique Graduate School, Talence, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9004-0118","authenticated-orcid":false,"given":"Ga\u00eblle","family":"Recher","sequence":"additional","affiliation":[{"name":"University of Bordeaux, CNRS UMR 5298 LP2N, Laboratoire Photonique Num\u00e9rique et Nanosciences, Institut d\u2019Optique Graduate School, Talence, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-917X","authenticated-orcid":false,"given":"Karin","family":"Tarte","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR) S1236, University of Rennes, Institut National de la Sant\u00e9 et de la recherche M\u00e9dicale (INSERM), Etablissement Fran\u00e7ais du sang, Rennes, France;"},{"name":"P\u00f4le de Biologie, Centre Hopsitalo-Universitaire Pontchaillou, Rennes, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-9945","authenticated-orcid":false,"given":"Laurence","family":"Bresson-Bepoldin","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM U1218 ACTION, Centre National de la Recherche Scientifique (CNRS), Bordeaux, France;"},{"name":"Institut Bergoni\u00e9, Comprehensive Cancer Centre, Bordeaux, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"issue":"11","key":"2021120916264119300_B1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/bjc.2011.450","article-title":"Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network","volume":"105","author":"Smith","year":"2011","journal-title":"Br J Cancer."},{"issue":"6","key":"2021120916264119300_B2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3322\/caac.21357","article-title":"2016 US lymphoid malignancy statistics by World Health Organization subtypes","volume":"66","author":"Teras","year":"2016","journal-title":"CA Cancer J Clin."},{"issue":"4","key":"2021120916264119300_B3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nrc.2017.127","article-title":"From genetics to the clinic: a translational perspective on follicular lymphoma","volume":"18","author":"Huet","year":"2018","journal-title":"Nat Rev Cancer."},{"issue":"6769","key":"2021120916264119300_B4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature."},{"issue":"1","key":"2021120916264119300_B5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood-2014-05-577189","article-title":"Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity","volume":"125","author":"Sehn","year":"2015","journal-title":"Blood."},{"issue":"1","key":"2021120916264119300_B6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/35094059","article-title":"Putting tumours in context","volume":"1","author":"Bissell","year":"2001","journal-title":"Nat Rev Cancer."},{"issue":"8","key":"2021120916264119300_B7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrc3774","article-title":"The tumour microenvironment in B cell lymphomas","volume":"14","author":"Scott","year":"2014","journal-title":"Nat Rev Cancer."},{"issue":"4","key":"2021120916264119300_B8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/MOH.0000000000000440","article-title":"Microenvironment signaling driving lymphomagenesis","volume":"25","author":"Verdi\u00e8re","year":"2018","journal-title":"Curr Opin Hematol."},{"issue":"21","key":"2021120916264119300_B9","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1056\/NEJMoa041869","article-title":"Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells","volume":"351","author":"Dave","year":"2004","journal-title":"N Engl J Med."},{"issue":"11","key":"2021120916264119300_B10","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1182\/blood-2011-08-370908","article-title":"Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes","volume":"119","author":"Guilloton","year":"2012","journal-title":"Blood."},{"issue":"18","key":"2021120916264119300_B11","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1182\/blood-2016-08-737239","article-title":"IL-4\/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma","volume":"129","author":"Pandey","year":"2017","journal-title":"Blood."},{"issue":"8","key":"2021120916264119300_B12","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.immuni.2021.05.019","article-title":"Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape","volume":"54","author":"Mourcin","year":"2021","journal-title":"Immunity."},{"issue":"5","key":"2021120916264119300_B13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3324\/haematol.2015.139493","article-title":"Role of the tumor microenvironment in mature B-cell lymphoid malignancies","volume":"101","author":"Fowler","year":"2016","journal-title":"Haematologica."},{"issue":"22","key":"2021120916264119300_B14","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1056\/NEJMoa0802885","article-title":"Stromal gene signatures in large-B-cell lymphomas","volume":"359","author":"Lenz","year":"2008","journal-title":"N Engl J Med."},{"issue":"7","key":"2021120916264119300_B15","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","article-title":"Modeling Development and Disease with Organoids","volume":"165","author":"Clevers","year":"2016","journal-title":"Cell."},{"key":"2021120916264119300_B16","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3389\/fimmu.2019.01943","article-title":"A tridimensional model for NK cell-mediated ADCC of follicular lymphoma","volume":"10","author":"Decaup","year":"2019","journal-title":"Front Immunol."},{"issue":"1","key":"2021120916264119300_B17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ajpath.2013.09.018","article-title":"Cell growth in aggregates determines gene expression, proliferation, survival, chemoresistance, and sensitivity to immune effectors in follicular lymphoma","volume":"184","author":"Gravelle","year":"2014","journal-title":"Am J Pathol."},{"issue":"7","key":"2021120916264119300_B18","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.3390\/cancers13071490","article-title":"3D model characterization by 2D and 3D imaging in t(14;18)-positive B-NHL: perspectives for In\u00a0vitro drug screens in follicular lymphoma","volume":"13","author":"Gava","year":"2021","journal-title":"Cancers (Basel)."},{"key":"2021120916264119300_B19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.biomaterials.2015.09.007","article-title":"Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells","volume":"73","author":"Tian","year":"2015","journal-title":"Biomaterials."},{"key":"2021120916264119300_B20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/bs.mcb.2018.05.007","article-title":"3D in\u00a0vitro microvascular model-based lymphoma model","volume":"146","author":"Mannino","year":"2018","journal-title":"Methods Cell Biol."},{"key":"2021120916264119300_B21","doi-asserted-by":"crossref","first-page":"605231","DOI":"10.3389\/fimmu.2020.605231","article-title":"Developing a 3D B cell lymphoma culture system to model antibody therapy","volume":"11","author":"Foxall","year":"2021","journal-title":"Front Immunol."},{"issue":"37","key":"2021120916264119300_B22","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.1073\/pnas.1309482110","article-title":"Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in\u00a0vitro","volume":"110","author":"Alessandri","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"issue":"9","key":"2021120916264119300_B23","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1039\/C6LC00133E","article-title":"A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC)","volume":"16","author":"Alessandri","year":"2016","journal-title":"Lab Chip."},{"issue":"1","key":"2021120916264119300_B24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1039\/C6LC00848H","article-title":"Controlled production of sub-millimeter liquid core hydrogel capsules for parallelized 3D cell culture","volume":"17","author":"Dom\u00e9jean","year":"2016","journal-title":"Lab Chip."},{"issue":"2","key":"2021120916264119300_B25","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1182\/blood-2006-05-020800","article-title":"Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis","volume":"109","author":"Am\u00e9-Thomas","year":"2007","journal-title":"Blood."},{"issue":"2","key":"2021120916264119300_B26","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1158\/1078-0432.CCR-18-1153","article-title":"Pan-HDAC inhibitors restore PRDM1 response to IL21 in CREBBP-mutated follicular lymphoma","volume":"25","author":"Desmots","year":"2019","journal-title":"Clin Cancer Res."},{"issue":"1","key":"2021120916264119300_B27","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.18632\/oncotarget.13857","article-title":"Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment","volume":"8","author":"D\u00e4ster","year":"2017","journal-title":"Oncotarget."},{"issue":"4849","key":"2021120916264119300_B28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.2451290","article-title":"Cell and environment interactions in tumor microregions: the multicell spheroid model","volume":"240","author":"Sutherland","year":"1988","journal-title":"Science."},{"key":"2021120916264119300_B29","doi-asserted-by":"crossref","first-page":"853703","DOI":"10.1155\/2012\/853703","article-title":"Integrins and their extracellular matrix ligands in lymphangiogenesis and lymph node metastasis","volume":"2012","author":"Chen","year":"2012","journal-title":"Int J Cell Biol."},{"issue":"1","key":"2021120916264119300_B30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2172-11-42","article-title":"Ultrastructural localization of extracellular matrix proteins of the lymph node cortex: evidence supporting the reticular network as a pathway for lymphocyte migration","volume":"11","author":"Sobocinski","year":"2010","journal-title":"BMC Immunol."},{"issue":"12","key":"2021120916264119300_B31","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/annonc\/mdy450","article-title":"Dissection of DLBCL microenvironment provides a gene expression-based predictor of survival applicable to formalin-fixed paraffin-embedded tissue","volume":"29","author":"Ciavarella","year":"2018","journal-title":"Ann Oncol."},{"issue":"8","key":"2021120916264119300_B32","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1038\/bcj.2013.32","article-title":"Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model","volume":"3","author":"Decaup","year":"2013","journal-title":"Blood Cancer J."},{"issue":"6","key":"2021120916264119300_B33","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nri3846","article-title":"Lymph node fibroblastic reticular cells in health and disease","volume":"15","author":"Fletcher","year":"2015","journal-title":"Nat Rev Immunol."},{"issue":"8","key":"2021120916264119300_B34","doi-asserted-by":"crossref","first-page":"e20200053","DOI":"10.1084\/jem.20200053","article-title":"Mechanosensing through YAP controls T cell activation and metabolism","volume":"217","author":"Meng","year":"2020","journal-title":"J Exp Med."},{"issue":"5","key":"2021120916264119300_B35","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1083\/jcb.201511053","article-title":"T cell activation requires force generation","volume":"213","author":"Hu","year":"2016","journal-title":"J Cell Biol."},{"issue":"2","key":"2021120916264119300_B36","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.celrep.2018.03.069","article-title":"How biophysical forces regulate human B cell lymphomas","volume":"23","author":"Apoorva","year":"2018","journal-title":"Cell Rep."},{"key":"2021120916264119300_B37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.coi.2016.12.002","article-title":"Murine models of germinal center derived-lymphomas","volume":"45","author":"Ramezani-Rad","year":"2017","journal-title":"Curr Opin Immunol."},{"issue":"3","key":"2021120916264119300_B38","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.jaci.2019.07.004","article-title":"B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease","volume":"145","author":"Della-Torre","year":"2020","journal-title":"J Allergy Clin Immunol."},{"issue":"3","key":"2021120916264119300_B39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1369\/jhc.2008.952200","article-title":"Altered expression of fibronectin and collagens I and IV in multiple myeloma and monoclonal gammopathy of undetermined significance","volume":"57","author":"Tancred","year":"2009","journal-title":"J Histochem Cytochem."},{"issue":"12","key":"2021120916264119300_B40","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1182\/blood-2004-10-3941","article-title":"Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma","volume":"105","author":"Mikaelsson","year":"2005","journal-title":"Blood."},{"issue":"3-4","key":"2021120916264119300_B41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11626-003-0010-3","article-title":"Matrix synthesis by bladder smooth muscle cells is modulated by stretch frequency","volume":"39","author":"Coplen","year":"2003","journal-title":"In\u00a0Vitro Cell Dev Biol Anim."},{"issue":"1","key":"2021120916264119300_B42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/03008200490278124","article-title":"Compression and tension: differential effects on matrix accumulation by periodontal ligament fibroblasts in\u00a0vitro","volume":"45","author":"He","year":"2004","journal-title":"Connect Tissue Res."},{"issue":"10","key":"2021120916264119300_B43","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1158\/1078-0432.CCR-13-2305","article-title":"COX-2-independent effects of celecoxib sensitize lymphoma B cells to TRAIL-mediated apoptosis","volume":"20","author":"Gallouet","year":"2014","journal-title":"Clin Cancer Res."},{"key":"2021120916264119300_B44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.biomaterials.2015.06.002","article-title":"Ex\u00a0vivo engineered immune organoids for controlled germinal center\u00a0reactions","volume":"63","author":"Purwada","year":"2015","journal-title":"Biomaterials."},{"key":"2021120916264119300_B45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jconrel.2018.12.010","article-title":"Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release","volume":"295","author":"Sabhachandani","year":"2019","journal-title":"J Control Release."},{"issue":"2-3","key":"2021120916264119300_B46","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1040-8428(00)00086-X","article-title":"Multicellular resistance: a paradigm for clinical resistance?","volume":"36","author":"Desoize","year":"2000","journal-title":"Crit Rev Oncol Hematol."},{"issue":"8","key":"2021120916264119300_B47","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrc1893","article-title":"Drug penetration in solid tumours","volume":"6","author":"Minchinton","year":"2006","journal-title":"Nat Rev Cancer."},{"issue":"23","key":"2021120916264119300_B48","first-page":"2628","article-title":"Venetoclax-rituximab with or without bendamustine vs bendamustine-rituximab in relapsed\/refractory follicular lymphoma","volume":"136","author":"Zinzani","year":"2020","journal-title":"Blood."},{"issue":"5","key":"2021120916264119300_B49","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1182\/blood.2020006578","article-title":"A phase 2 study of venetoclax plus R-CHOP as first-line treatment for patients with diffuse large B-cell lymphoma [published correction appears in Blood. 2021;137(13):1844]","volume":"137","author":"Morschhauser","year":"2021","journal-title":"Blood."},{"key":"2021120916264119300_B50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1182\/blood-2020-136219","article-title":"Ibrutinib and venetoclax in relapsed and refractory follicular lymphoma","volume":"136","author":"Ujjani","year":"2020","journal-title":"Blood."},{"issue":"5","key":"2021120916264119300_B51","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1182\/blood-2006-11-060350","article-title":"Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas","volume":"110","author":"Lwin","year":"2007","journal-title":"Blood."},{"issue":"7","key":"2021120916264119300_B52","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/sj.leu.2404723","article-title":"Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB\/p52) in non-Hodgkin\u2019s lymphoma cells","volume":"21","author":"Lwin","year":"2007","journal-title":"Leukemia."},{"issue":"8","key":"2021120916264119300_B53","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3324\/haematol.2011.040659","article-title":"Mesenchymal stromal cells protect mantle cell lymphoma cells from spontaneous and drug-induced apoptosis through secretion of B-cell activating factor and activation of the canonical and non-canonical nuclear factor \u03baB pathways","volume":"97","author":"Medina","year":"2012","journal-title":"Haematologica."},{"issue":"10","key":"2021120916264119300_B54","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.3390\/cancers12102865","article-title":"Integrative analysis of cell crosstalk within follicular lymphoma cell niche: towards a definition of the FL supportive synapse","volume":"12","author":"Pangault","year":"2020","journal-title":"Cancers (Basel)."},{"issue":"1","key":"2021120916264119300_B55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1182\/blood.2020008791","article-title":"Extracellular vesicles shed by follicular lymphoma B cells promote polarization of the bone marrow stromal cell niche","volume":"138","author":"Dumontet","year":"2021","journal-title":"Blood."},{"issue":"12","key":"2021120916264119300_B56","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1038\/sj.leu.2403485","article-title":"TGFbeta-mediated activation of Smad1 in B-cell non-Hodgkin\u2019s lymphoma and effect on cell proliferation","volume":"18","author":"Munoz","year":"2004","journal-title":"Leukemia."}],"container-title":["Blood Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article-pdf\/5\/23\/5372\/1850243\/advancesadv2020003949.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article-pdf\/5\/23\/5372\/1850243\/advancesadv2020003949.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T11:33:15Z","timestamp":1639049595000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article\/5\/23\/5372\/477016\/A-novel-3D-culture-model-recapitulates-primary-FL"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,9]]},"references-count":56,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2021,12,14]]}},"URL":"https:\/\/doi.org\/10.1182\/bloodadvances.2020003949","relation":{},"ISSN":["2473-9529","2473-9537"],"issn-type":[{"value":"2473-9529","type":"print"},{"value":"2473-9537","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,9]]}}}