{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:30:20Z","timestamp":1775277020076,"version":"3.50.1"},"reference-count":181,"publisher":"American Society of Hematology","issue":"11","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T helper 17 (Th17) cells have a prominent role in autoimmune diseases. In contrast, the nature of these cells in cancer is controversial, with either pro- or antitumorigenic activities depending on various cancer settings. Chronic lymphocytic leukemia (CLL), a B-cell malignancy, is characterized by an imbalance in T-cell immune responses that contributes to disease progression and increased mortality. Many clinical reports indicate an increase in Th17 cells and\/or interleukin 17 serum cytokine levels in patients with CLL compared with healthy individuals, which correlates with various prognostic markers and significant changes in the tumor microenvironment. The exact mechanisms by which Th17 cells might contribute to CLL progression remain poorly investigated. In this review, we provide an updated presentation of the clinical information related to the significance of Th17 cells in CLL and their interaction with the complex leukemic microenvironment, including various mediators, immune cells, and nonimmune cells. We also address the available data regarding the effects of CLL-targeted therapies on Th17 cells and the potential of using these cells in adoptive cell therapies. Having a sound understanding of the role played by Th17 cells in CLL is crucial for designing novel therapies that can achieve immune homeostasis and maximize clinical benefits.<\/jats:p>","DOI":"10.1182\/bloodadvances.2022008985","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T16:56:16Z","timestamp":1672160176000},"page":"2401-2417","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":16,"title":["The role of Th17 cells in chronic lymphocytic leukemia: friend or\u00a0foe?"],"prefix":"10.1182","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-2601","authenticated-orcid":false,"given":"Wael","family":"Gamal","sequence":"first","affiliation":[{"name":"1Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL"},{"name":"2Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-2275","authenticated-orcid":false,"given":"Eva","family":"Sahakian","sequence":"additional","affiliation":[{"name":"1Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL"},{"name":"3Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Pinilla-Ibarz","sequence":"additional","affiliation":[{"name":"1Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL"},{"name":"3Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"issue":"12","key":"2023061218532922100_bib1","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/ajh.26367","article-title":"Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures","volume":"96","author":"Hallek","year":"2021","journal-title":"Am J Hematol"},{"issue":"1","key":"2023061218532922100_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"2023061218532922100_bib3","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1182\/blood-2012-02-362624","article-title":"The B-cell receptor signaling pathway as a therapeutic target in CLL","volume":"120","author":"Woyach","year":"2012","journal-title":"Blood"},{"key":"2023061218532922100_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-4614-8051-8_2","article-title":"The CLL cell microenvironment","volume":"792","author":"Burger","year":"2013","journal-title":"Advances in Chronic Lymphocytic Leukemia"},{"issue":"10","key":"2023061218532922100_bib5","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.1182\/blood-2007-08-108605","article-title":"CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment","volume":"111","author":"Patten","year":"2008","journal-title":"Blood"},{"issue":"19","key":"2023061218532922100_bib6","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1158\/1078-0432.CCR-06-1204","article-title":"Magnitude of stromal hemangiogenesis correlates with histologic subtype of non\u2013Hodgkin's lymphoma","volume":"12","author":"Ruan","year":"2006","journal-title":"Clin Cancer Res"},{"issue":"3","key":"2023061218532922100_bib7","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1182\/blood.V99.3.1030","article-title":"Distinctive features of \u201cnurselike\u201d cells that differentiate in the context of chronic lymphocytic leukemia","volume":"99","author":"Tsukada","year":"2002","journal-title":"Blood"},{"issue":"5","key":"2023061218532922100_bib8","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3390\/ijms21051825","article-title":"Immune response dysfunction in chronic lymphocytic leukemia: dissecting molecular mechanisms and microenvironmental conditions","volume":"21","author":"Arruga","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"9","key":"2023061218532922100_bib9","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1182\/blood-2012-09-457531","article-title":"T\u00a0cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production","volume":"121","author":"Riches","year":"2013","journal-title":"Blood"},{"issue":"3","key":"2023061218532922100_bib10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1053\/j.seminhematol.2014.05.006","article-title":"Immunomodulation and immune reconstitution in chronic lymphocytic leukemia","volume":"51","author":"Riches","year":"2014","journal-title":"Semin Hematol"},{"issue":"2","key":"2023061218532922100_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.hoc.2013.01.003","article-title":"Understanding the immunodeficiency in chronic lymphocytic leukemia: potential clinical implications","volume":"27","author":"Riches","year":"2013","journal-title":"Hematol\/Oncol Clin"},{"issue":"1","key":"2023061218532922100_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.celrep.2016.02.084","article-title":"Human cytotoxic T lymphocytes form dysfunctional immune synapses with B cells characterized by non-polarized lytic granule release","volume":"15","author":"Kabanova","year":"2016","journal-title":"Cell Rep"},{"issue":"7","key":"2023061218532922100_bib13","first-page":"2427","article-title":"Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug","volume":"118","author":"Ramsay","year":"2008","journal-title":"J\u00a0Clin Invest"},{"issue":"15","key":"2023061218532922100_bib14","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1073\/pnas.0901166106","article-title":"E\u03bc-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction","volume":"106","author":"Gorgun","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"2023061218532922100_bib15","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1200\/JCO.2012.43.4449","article-title":"Overall and cancer-specific survival of patients with breast, colon, kidney, and lung cancers with and without chronic lymphocytic leukemia: a SEER population-based study","volume":"31","author":"Solomon","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"issue":"6","key":"2023061218532922100_bib16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.blre.2018.04.007","article-title":"Infections in patients with chronic lymphocytic leukaemia: mitigating risk in the era of targeted therapies","volume":"32","author":"Teh","year":"2018","journal-title":"Blood Rev"},{"issue":"3","key":"2023061218532922100_bib17","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41375-018-0250-6","article-title":"Control of chronic lymphocytic leukemia development by clonally-expanded CD8+ T-cells that undergo functional exhaustion in secondary lymphoid tissues","volume":"33","author":"Hanna","year":"2019","journal-title":"Leukemia"},{"issue":"1","key":"2023061218532922100_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1182\/blood.V100.1.167","article-title":"T-cell responses against chronic lymphocytic leukemia cells: implications for immunotherapy","volume":"100","author":"Krackhardt","year":"2002","journal-title":"Blood"},{"issue":"11","key":"2023061218532922100_bib19","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1038\/s41375-021-01198-1","article-title":"EOMES is essential for antitumor activity of CD8+ T cells in chronic lymphocytic leukemia","volume":"35","author":"Lla\u00f3-Cid","year":"2021","journal-title":"Leukemia"},{"issue":"2","key":"2023061218532922100_bib20","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1182\/blood-2015-02-626754","article-title":"Mechanisms of PD-L1\/PD-1\u2013mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the E\u03bc-TCL1 CLL mouse model","volume":"126","author":"McClanahan","year":"2015","journal-title":"Blood"},{"issue":"11","key":"2023061218532922100_bib21","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1038\/s41375-021-01217-1","article-title":"Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia","volume":"35","author":"Rivas","year":"2021","journal-title":"Leukemia"},{"issue":"7","key":"2023061218532922100_bib22","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/leu.2016.362","article-title":"Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements","volume":"31","author":"Vardi","year":"2017","journal-title":"Leukemia"},{"key":"2023061218532922100_bib23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4 T cell populations","volume":"28","author":"Zhu","year":"2010","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"2023061218532922100_bib24","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/sj.leu.2405015","article-title":"Tumor-derived IL-6 may contribute to the immunological defect in CLL","volume":"22","author":"Buggins","year":"2008","journal-title":"Leukemia"},{"issue":"7","key":"2023061218532922100_bib25","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1172\/JCI24176","article-title":"Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8\u00a0T cells","volume":"115","author":"G\u00f6rg\u00fcn","year":"2005","journal-title":"J\u00a0Clin Invest"},{"issue":"7","key":"2023061218532922100_bib26","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0145-2126(01)00194-1","article-title":"T\u00a0type 1\/type 2 subsets balance in B-cell chronic lymphocytic leukemia--the three-color flow cytometry analysis","volume":"26","author":"Podhorecka","year":"2002","journal-title":"Leuk Res"},{"issue":"5","key":"2023061218532922100_bib27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1034\/j.1600-0609.2002.01612.x","article-title":"Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B-CLL)","volume":"68","author":"Rossmann","year":"2002","journal-title":"Eur J Haematol"},{"issue":"3","key":"2023061218532922100_bib28","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.celrep.2013.07.011","article-title":"Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells","volume":"4","author":"Os","year":"2013","journal-title":"Cell Rep"},{"issue":"1","key":"2023061218532922100_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/bjh.16316","article-title":"TBET-expressing Th1 CD4+ T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in E\u03bc-TCL1 mice","volume":"189","author":"Roessner","year":"2020","journal-title":"Br J Haematol"},{"issue":"2","key":"2023061218532922100_bib30","doi-asserted-by":"crossref","first-page":"827","DOI":"10.4049\/jimmunol.1401350","article-title":"Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell\u2013derived IFN-\u03b3 by a T-bet\u2013dependent mechanism","volume":"194","author":"B\u00fcrgler","year":"2015","journal-title":"J\u00a0Immunol"},{"issue":"7","key":"2023061218532922100_bib31","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0145-2126(00)00022-9","article-title":"Disruption of the IFN-\u03b3 cytokine network in chronic lymphocytic leukemia contributes to resistance of leukemic B cells to apoptosis","volume":"24","author":"Zaki","year":"2000","journal-title":"Leuk Res"},{"issue":"3","key":"2023061218532922100_bib32","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/bjh.12401","article-title":"Enhancement of CD 154\/IL 4 proliferation by the T follicular helper (T fh) cytokine, IL 21 and increased numbers of circulating cells resembling T fh cells in chronic lymphocytic leukaemia","volume":"162","author":"Ahearne","year":"2013","journal-title":"Br J Haematol"},{"issue":"6","key":"2023061218532922100_bib33","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1007\/s13277-013-0937-2","article-title":"Association of peripheral CD4+ CXCR5+ T cells with chronic lymphocytic leukemia","volume":"34","author":"Cha","year":"2013","journal-title":"Tumor Biol"},{"issue":"17","key":"2023061218532922100_bib34","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1182\/bloodadvances.2019000360","article-title":"Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment","volume":"3","author":"de Weerdt","year":"2019","journal-title":"Blood Adv"},{"issue":"17","key":"2023061218532922100_bib35","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1182\/blood-2012-11-467670","article-title":"IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells","volume":"122","author":"Pascutti","year":"2013","journal-title":"Blood"},{"issue":"5","key":"2023061218532922100_bib36","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/s41375-022-01519-y","article-title":"Activation and expansion of T-follicular helper cells in chronic lymphocytic leukemia nurselike cell co-cultures","volume":"36","author":"Vaca","year":"2022","journal-title":"Leukemia"},{"issue":"8","key":"2023061218532922100_bib37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/intimm\/dxw025","article-title":"Roles of regulatory T cells in cancer immunity","volume":"28","author":"Takeuchi","year":"2016","journal-title":"Int Immunol"},{"issue":"5","key":"2023061218532922100_bib38","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3109\/10428194.2012.728287","article-title":"Regulatory T-cells in B-cell chronic lymphocytic leukemia: their role in disease progression and autoimmune cytopenias","volume":"54","author":"Lad","year":"2013","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"2023061218532922100_bib39","doi-asserted-by":"crossref","first-page":"e1371399","DOI":"10.1080\/2162402X.2017.1371399","article-title":"TIGIT expressing CD4+ T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia","volume":"7","author":"Catakovic","year":"2018","journal-title":"OncoImmunology"},{"issue":"1","key":"2023061218532922100_bib40","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/sj.leu.2404869","article-title":"The high frequency of T regulatory cells in patients with B-cell chronic lymphocytic leukemia is diminished through treatment with thalidomide","volume":"22","author":"Giannopoulos","year":"2008","journal-title":"Leukemia"},{"issue":"6","key":"2023061218532922100_bib41","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1182\/blood-2005-02-0642","article-title":"Reduced frequencies and suppressive function of CD4+ CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine","volume":"106","author":"Beyer","year":"2005","journal-title":"Blood"},{"issue":"2","key":"2023061218532922100_bib42","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/modpathol.2011.164","article-title":"Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia","volume":"25","author":"Biancotto","year":"2012","journal-title":"Mod Pathol"},{"issue":"3","key":"2023061218532922100_bib43","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.leukres.2010.08.010","article-title":"Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease","volume":"35","author":"D\u2019Arena","year":"2011","journal-title":"Leuk Res"},{"issue":"10","key":"2023061218532922100_bib44","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1002\/cncr.25752","article-title":"Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia","volume":"117","author":"Weiss","year":"2011","journal-title":"Cancer"},{"issue":"1","key":"2023061218532922100_bib45","first-page":"52","article-title":"Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander?","volume":"3","author":"D\u2019Arena","year":"2013","journal-title":"Am J Blood Res"},{"issue":"2","key":"2023061218532922100_bib46","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2249.2011.04466.x","article-title":"Chronic lymphocytic leukaemia cells drive the global CD4+ T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4+ forkhead box P3+ T cells","volume":"166","author":"Piper","year":"2011","journal-title":"Clin Exp Immunol"},{"issue":"14","key":"2023061218532922100_bib47","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1182\/blood-2017-06-792267","article-title":"Dual PD1\/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia","volume":"131","author":"Wierz","year":"2018","journal-title":"Blood"},{"issue":"8","key":"2023061218532922100_bib48","doi-asserted-by":"crossref","first-page":"e1465167","DOI":"10.1080\/2162402X.2018.1465167","article-title":"High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia","volume":"7","author":"Wierz","year":"2018","journal-title":"OncoImmunology"},{"issue":"10","key":"2023061218532922100_bib49","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1038\/sj.leu.2403907","article-title":"Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia","volume":"19","author":"Motta","year":"2005","journal-title":"Leukemia"},{"issue":"6","key":"2023061218532922100_bib50","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/s41375-018-0318-3","article-title":"PI3K\u03b4 inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia","volume":"33","author":"Hanna","year":"2019","journal-title":"Leukemia"},{"issue":"1","key":"2023061218532922100_bib51","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12967-018-1545-0","article-title":"Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients","volume":"16","author":"De Matteis","year":"2018","journal-title":"J Transl Med"},{"issue":"11","key":"2023061218532922100_bib52","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17\u2013producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat Immunol"},{"issue":"11","key":"2023061218532922100_bib53","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A\u00a0distinct lineage of CD4\u00a0T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat Immunol"},{"issue":"2","key":"2023061218532922100_bib54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nm1551","article-title":"A\u00a0brief history of TH17, the first major revision in the TH1\/TH2 hypothesis of T cell\u2013mediated tissue damage","volume":"13","author":"Steinman","year":"2007","journal-title":"Nat Med"},{"issue":"1","key":"2023061218532922100_bib55","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-065X.2008.00628.x","article-title":"Th17 cells in human disease","volume":"223","author":"Tesmer","year":"2008","journal-title":"Immunol Rev"},{"issue":"4","key":"2023061218532922100_bib56","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.immuni.2008.03.004","article-title":"The biological functions of T helper 17 cell effector cytokines in inflammation","volume":"28","author":"Ouyang","year":"2008","journal-title":"Immunity"},{"issue":"10","key":"2023061218532922100_bib57","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"Liang","year":"2006","journal-title":"J\u00a0Exp Med"},{"issue":"5","key":"2023061218532922100_bib58","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nri2295","article-title":"TH17 cells in development: an updated view of their molecular identity and genetic programming","volume":"8","author":"Dong","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"2023061218532922100_bib59","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1084\/jem.20060285","article-title":"A\u00a0crucial role for interleukin (IL)-1 in the induction of IL-17\u2013producing T cells that mediate autoimmune encephalomyelitis","volume":"203","author":"Sutton","year":"2006","journal-title":"J\u00a0Exp Med"},{"issue":"1","key":"2023061218532922100_bib60","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4049\/jimmunol.177.1.566","article-title":"IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis","volume":"177","author":"Komiyama","year":"2006","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"2023061218532922100_bib61","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.immuni.2016.10.020","article-title":"Autoimmune renal disease is exacerbated by S1P-receptor-1-dependent intestinal Th17 cell migration to the kidney","volume":"45","author":"Krebs","year":"2016","journal-title":"Immunity"},{"issue":"3","key":"2023061218532922100_bib62","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.immuni.2016.02.007","article-title":"Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation","volume":"44","author":"Kumar","year":"2016","journal-title":"Immunity"},{"issue":"6","key":"2023061218532922100_bib63","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.immuni.2010.06.001","article-title":"Ivanov II, Darce J, et\u00a0al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells","volume":"32","author":"Wu","year":"2010","journal-title":"Immunity"},{"issue":"5","key":"2023061218532922100_bib64","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jhep.2008.12.033","article-title":"Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients","volume":"50","author":"Zhang","year":"2009","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"2023061218532922100_bib65","doi-asserted-by":"crossref","first-page":"36551","DOI":"10.1038\/srep36551","article-title":"IL-17 promotes angiogenic factors IL-6, IL-8, and Vegf production via Stat1 in lung adenocarcinoma","volume":"6","author":"Huang","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"2023061218532922100_bib66","first-page":"1169","article-title":"Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-\u03baB\/ZEB1 signal pathway","volume":"5","author":"Gu","year":"2015","journal-title":"Am J Cancer Res"},{"issue":"3","key":"2023061218532922100_bib67","doi-asserted-by":"crossref","first-page":"e18219","DOI":"10.1371\/journal.pone.0018219","article-title":"The accumulation and prognosis value of tumor infiltrating IL-17 producing cells in esophageal squamous cell carcinoma","volume":"6","author":"Lv","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"2023061218532922100_bib68","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s12094-014-1197-3","article-title":"Interleukin-17 is a favorable prognostic marker for colorectal cancer","volume":"17","author":"Lin","year":"2015","journal-title":"Clin Transl Oncol"},{"issue":"6","key":"2023061218532922100_bib69","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00262-015-1678-4","article-title":"FoxP3+ and IL-17+ cells are correlated with improved prognosis in cervical adenocarcinoma","volume":"64","author":"Punt","year":"2015","journal-title":"Cancer Immunol Immunother"},{"issue":"5","key":"2023061218532922100_bib70","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41423-018-0004-4","article-title":"When worlds collide: Th17 and Treg cells in cancer and autoimmunity","volume":"15","author":"Knochelmann","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"2023061218532922100_bib71","doi-asserted-by":"crossref","first-page":"314620","DOI":"10.1155\/2015\/314620","article-title":"Th17 cell plasticity and functions in cancer immunity","volume":"2015","author":"Gu\u00e9ry","year":"2015","journal-title":"BioMed Res Int"},{"issue":"12","key":"2023061218532922100_bib72","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.molmed.2012.09.007","article-title":"Controversies on the role of Th17 in cancer: a TGF-\u03b2-dependent immunosuppressive activity?","volume":"18","author":"Martin","year":"2012","journal-title":"Trends Mol Med"},{"issue":"11","key":"2023061218532922100_bib73","doi-asserted-by":"crossref","first-page":"e78091","DOI":"10.1371\/journal.pone.0078091","article-title":"Th17\/IL-17A might play a protective role in chronic lymphocytic leukemia immunity","volume":"8","author":"Hus","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"2023061218532922100_bib74","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s13277-012-0628-4","article-title":"Downregulation of IL-17-producing T cells is associated with regulatory T cell expansion and disease progression in chronic lymphocytic leukemia","volume":"34","author":"Jadidi-Niaragh","year":"2013","journal-title":"Tumor Biol"},{"issue":"25","key":"2023061218532922100_bib75","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1182\/blood.2021010944","article-title":"Autoimmune cytopenia and CLL ride together","volume":"137","author":"Moreno","year":"2021","journal-title":"Blood"},{"issue":"5","key":"2023061218532922100_bib76","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/mi.2009.100","article-title":"Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa","volume":"2","author":"Khader","year":"2009","journal-title":"Mucosal Immunol"},{"issue":"6","key":"2023061218532922100_bib77","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor ROR\u03b3t directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"issue":"13","key":"2023061218532922100_bib78","doi-asserted-by":"crossref","first-page":"9358","DOI":"10.1074\/jbc.C600321200","article-title":"STAT3 regulates cytokine-mediated generation of inflammatory helper T cells","volume":"282","author":"Yang","year":"2007","journal-title":"J\u00a0Biol Chem"},{"issue":"9","key":"2023061218532922100_bib79","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ni1500","article-title":"The development of inflammatory TH-17 cells requires interferon-regulatory factor 4","volume":"8","author":"Br\u00fcstle","year":"2007","journal-title":"Nat Immunol"},{"issue":"7191","key":"2023061218532922100_bib80","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature06880","article-title":"Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor","volume":"453","author":"Quintana","year":"2008","journal-title":"Nature"},{"issue":"55","key":"2023061218532922100_bib81","doi-asserted-by":"crossref","first-page":"55ra78","DOI":"10.1126\/scitranslmed.3000448","article-title":"The inducible costimulator (ICOS) is critical for the development of human TH17 cells","volume":"2","author":"Paulos","year":"2010","journal-title":"Sci Transl Med"},{"key":"2023061218532922100_bib82","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"2023061218532922100_bib83","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.4049\/jimmunol.181.9.5948","article-title":"IL-23 promotes maintenance but not commitment to the Th17 lineage","volume":"181","author":"Stritesky","year":"2008","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"2023061218532922100_bib84","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2008.11.005","article-title":"Late developmental plasticity in the T helper 17 lineage","volume":"30","author":"Lee","year":"2009","journal-title":"Immunity"},{"issue":"12","key":"2023061218532922100_bib85","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1002\/eji.201242648","article-title":"Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells","volume":"42","author":"Maggi","year":"2012","journal-title":"Eur J Immunol"},{"issue":"6","key":"2023061218532922100_bib86","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1182\/blood-2009-03-208249","article-title":"Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments","volume":"114","author":"Kryczek","year":"2009","journal-title":"Blood"},{"issue":"5","key":"2023061218532922100_bib87","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1158\/0008-5472.CAN-11-3432","article-title":"Human TH17 immune cells specific for the tumor antigen MAGE-A3 convert to IFN-\u03b3\u2013secreting cells as they differentiate into effector T cells in\u00a0vivo","volume":"72","author":"Hama\u00ef","year":"2012","journal-title":"Cancer Res"},{"issue":"2","key":"2023061218532922100_bib88","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1182\/blood-2007-11-120998","article-title":"Tumor-specific Th17-polarized cells eradicate large established melanoma","volume":"112","author":"Muranski","year":"2008","journal-title":"Blood"},{"issue":"6","key":"2023061218532922100_bib89","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.immuni.2011.09.019","article-title":"Th17 cells are long lived and retain a stem cell-like molecular signature","volume":"35","author":"Muranski","year":"2011","journal-title":"Immunity"},{"issue":"104","key":"2023061218532922100_bib90","doi-asserted-by":"crossref","first-page":"104ra100","DOI":"10.1126\/scitranslmed.3002949","article-title":"Human TH17 cells are long-lived effector memory cells","volume":"3","author":"Kryczek","year":"2011","journal-title":"Sci Transl Med"},{"issue":"5","key":"2023061218532922100_bib91","doi-asserted-by":"crossref","first-page":"e90772","DOI":"10.1172\/jci.insight.90772","article-title":"Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion","volume":"2","author":"Bowers","year":"2017","journal-title":"JCI insight"},{"issue":"10","key":"2023061218532922100_bib92","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.4049\/jimmunol.1401776","article-title":"Conversion of Th17 into IL-17A(neg) regulatory T cells: a novel mechanism in prolonged allograft survival promoted by mesenchymal stem cell\u2013supported minimized immunosuppressive therapy","volume":"193","author":"Obermajer","year":"2014","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"2023061218532922100_bib93","doi-asserted-by":"crossref","first-page":"14649","DOI":"10.1038\/ncomms14649","article-title":"Suppressive IL-17A+ Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells","volume":"8","author":"Downs-Canner","year":"2017","journal-title":"Nat Commun"},{"issue":"4","key":"2023061218532922100_bib94","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/eji.201040682","article-title":"Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-\u03b3+ and FOXP3+ T cells with potent suppressive function","volume":"41","author":"Ye","year":"2011","journal-title":"Eur J Immunol"},{"key":"2023061218532922100_bib95","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.intimp.2016.07.008","article-title":"Increased IL-10\/IL-17 ratio is aggravated along with the prognosis of patients with chronic lymphocytic leukemia","volume":"40","author":"Pang","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"2023061218532922100_bib96","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.leukres.2018.01.006","article-title":"Targeting the IL-17\/IL-6 axis can alter growth of chronic lymphocytic leukemia in\u00a0vivo\/in\u00a0vitro","volume":"66","author":"Zhu","year":"2018","journal-title":"Leuk Res"},{"issue":"19","key":"2023061218532922100_bib97","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1182\/blood-2011-03-342436","article-title":"Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia","volume":"118","author":"Yan","year":"2011","journal-title":"Blood"},{"issue":"1","key":"2023061218532922100_bib98","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/cyto.b.21487","article-title":"Elevated IL-17A and IL-22 regulate expression of inducible CD38 and Zap-70 in chronic lymphocytic leukemia","volume":"94","author":"Kouzegaran","year":"2018","journal-title":"Cytometry B Clin Cytometry"},{"issue":"5","key":"2023061218532922100_bib99","first-page":"1128","article-title":"Increased frequencies of Th17 in the peripheral blood of patients with chronic lymphocytic leukemia: A one year follow-up","volume":"30","author":"Tang","year":"2014","journal-title":"Pakistan J Med Sci"},{"issue":"4","key":"2023061218532922100_bib100","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3324\/haematol.2011.047316","article-title":"Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance","volume":"97","author":"Jain","year":"2012","journal-title":"Haematologica"},{"issue":"8","key":"2023061218532922100_bib101","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.3109\/10428194.2014.986479","article-title":"Regulatory T-cell and T-helper 17 balance in chronic lymphocytic leukemia progression and autoimmune cytopenias","volume":"56","author":"Lad","year":"2015","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"2023061218532922100_bib102","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s10753-011-9419-0","article-title":"A\u00a0distinct regulatory role of Th17 cytokines IL-17A and IL-17F in chemokine secretion from lung microvascular endothelial cells","volume":"35","author":"Fujie","year":"2012","journal-title":"Inflammation"},{"issue":"1","key":"2023061218532922100_bib103","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","article-title":"Differential roles of interleukin-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses","volume":"30","author":"Ishigame","year":"2009","journal-title":"Immunity"},{"issue":"2","key":"2023061218532922100_bib104","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood-2010-05-284984","article-title":"The lymph node microenvironment promotes B-cell receptor signaling, NF-\u03baB activation, and tumor proliferation in chronic lymphocytic leukemia","volume":"117","author":"Herishanu","year":"2011","journal-title":"Blood"},{"issue":"2","key":"2023061218532922100_bib105","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood.V46.2.219.219","article-title":"Clinical staging of chronic lymphocytic leukemia","volume":"46","author":"Rai","year":"1975","journal-title":"Blood"},{"issue":"12","key":"2023061218532922100_bib106","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1182\/blood-2007-06-094029","article-title":"CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential","volume":"110","author":"Deaglio","year":"2007","journal-title":"Blood"},{"issue":"12","key":"2023061218532922100_bib107","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1038\/sj.leu.2403975","article-title":"CD38 expression levels in chronic lymphocytic leukemia B cells are associated with activation marker expression and differential responses to interferon stimulation","volume":"19","author":"Pittner","year":"2005","journal-title":"Leukemia"},{"issue":"18","key":"2023061218532922100_bib108","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJMoa023143","article-title":"ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia","volume":"348","author":"Crespo","year":"2003","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"2023061218532922100_bib109","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1182\/blood-2005-12-4986","article-title":"Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia","volume":"108","author":"Del Principe","year":"2006","journal-title":"Blood"},{"issue":"10","key":"2023061218532922100_bib110","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1182\/bloodadvances.2019001091","article-title":"Targeting CD38 is lethal to Breg-like chronic lymphocytic leukemia cells and Tregs, but restores CD8+ T-cell responses","volume":"4","author":"Manna","year":"2020","journal-title":"Blood Adv"},{"issue":"7","key":"2023061218532922100_bib111","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1001\/jamaoncol.2015.0779","article-title":"Predicting prognosis in chronic lymphocytic leukemia in the contemporary era","volume":"1","author":"Nabhan","year":"2015","journal-title":"JAMA Oncol"},{"issue":"6","key":"2023061218532922100_bib112","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3324\/haematol.2012.077537","article-title":"The PD-1\/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia","volume":"98","author":"Brusa","year":"2013","journal-title":"Haematologica"},{"issue":"5","key":"2023061218532922100_bib113","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3324\/haematol.2016.148965","article-title":"Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia","volume":"102","author":"Shapiro","year":"2017","journal-title":"Haematologica"},{"issue":"7","key":"2023061218532922100_bib114","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1182\/blood-2012-02-411678","article-title":"Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer","volume":"120","author":"Ramsay","year":"2012","journal-title":"Blood"},{"issue":"8","key":"2023061218532922100_bib115","first-page":"2269","article-title":"Upregulation of Galectin-9 and PD-L1 immune checkpoints molecules in patients with chronic lymphocytic leukemia","volume":"18","author":"Taghiloo","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"key":"2023061218532922100_bib116","doi-asserted-by":"crossref","first-page":"594556","DOI":"10.3389\/fimmu.2020.594556","article-title":"Immune dysfunctions and immune-based therapeutic interventions in chronic lymphocytic leukemia","volume":"11","author":"Griggio","year":"2020","journal-title":"Front Immunol"},{"key":"2023061218532922100_bib117","doi-asserted-by":"crossref","first-page":"612244","DOI":"10.3389\/fimmu.2020.612244","article-title":"T\u00a0cells in chronic lymphocytic leukemia: a two-edged sword","volume":"11","author":"Vlachonikola","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"2023061218532922100_bib118","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1158\/1078-0432.CCR-14-3017","article-title":"Antigen selection shapes the T-cell repertoire in chronic lymphocytic leukemiaimmunogenetic analysis of the T-cell repertoire in CLL","volume":"22","author":"Vardi","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"1","key":"2023061218532922100_bib119","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1182\/blood.2018885863","article-title":"Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy","volume":"134","author":"van Bruggen","year":"2019","journal-title":"Blood"},{"issue":"1","key":"2023061218532922100_bib120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1182\/bloodadvances.2016000984","article-title":"Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment","volume":"1","author":"Serra","year":"2016","journal-title":"Blood Adv"},{"issue":"5","key":"2023061218532922100_bib121","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1182\/blood-2013-12-546416","article-title":"CLL-cells induce IDOhi CD14+ HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs","volume":"124","author":"Jitschin","year":"2014","journal-title":"Blood"},{"issue":"15","key":"2023061218532922100_bib122","first-page":"4497","article-title":"The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response","volume":"63","author":"Orsini","year":"2003","journal-title":"Cancer Res"},{"issue":"29","key":"2023061218532922100_bib123","doi-asserted-by":"crossref","first-page":"46301","DOI":"10.18632\/oncotarget.10093","article-title":"Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia","volume":"7","author":"Toniolo","year":"2016","journal-title":"Oncotarget"},{"issue":"4","key":"2023061218532922100_bib124","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood-2015-11-682377","article-title":"Extracellular vesicles released by CD40\/IL-4\u2013stimulated CLL cells confer altered functional properties to CD4+ T cells","volume":"128","author":"Smallwood","year":"2016","journal-title":"Blood"},{"issue":"1","key":"2023061218532922100_bib125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1158\/2643-3230.BCD-22-0029","article-title":"Extracellular vesicle secretion by leukemia cells in vivo promotes CLL progression by hampering antitumor T-cell responses","volume":"4","author":"Gargiulo","year":"2023","journal-title":"Blood Cancer Discov"},{"issue":"1","key":"2023061218532922100_bib126","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1182\/blood.V97.1.256","article-title":"Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome","volume":"97","author":"Fayad","year":"2001","journal-title":"Blood"},{"issue":"3","key":"2023061218532922100_bib127","first-page":"422","article-title":"Expression of interleukin-1 alpha, interleukin-1 beta and interleukin-6 in chronic B lymphocytic leukaemia (B-CLL) cells from patients at different stages of disease progression","volume":"84","author":"Aguilar-Santelises","year":"1991","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"2023061218532922100_bib128","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1182\/blood.V84.1.220.220","article-title":"Cytokine gene expression in B-cell chronic lymphocytic leukemia: evidence of constitutive interleukin-8 (IL-8) mRNA expression and secretion of biologically active IL-8 protein","volume":"84","author":"Di Celle","year":"1994","journal-title":"Blood"},{"issue":"10","key":"2023061218532922100_bib129","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0145-2126(89)90048-9","article-title":"Low IL-1 beta production in leukemic cells from progressive B cell chronic leukemia (B-CLL)","volume":"13","author":"Aguilar-Santelises","year":"1989","journal-title":"Leuk Res"},{"issue":"6","key":"2023061218532922100_bib130","first-page":"600","article-title":"Interleukin-1 beta, interleukin-1 receptor antagonist and interleukin-6 plasma levels and cytokine gene polymorphisms in chronic lymphocytic leukemia: correlation with prognostic parameters","volume":"85","author":"Hulkkonen","year":"2000","journal-title":"Haematologica"},{"issue":"12","key":"2023061218532922100_bib131","doi-asserted-by":"crossref","first-page":"e158243","DOI":"10.1172\/jci.insight.158243","article-title":"Activated CLL cells regulate IL17F producing Th17 cells in miR155 dependent and outcome specific manners","volume":"7","author":"Jung","year":"2022","journal-title":"JCI insight"},{"issue":"1","key":"2023061218532922100_bib132","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12026-015-8722-5","article-title":"Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes","volume":"63","author":"Sherry","year":"2015","journal-title":"Immunol Res"},{"key":"2023061218532922100_bib133","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fimmu.2012.00281","article-title":"Induction of Th17 cell differentiation by B-1 cells","volume":"3","author":"Wang","year":"2012","journal-title":"Front Immunol"},{"issue":"12","key":"2023061218532922100_bib134","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1084\/jem.20120833","article-title":"Cellular origin and pathophysiology of chronic lymphocytic leukemia","volume":"209","author":"Seifert","year":"2012","journal-title":"J\u00a0Exp Med"},{"issue":"23","key":"2023061218532922100_bib135","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1182\/blood-2011-05-352682","article-title":"CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation","volume":"118","author":"De Wit","year":"2011","journal-title":"Blood"},{"issue":"10","key":"2023061218532922100_bib136","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.4049\/jimmunol.0903823","article-title":"A\u00a0ligand for CD5 is CD5","volume":"185","author":"Brown","year":"2010","journal-title":"J\u00a0Immunol"},{"issue":"4","key":"2023061218532922100_bib137","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/eji.201343998","article-title":"CD5 enhances Th17-cell differentiation by regulating IFN-\u03b3 response and ROR\u03b3t localization","volume":"44","author":"McGuire","year":"2014","journal-title":"Eur J Immunol"},{"issue":"4","key":"2023061218532922100_bib138","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.immuni.2011.01.020","article-title":"Th17 cells express interleukin-10 receptor and are controlled by Foxp3\u2212 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner","volume":"34","author":"Huber","year":"2011","journal-title":"Immunity"},{"issue":"13","key":"2023061218532922100_bib139","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1158\/0008-5472.CAN-09-0266","article-title":"Malignant B cells skew the balance of regulatory T cells and TH17 cells in B-cell non-Hodgkin's lymphoma","volume":"69","author":"Yang","year":"2009","journal-title":"Cancer Res"},{"issue":"3","key":"2023061218532922100_bib140","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3324\/haematol.2012.072835","article-title":"Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy","volume":"98","author":"Weinkove","year":"2013","journal-title":"Haematologica"},{"issue":"11","key":"2023061218532922100_bib141","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.it.2019.09.008","article-title":"Immune networks and therapeutic targeting of iNKT cells in cancer","volume":"40","author":"Fujii","year":"2019","journal-title":"Trends Immunol"},{"issue":"4","key":"2023061218532922100_bib142","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/path.2667","article-title":"Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques","volume":"220","author":"De Boer","year":"2010","journal-title":"J\u00a0Pathol"},{"issue":"8","key":"2023061218532922100_bib143","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.4049\/jimmunol.0902995","article-title":"Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice","volume":"184","author":"de la Luz Garcia-Hernandez","year":"2010","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"2023061218532922100_bib144","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1182\/blood-2009-02-203935","article-title":"Type 17 CD8+ T cells display enhanced antitumor immunity","volume":"114","author":"Hinrichs","year":"2009","journal-title":"Blood"},{"issue":"12","key":"2023061218532922100_bib145","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/intimm\/dxr086","article-title":"IL-17\/IFN-\u03b3 double producing CD8+ T (Tc17\/IFN-\u03b3) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12","volume":"23","author":"Tajima","year":"2011","journal-title":"Int Immunol"},{"issue":"11","key":"2023061218532922100_bib146","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1038\/s41375-021-01249-7","article-title":"Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL","volume":"35","author":"Ferrer","year":"2021","journal-title":"Leukemia"},{"issue":"7","key":"2023061218532922100_bib147","doi-asserted-by":"crossref","first-page":"e21556","DOI":"10.1096\/fj.202100013R","article-title":"Activated Galectin-9\/Tim3 promotes Treg and suppresses Th1 effector function in chronic lymphocytic leukemia","volume":"35","author":"Pang","year":"2021","journal-title":"Faseb J"},{"issue":"11","key":"2023061218532922100_bib148","doi-asserted-by":"crossref","first-page":"7602","DOI":"10.4049\/jimmunol.0901881","article-title":"CD39+ Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis","volume":"183","author":"Fletcher","year":"2009","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"2023061218532922100_bib149","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1084\/jem.179.3.999","article-title":"Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells","volume":"179","author":"Lotz","year":"1994","journal-title":"J\u00a0Exp Med"},{"issue":"1","key":"2023061218532922100_bib150","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/ar3736","article-title":"Interleukin-10 produced by B cells is crucial for the suppression of Th17\/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis","volume":"14","author":"Carter","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"2023061218532922100_bib151","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.clim.2012.01.004","article-title":"Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner","volume":"143","author":"Oomizu","year":"2012","journal-title":"Clin Immunol"},{"issue":"4","key":"2023061218532922100_bib152","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1182\/blood.V100.4.1215.h81602001215_1215_1219","article-title":"The clinical significance of tumor necrosis factor-\u03b1 plasma level in patients having chronic lymphocytic leukemia","volume":"100","author":"Ferrajoli","year":"2002","journal-title":"Blood"},{"issue":"5","key":"2023061218532922100_bib153","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/cncr.10772","article-title":"Prognostic value of plasma interleukin-6 levels in patients with chronic lymphocytic leukemia","volume":"95","author":"Lai","year":"2002","journal-title":"Cancer"},{"issue":"3","key":"2023061218532922100_bib154","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3324\/haematol.2010.031377","article-title":"Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2","volume":"96","author":"Schulz","year":"2011","journal-title":"Haematologica"},{"issue":"5","key":"2023061218532922100_bib155","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1084\/jem.176.5.1319","article-title":"Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression","volume":"176","author":"Dancescu","year":"1992","journal-title":"J\u00a0Exp Med"},{"key":"2023061218532922100_bib156","first-page":"236","article-title":"Apoptosis in pathogenesis of B-cell chronic lymphocytic leukemia","volume":"58","author":"Podhorecka","year":"2004","journal-title":"Postepy Hig Med Dosw (Online)"},{"issue":"5","key":"2023061218532922100_bib157","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.gene.6363773","article-title":"Cell cycle effects of IL-10 on malignant B-1 cells","volume":"2","author":"Yen Chong","year":"2001","journal-title":"Genes Immun"},{"issue":"4","key":"2023061218532922100_bib158","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2011.03.018","article-title":"Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation","volume":"34","author":"Chaudhry","year":"2011","journal-title":"Immunity"},{"key":"2023061218532922100_bib159","doi-asserted-by":"crossref","first-page":"618110","DOI":"10.3389\/fimmu.2021.618110","article-title":"Interleukin-22 influences the Th1\/Th17 axis","volume":"12","author":"Lindahl","year":"2021","journal-title":"Front Immunol"},{"issue":"12","key":"2023061218532922100_bib160","doi-asserted-by":"crossref","first-page":"e51339","DOI":"10.1371\/journal.pone.0051339","article-title":"Th22 cells as well as Th17 cells expand differentially in patients with early-stage and late-stage myelodysplastic syndrome","volume":"7","author":"Shao","year":"2012","journal-title":"PLoS One"},{"key":"2023061218532922100_bib161","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cca.2013.09.014","article-title":"Increased Th22 cells as well as Th17 cells in patients with adult T-cell acute lymphoblastic leukemia","volume":"426","author":"Tian","year":"2013","journal-title":"Clin Chim Acta"},{"issue":"2","key":"2023061218532922100_bib162","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.3390\/ijms15021927","article-title":"Elevated Th22 cells correlated with Th17 cells in peripheral blood of patients with acute myeloid leukemia","volume":"15","author":"Yu","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"7","key":"2023061218532922100_bib163","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1084\/jem.20090207","article-title":"IL-17 can promote tumor growth through an IL-6\u2013Stat3 signaling pathway","volume":"206","author":"Wang","year":"2009","journal-title":"J\u00a0Exp Med"},{"issue":"9","key":"2023061218532922100_bib164","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.4049\/jimmunol.1000142","article-title":"IL-17 enhancement of the IL-6 signaling cascade in astrocytes","volume":"184","author":"Ma","year":"2010","journal-title":"J\u00a0Immunol"},{"issue":"6","key":"2023061218532922100_bib165","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/j.1365-2141.2009.08014.x","article-title":"Lenalidomide treatment of chronic lymphocytic leukaemia patients reduces regulatory T cells and induces Th17\u00a0T helper cells","volume":"148","author":"Idler","year":"2010","journal-title":"Br J Haematol"},{"issue":"1","key":"2023061218532922100_bib166","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00262-016-1922-6","article-title":"Phase I\u2013II study of lenalidomide and alemtuzumab in refractory chronic lymphocytic leukemia (CLL): effects on T cells and immune checkpoints","volume":"66","author":"Winqvist","year":"2017","journal-title":"Cancer Immunol Immunother"},{"issue":"8","key":"2023061218532922100_bib167","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1172\/JCI89756","article-title":"Ibrutinib treatment improves T cell number and function in CLL patients","volume":"127","author":"Long","year":"2017","journal-title":"J\u00a0Clin Invest"},{"key":"2023061218532922100_bib168","doi-asserted-by":"crossref","first-page":"637186","DOI":"10.3389\/fonc.2021.637186","article-title":"TH2\/TH1 shift under ibrutinib treatment in chronic lymphocytic leukemia","volume":"11","author":"Puzzolo","year":"2021","journal-title":"Front Oncol"},{"issue":"3","key":"2023061218532922100_bib169","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41375-021-01441-9","article-title":"A\u00a0T cell inflammatory phenotype is associated with autoimmune toxicity of the PI3K inhibitor duvelisib in chronic lymphocytic leukemia","volume":"36","author":"Gadi","year":"2022","journal-title":"Leukemia"},{"key":"2023061218532922100_bib170","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1182\/blood-2019-122961","article-title":"Imbalance in T cell subsets triggers the autoimmune toxicity of PI3K inhibitors in CLL","volume":"134","author":"Gadi","year":"2019","journal-title":"Blood"},{"issue":"15","key":"2023061218532922100_bib171","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1182\/blood-2013-06-507947","article-title":"Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes","volume":"122","author":"Dubovsky","year":"2013","journal-title":"Blood"},{"issue":"1","key":"2023061218532922100_bib172","doi-asserted-by":"crossref","first-page":"e1057385","DOI":"10.1080\/2162402X.2015.1057385","article-title":"Ibrutinib enhances IL-17 response by modulating the function of bone marrow derived dendritic cells","volume":"5","author":"Natarajan","year":"2016","journal-title":"OncoImmunology"},{"issue":"7","key":"2023061218532922100_bib173","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1158\/1078-0432.CCR-15-1965","article-title":"Disruption of in\u00a0vivo chronic lymphocytic leukemia tumor\u2013microenvironment interactions by ibrutinib\u2013findings from an investigator-initiated phase II study","volume":"22","author":"Niemann","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"4","key":"2023061218532922100_bib174","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.immuni.2009.07.009","article-title":"Differential expression of interleukin-17A and-17F is coupled to T cell receptor signaling via inducible T cell kinase","volume":"31","author":"Gomez-Rodriguez","year":"2009","journal-title":"Immunity"},{"issue":"5","key":"2023061218532922100_bib175","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/ijc.32201","article-title":"Idelalisib for optimized CD19-specific chimeric antigen receptor T cells in chronic lymphocytic leukemia patients","volume":"145","author":"Stock","year":"2019","journal-title":"Int J Cancer"},{"issue":"16","key":"2023061218532922100_bib176","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1056\/NEJMoa1407222","article-title":"Chimeric antigen receptor T cells for sustained remissions in leukemia","volume":"371","author":"Maude","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"2023061218532922100_bib177","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJMe2118899","article-title":"CAR T-cell therapy for large B-cell lymphoma - who, when, and how?","volume":"386","author":"Roschewski","year":"2022","journal-title":"N Engl J Med"},{"issue":"303","key":"2023061218532922100_bib178","doi-asserted-by":"crossref","first-page":"303ra139","DOI":"10.1126\/scitranslmed.aac5415","article-title":"Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia","volume":"7","author":"Porter","year":"2015","journal-title":"Sci Transl Med"},{"issue":"26","key":"2023061218532922100_bib179","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1016\/j.cell.2021.11.018","article-title":"Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity","volume":"184","author":"Schnell","year":"2021","journal-title":"Cell"},{"issue":"8","key":"2023061218532922100_bib180","doi-asserted-by":"crossref","first-page":"e90547","DOI":"10.1172\/jci.insight.90547","article-title":"\u03b2-catenin and PI3K\u03b4 inhibition expands precursor Th17 cells with heightened stemness and antitumor activity","volume":"2","author":"Majchrzak","year":"2017","journal-title":"JCI insight"},{"issue":"5","key":"2023061218532922100_bib181","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41591-018-0010-1","article-title":"Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia","volume":"24","author":"Fraietta","year":"2018","journal-title":"Nat Med"}],"container-title":["Blood Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article-pdf\/7\/11\/2401\/2056882\/blooda_adv-2022-008985-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article-pdf\/7\/11\/2401\/2056882\/blooda_adv-2022-008985-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T18:55:28Z","timestamp":1686596128000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/bloodadvances\/article\/7\/11\/2401\/493889\/The-role-of-Th17-cells-in-chronic-lymphocytic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,26]]},"references-count":181,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,6,13]]}},"URL":"https:\/\/doi.org\/10.1182\/bloodadvances.2022008985","relation":{},"ISSN":["2473-9529","2473-9537"],"issn-type":[{"value":"2473-9529","type":"print"},{"value":"2473-9537","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,26]]}}}