{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:30:58Z","timestamp":1788348658646,"version":"build-2803163510"},"reference-count":57,"publisher":"American Society of Hematology","issue":"18","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic graft-versus-host disease (cGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Mature donor T cells within the graft contribute to severe damage of thymic epithelial cells (TECs), which are known as key mediators in the continuum of acute GVHD (aGVHD) and cGVHD pathology. Mesenchymal stromal cells (MSCs) are reportedly effective in the prevention and treatment of cGVHD. In our previous pilot clinical trial in patients with refractory aGVHD, the incidence and severity of cGVHD were decreased, along with an increase in levels of blood signal joint T-cell receptor excision DNA circles after MSCs treatment, which indicated an improvement in thymus function of patients with GVHD, but the mechanisms leading to these effects remain unknown. Here, we show in a murine GVHD model that MSCs promoted the quantity and maturity of TECs as well as elevated the proportion of Aire-positive medullary TECs, improving both CD4+CD8+ double-positive thymocytes and thymic regulatory T cells, balancing the CD4:CD8 ratio in the blood. In addition, CCL25-CCR9 signaling axis was found to play an important role in guiding MSC homing to the thymus. These studies reveal mechanisms through which MSCs ameliorate cGVHD by boosting thymic regeneration and offer innovative strategies for improving thymus function in patients with GVHD.<\/jats:p>","DOI":"10.1182\/bloodadvances.2022009646","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T13:04:09Z","timestamp":1687784649000},"page":"5359-5373","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":21,"title":["Mesenchymal stromal cells ameliorate chronic GVHD by boosting thymic regeneration in a CCR9-dependent manner in mice"],"prefix":"10.1182","volume":"7","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"1Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China"},{"name":"2Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, 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Nanfang Hospital, Southern Medical University, Guangzhou, China"},{"name":"3Clinical Medical Research Center of Hematology Diseases of Guangdong Province, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Lin","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China"},{"name":"3Clinical Medical Research Center of Hematology Diseases of Guangdong Province, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China"},{"name":"3Clinical Medical Research Center of Hematology Diseases of Guangdong Province, Guangzhou, 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