{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:05:47Z","timestamp":1783688747290,"version":"3.55.0"},"reference-count":25,"publisher":"American Society of Hematology","issue":"9","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,14]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients treated with antineoplastic therapy often develop thrombocytopenia requiring platelet transfusion, which has potential to exacerbate pulmonary injury. This study tested the hypothesis that amotosalen-UVA pathogen\u2013reduced platelet components (PRPCs) do not potentiate pulmonary dysfunction compared with conventional platelet components (CPCs). A prospective, multicenter, open-label, sequential cohort study evaluated the incidence of treatment-emergent assisted mechanical ventilation initiated for pulmonary dysfunction (TEAMV-PD). The first cohort received CPC. After the CPC cohort, each site enrolled a second cohort transfused with PRPC. Other outcomes included clinically significant pulmonary adverse events (CSPAE) and the incidence of treatment-emergent acute respiratory distress syndrome (TEARDS) diagnosed by blinded expert adjudication. The incidence of TEAMV-PD in all patients (1068 PRPC and 1223 CPC) was less for PRPC (1.7 %) than CPC (3.1%) with a treatment difference of \u20131.5% (95% confidence interval [CI], \u20132.7 to \u20130.2). In patients requiring \u22652 PCs, the incidence of TEAMV-PD was reduced for PRPC recipients compared with CPC recipients (treatment difference, \u20132.4%; 95%\u00a0CI, \u20134.2 to \u20130.6). CSPAE increased with increasing PC exposure but were not significantly different between the cohorts. For patients receiving \u22652 platelet transfusions, TEARDS occurred in 1.3% PRPC and 2.6% CPC recipients (P\u00a0= .086). Bayesian analysis demonstrated PRPC may be superior in reducing TEAMV-PD and TEARDS for platelet transfusion recipients compared with CPC recipients, with 99.2% and 88.8% probability, respectively. In this study, PRPC compared with CPC demonstrated high probability of reduced severe pulmonary injury requiring assisted mechanical ventilation in patients with hematology disorders dependent on platelet transfusion. This trial was registered at www.ClinicalTrials.gov as #NCT02549222.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/bloodadvances.2023012425","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T21:10:20Z","timestamp":1709759420000},"page":"2290-2299","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":5,"title":["Acute pulmonary injury in hematology patients supported with pathogen-reduced and conventional platelet components"],"prefix":"10.1182","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-4873","authenticated-orcid":false,"given":"Allison P.","family":"Wheeler","sequence":"first","affiliation":[{"name":"1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Snyder","sequence":"additional","affiliation":[{"name":"2Laboratory Medicine, Transfusion Service, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed","family":"Refaai","sequence":"additional","affiliation":[{"name":"3Transfusion Service, University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-0470","authenticated-orcid":false,"given":"Claudia S.","family":"Cohn","sequence":"additional","affiliation":[{"name":"4Blood Bank Laboratory, University of Minnesota Medical Center, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Poisson","sequence":"additional","affiliation":[{"name":"5Department of Pathology, Duke University Medical Center, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-9516","authenticated-orcid":false,"given":"Magali","family":"Fontaine","sequence":"additional","affiliation":[{"name":"6Transfusion Service, University of Maryland Medical Center, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Sehl","sequence":"additional","affiliation":[{"name":"7Hematology Oncology, UCLA Medical Center, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay K.","family":"Nooka","sequence":"additional","affiliation":[{"name":"8Hematology Oncology, Emory University Medical Center, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Uhl","sequence":"additional","affiliation":[{"name":"9Laboratory and Transfusion Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Spinella","sequence":"additional","affiliation":[{"name":"10Surgery and Critical Care, University of Pittsburgh Medical Center, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1959-4489","authenticated-orcid":false,"given":"Maly","family":"Fenelus","sequence":"additional","affiliation":[{"name":"11Pathology, Clinical Laboratory, Memorial-Sloan Kettering Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darla","family":"Liles","sequence":"additional","affiliation":[{"name":"12Hematology Oncology, East Carolina University Medical Center, Greenville, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Coyle","sequence":"additional","affiliation":[{"name":"13Oncology, TriHealth Medical Center, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Becker","sequence":"additional","affiliation":[{"name":"14Pathology, Transfusion Medicine, Roswell Park Medical Center, Buffalo, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-8484","authenticated-orcid":false,"given":"Michael","family":"Jeng","sequence":"additional","affiliation":[{"name":"15Pediatric Hematology Oncology, Stanford University School of Medicine, Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Gehrie","sequence":"additional","affiliation":[{"name":"16Transfusion Medicine, Johns Hopkins Medical Institute, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-9154","authenticated-orcid":false,"given":"Bryan R.","family":"Spencer","sequence":"additional","affiliation":[{"name":"17American Red Cross Scientific Affairs, Dedham, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pampee","family":"Young","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Johnson","sequence":"additional","affiliation":[{"name":"4Blood Bank Laboratory, University of Minnesota Medical Center, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"18Transfusion Medicine, Mayo Clinic Florida, Jacksonville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Schiller","sequence":"additional","affiliation":[{"name":"21Hematology Oncology, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-2252","authenticated-orcid":false,"given":"John D.","family":"Roback","sequence":"additional","affiliation":[{"name":"8Hematology Oncology, Emory University Medical Center, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Malynn","sequence":"additional","affiliation":[{"name":"9Laboratory and Transfusion Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Jackups","sequence":"additional","affiliation":[{"name":"19Department of Pathology, Washington University St. Louis, St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-9704","authenticated-orcid":false,"given":"Scott T.","family":"Avecilla","sequence":"additional","affiliation":[{"name":"11Pathology, Clinical 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