{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:40:23Z","timestamp":1788795623309,"version":"build-2803163510"},"reference-count":67,"publisher":"American Society of Hematology","issue":"21","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"<jats:sec>\n                  <jats:title>Abstract<\/jats:title>\n                  <jats:p>Although patients with homozygous sickle cell anemia (SCA) carry both significant left atrial (LA) remodeling and an increased risk of stroke, the prevalence of atrial arrhythmia (AA) has never been prospectively evaluated. The aim of this study was to identify the prevalence and predictors of atrial arrhythmia in SCA. From 2018 to 2022, consecutive adult patients with SCA were included in the DREPACOEUR prospective registry and referred to the physiology department for cardiac evaluation, including a 24-hour electrocardiogram monitoring (ECG-Holter). The primary endpoint was the occurrence of AA, defined by the presence of excessive supraventricular ectopic activity (ESVEA) on ECG-Holter (ie &amp;gt;720 premature atrial contractions [PACs] or any run \u2265 20 PACs) or any recent history of atrial fibrillation. Overall, 130 patients with SCA (mean age: 45\u00b112 years, 48% of male) were included. AA was found in 34 (26%) patients. Age (52\u00b19 vs. 42\u00b112 years, P=0,002), LA dilation (LAVi, 71\u00b124 vs. 52\u00b114 mL\/m\u00b2, P&amp;lt;0.001) and history of stroke without underlying cerebral vasculopathy (26% vs. 5%, P=0.009, OR=6.6 (95%CI 1.4-30.3]) were independently associated with AA. Age and LAVi correlated with PAC load per 24 hours on ECG-Holter. An age over 47 years or a LAVi &amp;gt;55mL\/m\u00b2 could predict AA with a PPV of 33% and a NPV of 92%. AAs are frequent in middle-aged patients with SCA and increase with age and LA remodeling, leading to a major additional risk factor for ischemic stroke. This study provides arguments and means to early screen for AA and potentially prevent cerebral complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1182\/bloodadvances.2024013208","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T21:13:23Z","timestamp":1722460403000},"page":"5625-5638","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":14,"title":["Atrial arrhythmia in adults with sickle cell anemia: a missing link toward understanding and preventing strokes"],"prefix":"10.1182","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-0962","authenticated-orcid":false,"given":"Thomas","family":"d\u2019Humi\u00e8res","sequence":"first","affiliation":[{"name":"1Physiology Department, FHU SENEC, Henri Mondor Hospital, Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"2INSERM IMRB U955, Universit\u00e9 Paris Est, Cr\u00e9teil, France"},{"name":"3Sickle Cell Referral Center-UMGGR, Plateforme d\u2019expertise Maladies Rares Grand Paris Est, Universit\u00e9 Paris Est, FHU SENEC, CHU Henri Mondor Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"4Paris Cardiovascular Research Center-PARCC, Inserm, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zineb","family":"Sadraoui","sequence":"additional","affiliation":[{"name":"1Physiology Department, FHU SENEC, Henri Mondor Hospital, Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Savale","sequence":"additional","affiliation":[{"name":"5Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, H\u00f4pital Bic\u00eatre, Assistance Publique H\u00f4pitaux de Paris, Le Kremlin-Bic\u00eatre, France"},{"name":"6Universit\u00e9 Paris-Saclay, School of Medicine, Le Kremlin-Bic\u00eatre, France"},{"name":"7INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies, H\u00f4pital Marie Lannelongue, Le Plessis-Robinson, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Boyer","sequence":"additional","affiliation":[{"name":"1Physiology Department, FHU SENEC, Henri Mondor Hospital, Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"2INSERM IMRB U955, Universit\u00e9 Paris Est, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Guillet","sequence":"additional","affiliation":[{"name":"3Sickle Cell Referral Center-UMGGR, Plateforme d\u2019expertise Maladies Rares Grand Paris Est, Universit\u00e9 Paris Est, FHU SENEC, CHU Henri Mondor Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"8Department of Internal Medicine, Henri Mondor University Hospital, Universit\u00e9 Paris 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihem","family":"Iles","sequence":"additional","affiliation":[{"name":"1Physiology Department, FHU SENEC, Henri Mondor Hospital, Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-4804","authenticated-orcid":false,"given":"Paul","family":"Balfanz","sequence":"additional","affiliation":[{"name":"1Physiology Department, FHU SENEC, Henri Mondor Hospital, Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"2INSERM IMRB U955, Universit\u00e9 Paris Est, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-7367","authenticated-orcid":false,"given":"Anoosha","family":"Habibi","sequence":"additional","affiliation":[{"name":"3Sickle Cell Referral Center-UMGGR, Plateforme d\u2019expertise Maladies Rares Grand Paris Est, Universit\u00e9 Paris Est, FHU SENEC, CHU Henri Mondor Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"8Department of Internal Medicine, Henri Mondor University Hospital, Universit\u00e9 Paris Est\/Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suella","family":"Martino","sequence":"additional","affiliation":[{"name":"3Sickle Cell Referral Center-UMGGR, Plateforme d\u2019expertise Maladies Rares Grand Paris Est, Universit\u00e9 Paris Est, FHU SENEC, CHU Henri Mondor Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"},{"name":"8Department of Internal Medicine, Henri Mondor University Hospital, Universit\u00e9 Paris Est\/Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziana","family":"Amorouayeche","sequence":"additional","affiliation":[{"name":"1Physiology Department, FHU SENEC, 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