{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:36:49Z","timestamp":1793824609313,"version":"4.6.1"},"reference-count":47,"publisher":"American Society of Hematology","issue":"21","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Platelets are crucial in thrombus formation during ST-elevation myocardial infarction (STEMI). In addition, they also play an important role in postischemic thromboinflammation, which is determined by the interplay between activated platelets and neutrophils. The latter form neutrophil extracellular traps, which are detectable in plasma as citrullinated histone H3\u2013deoxyribonucleic acid-DNA complexes. Prediction of the risk of recurrent events is important in precision medicine. Therefore, we investigated whether circulating thromboinflammatory markers predict clinical outcome after STEMI. We performed a prospective, multicentric, observational, all-comer study of patients with STEMI (n\u00a0=\u00a0361). Thromboinflammation, measured as H3Cit-DNA complexes, was assessed on day 1 after presentation with STEMI as well as 5\u00a0days and 6\u00a0months after STEMI by enzyme-linked immunosorbent assay. Twelve months of clinical follow-up was conducted. Multivariate analysis was performed investigating which variables were independently associated with major adverse cardiac events (MACEs). Patients were aged 64\u00a0\u00b1 12 years; 80% were male; and 40% had diabetes mellitus. Thromboinflammation was enhanced during index hospitalization compared with 6-months follow-up (137.4\u00a0\u00b1 100.0\u00a0\u03bcg\/L vs 53.7\u00a0\u00b1 54.7\u00a0\u03bcg\/L; P\u00a0&amp;lt; .001). Additionally, patients within the highest tertile of thromboinflammation at day 1 after STEMI showed worse outcome during follow-up (hazard ratio, 2.57; 95% confidence interval, 1.72-3.85; P\u00a0&amp;lt; .001). Receiver operating characteristic analysis revealed a cutoff value of 219.3\u00a0\u03bcg\/L. In multivariate logistic regression analysis, thromboinflammation was independently associated with outcome after STEMI. To sum it up, thromboinflammation is enhanced in STEMI. It identifies patients at high risk of MACE. Therefore, thromboinflammation might\u00a0be a promising target and marker in precision medicine. The trial was registered at\u00a0www.clinicaltrials.gov as #NCT03539133.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1182\/bloodadvances.2024014273","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T15:39:17Z","timestamp":1725377957000},"page":"5581-5589","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":25,"title":["Thromboinflammation is associated with clinical outcome after ST-elevation myocardial infarction"],"prefix":"10.1182","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-7421","authenticated-orcid":false,"given":"Marcel","family":"Benkhoff","sequence":"first","affiliation":[{"name":"1Department of Cardiology, Pulmonology, and Vascular Medicine, University Hospital D\u00fcsseldorf, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"},{"name":"2Institute of Analytical Chemistry, University of Vienna, Vienna, 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Cardiology, Pulmonology, and Vascular Medicine, University Hospital D\u00fcsseldorf, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"},{"name":"6Cardiovascular Research Institute D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-5632","authenticated-orcid":false,"given":"Tobias","family":"Petzold","sequence":"additional","affiliation":[{"name":"3Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany"},{"name":"4German Centre for Cardiovascular Research, Partner Site Berlin, Berlin, Germany"},{"name":"5Friede Springer-Centre of Cardiovascular Prevention at Charit\u00e9, Charit\u00e9-University Medicine Berlin, Berlin, 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