{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:07:19Z","timestamp":1794002839277,"version":"4.8.0"},"reference-count":40,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Platelets express ABO antigens and are collected in plasma, which contains ABO antibodies as would be consistent with the donor ABO group. Platelet ABO antigens that are incompatible with recipient ABO antibodies may have accelerated clearance from circulation and result in lower count increments. ABO antibodies that are passively transferred from donor plasma may result in hemolysis of recipient red blood cells. Although platelets do not express Rh antigens, they contain small numbers of intact red blood cells or fragments, which can lead to alloimmunization in the recipient. Alloimmunization to the RhD antigen may occur when platelets obtained from RhD-positive donors are transfused to RhD-negative recipients. All of these compatibility considerations must be balanced against the available supply, which may be limited due to the 5- to 7-day shelf life of platelets. This articles describes considerations for platelet ABO and RhD selection for platelet transfusions, including the impact of major ABO incompatibility on count increments, the risks of hemolysis associated with minor ABO incompatibility, and the risk of RhD alloimmunization when RhD-negative patients receive platelets obtained from RhD-positive donors.<\/jats:p>","DOI":"10.1182\/hematology.2020000135","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T03:28:38Z","timestamp":1607138918000},"page":"512-517","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":58,"title":["Does ABO and RhD matching matter for platelet transfusion?"],"prefix":"10.1182","volume":"2020","author":[{"given":"Nancy M.","family":"Dunbar","sequence":"first","affiliation":[{"name":"Dartmouth-Hitchcock Medical Center, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"4","key":"2020121621255959200_B1","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1182\/blood.V96.4.1574","article-title":"Blood group A and B antigens are strongly expressed on platelets of some individuals","volume":"96","author":"Curtis","year":"2000","journal-title":"Blood"},{"key":"2020121621255959200_B2","volume-title":"Standards for Blood Banks and Transfusion Services","author":"American Association of Blood Banks","year":"2020","edition":"32nd ed."},{"issue":"3","key":"2020121621255959200_B3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000351230","article-title":"Platelet transfusion - the art and science of compromise","volume":"40","author":"Cid","year":"2013","journal-title":"Transfus Med Hemother"},{"issue":"8","key":"2020121621255959200_B4","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1111\/trf.13077","article-title":"Easier said than done: ABO compatibility and D matching in apheresis platelet transfusions","volume":"55","author":"Dunbar","year":"2015","journal-title":"Transfusion"},{"issue":"3","key":"2020121621255959200_B5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1537-2995.2011.03329.x","article-title":"Providing ABO-identical platelets and cryoprecipitate to (almost) all patients: approach, logistics, and associated decreases in transfusion reaction and red blood cell alloimmunization incidence","volume":"52","author":"Henrichs","year":"2012","journal-title":"Transfusion"},{"issue":"11","key":"2020121621255959200_B6","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1111\/j.1537-2995.2009.02273.x","article-title":"ABO-identical versus nonidentical platelet transfusion: a systematic review","volume":"49","author":"Shehata","year":"2009","journal-title":"Transfusion"},{"issue":"3","key":"2020121621255959200_B7","first-page":"411","article-title":"Transfusion of ABO non-identical platelets does not influence the clinical outcome of patients undergoing autologous haematopoietic stem cell transplantation","volume":"13","author":"Solves","year":"2015","journal-title":"Blood Transfus"},{"issue":"2","key":"2020121621255959200_B8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/trf.15655","article-title":"ABO-incompatible platelets are associated with increased transfusion reaction rates","volume":"60","author":"Malvik","year":"2020","journal-title":"Transfusion"},{"issue":"1","key":"2020121621255959200_B9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/trf.12791","article-title":"Transfusion-related adverse events in the Platelet Dose study","volume":"55","author":"Kaufman","year":"2015","journal-title":"Transfusion"},{"issue":"1","key":"2020121621255959200_B10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/trf.15637","article-title":"The epidemiology of platelet transfusions: an analysis of platelet use at 12 US hospitals","volume":"60","author":"Gottschall","year":"2020","journal-title":"Transfusion"},{"issue":"23","key":"2020121621255959200_B11","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1182\/blood-2011-11-393165","article-title":"The impact of platelet transfusion characteristics on posttransfusion platelet increments and clinical bleeding in patients with hypoproliferative thrombocytopenia","volume":"119","author":"Triulzi","year":"2012","journal-title":"Blood"},{"key":"2020121621255959200_B12","unstructured":"US Food and Drug Administration. 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