{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:05:26Z","timestamp":1775883926951,"version":"3.50.1"},"reference-count":21,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Prophylactic platelet transfusions are used to reduce the risk of spontaneous bleeding in patients with treatment- or disease-related severe thrombocytopenia. A prophylactic platelet-transfusion threshold of &amp;lt;10 \u00d7 103\/\u00b5L has been shown to be safe in stable hematology\/oncology patients. A higher threshold and\/or larger or more frequent platelet doses may be appropriate for patients with clinical features associated with an increased risk of bleeding such as high fevers, sepsis, disseminated intravascular coagulation, anticoagulation therapy, or splenomegaly. Unique factors in the outpatient setting may support the use of a higher platelet-transfusion threshold and\/or dose of platelets. A prophylactic platelet-transfusion strategy has been shown to be associated with a lower risk of bleeding compared with no prophylaxis in adult patients receiving chemotherapy but not for autologous transplant recipients. Despite the use of prophylactic platelet transfusions, a high incidence (50% to 70%) of spontaneous bleeding remains. Using a higher threshold or larger doses of platelets does not change this risk. New approaches to reduce the risk of spontaneous bleeding, including antifibrinolytic therapy, are currently under study.<\/jats:p>","DOI":"10.1182\/hematology.2020000136","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T03:30:05Z","timestamp":1607139005000},"page":"518-522","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":17,"title":["How well do platelets prevent bleeding?"],"prefix":"10.1182","volume":"2020","author":[{"given":"Darrell J.","family":"Triulzi","sequence":"first","affiliation":[{"name":"University of Pittsburgh, Vitalant Clinical Services, Pittsburgh, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"issue":"7","key":"2020121621260070100_B1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1056\/NEJMoa0904084","article-title":"Dose of prophylactic platelet transfusions and prevention of hemorrhage","volume":"362","author":"Slichter","year":"2010","journal-title":"N Engl J Med"},{"issue":"5","key":"2020121621260070100_B2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/blood.V66.5.1105.1105","article-title":"Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement","volume":"66","author":"Hanson","year":"1985","journal-title":"Blood"},{"issue":"1","key":"2020121621260070100_B3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/trf.15637","article-title":"The epidemiology of platelet transfusions: an analysis of platelet use at 12 US hospitals","volume":"60","author":"Gottschall","year":"2020","journal-title":"Transfusion"},{"issue":"6","key":"2020121621260070100_B4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/MOH.0b013e32834babf4","article-title":"New thoughts on the correct dosing of prophylactic platelet transfusions to prevent bleeding","volume":"18","author":"Slichter","year":"2011","journal-title":"Curr Opin Hematol"},{"issue":"26","key":"2020121621260070100_B5","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1056\/NEJM199712253372602","article-title":"The threshold for prophylactic platelet transfusions in adults with acute myeloid leukemia. 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