{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:18:04Z","timestamp":1790561884693,"version":"4.1.0"},"reference-count":59,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recurrent venous thromboembolism (VTE, or deep vein thrombosis and pulmonary embolism) is associated with mortality and long-term morbidity. The circumstances in which an index VTE event occurred are crucial when personalized VTE recurrence risk is assessed. Patients who experience a VTE event in the setting of a transient major risk factor (such as surgery associated with general anesthesia for &amp;gt;30 minutes) are predicted to have a low VTE recurrence risk following discontinuation of anticoagulation, and limited-duration anticoagulation is generally recommended. In contrast, those patients whose VTE event occurred in the absence of risk factors or who have persistent risk factors have a higher VTE recurrence risk. Here, we review the literature surrounding VTE recurrence risk in a range of clinical conditions. We describe gender-specific risks, including VTE recurrence risk following hormone- and pregnancy-associated VTE events. Finally, we discuss how the competing impacts of VTE recurrence and bleeding have shaped international guideline recommendations.<\/jats:p>","DOI":"10.1182\/hematology.2020002268","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T04:45:23Z","timestamp":1607143523000},"page":"201-212","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":18,"title":["Which patients are at high risk of recurrent venous thromboembolism (deep vein thrombosis and pulmonary embolism)?"],"prefix":"10.1182","volume":"2020","author":[{"given":"Fionnuala N\u00ed","family":"\u00c1inle","sequence":"first","affiliation":[{"name":"Department of Hematology, Mater University Hospital, Dublin, Ireland;"},{"name":"Department of Hematology, Rotunda Hospital, Dublin, Ireland;"},{"name":"School of Medicine, University College Dublin, Dublin, Ireland; and"},{"name":"Irish Network for VTE Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Kevane","sequence":"additional","affiliation":[{"name":"Department of Hematology, Mater University Hospital, Dublin, Ireland;"},{"name":"School of Medicine, University College Dublin, Dublin, Ireland; and"},{"name":"Irish Network for VTE Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"7","key":"2020121621272873500_B1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1111\/jth.13336","article-title":"Categorization of patients as having provoked or unprovoked venous thromboembolism: guidance from the SSC of ISTH","volume":"14","author":"Kearon","year":"2016","journal-title":"J Thromb Haemost"},{"issue":"4","key":"2020121621272873500_B2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in 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