{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:19:58Z","timestamp":1777317598074,"version":"3.51.4"},"reference-count":47,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The overlap in clinical presentation and bone marrow features of acquired and inherited causes of hypocellular marrow failure poses a significant diagnostic challenge in real case scenarios, particularly in nonsevere disease. The distinction between acquired aplastic anemia (aAA), hypocellular myelodysplastic syndrome (MDS), and inherited bone marrow failure syndromes presenting with marrow hypocellularity is critical to inform appropriate care. Here, we review the workup of hypocellular marrow failure in adolescents through adults. Given the limitations of relying on clinical stigmata or family history to identify patients with inherited etiologies, we outline a diagnostic approach incorporating comprehensive genetic testing in patients with hypocellular marrow failure that does not require immediate therapy and thus allows time to complete the evaluation. We also review the clinical utility of marrow array to detect acquired 6p copy number-neutral loss of heterozygosity to support a diagnosis of aAA, the complexities of telomere length testing in patients with aAA, short telomere syndromes, and other inherited bone marrow failure syndromes, as well as the limitations of somatic mutation testing for mutations in myeloid malignancy genes for discriminating between the various diagnostic possibilities.<\/jats:p>","DOI":"10.1182\/hematology.2021000244","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T12:08:19Z","timestamp":1639138099000},"page":"134-142","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":10,"title":["The clinical and laboratory evaluation of patients with suspected hypocellular marrow failure"],"prefix":"10.1182","volume":"2021","author":[{"given":"Siob\u00e1n","family":"Keel","sequence":"first","affiliation":[{"name":"University of Washington, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Geddis","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"issue":"3","key":"2021121012063907500_hem2021000244C1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1182\/blood.V45.3.355.355","article-title":"Selection of patients for bone marrow transplantation in severe aplastic anemia","volume":"45","author":"Camitta","year":"1975","journal-title":"Blood"},{"issue":"4","key":"2021121012063907500_hem2021000244C2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1309\/2Y7X-YDXK-006B-XLT2","article-title":"Bone marrow changes in anorexia nervosa are correlated with the amount of weight loss and not with other clinical findings","volume":"118","author":"Abella","year":"2002","journal-title":"Am J 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