{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:46:26Z","timestamp":1793324786063,"version":"4.5.0"},"reference-count":38,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Diagnosing amyloidosis can be challenging due to its clinical heterogeneity, need for multiple specialists to make a diagnosis, and lack of a single diagnostic test for the disease. Patients are often diagnosed late, in advanced stage, and after exhibiting multiple symptoms and signs for a long period. It is important to develop a clinical suspicion of amyloidosis, particularly in those with multisystemic symptoms and high-risk patient populations such as those with precursor hematologic conditions. A systematic approach to the workup of suspected amyloidosis is key, including a comprehensive clinical assessment, laboratory tests to assess organ involvement, advanced imaging studies, screening for plasma cell disorder, and tissue biopsy when necessary. After making a diagnosis of amyloidosis, accurate typing of amyloid deposits, differentiating between localized and systemic amyloidosis, and appropriately staging the disease is important. Early diagnosis is crucial for improving patient outcomes and quality of life in light chain amyloidosis.<\/jats:p>","DOI":"10.1182\/hematology.2023000440","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T15:11:16Z","timestamp":1702048276000},"page":"407-412","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":1,"title":["Amyloid consults do not have to be vexing"],"prefix":"10.1182","volume":"2023","author":[{"given":"Anita","family":"D'Souza","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"issue":"10","key":"2023120815065199600_hem2023000440C1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s12325-015-0250-0","article-title":"Light chain amyloidosis: patient experience survey from the amyloidosis research consortium","volume":"32","author":"Lousada","year":"2015","journal-title":"Adv Ther"},{"issue":"4","key":"2023120815065199600_hem2023000440C2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s11136-021-02943-w","article-title":"Development of a conceptual model of patient-reported outcomes in light chain amyloidosis: a qualitative study","volume":"31","author":"D'Souza","year":"2022","journal-title":"Qual Life Res"},{"issue":"4","key":"2023120815065199600_hem2023000440C3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/13506129.2022.2147636","article-title":"Amyloid nomenclature 2022: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee","volume":"29","author":"Buxbaum","year":"2022","journal-title":"Amyloid"},{"issue":"7","key":"2023120815065199600_hem2023000440C4","first-page":"e000030","article-title":"ASNC\/AHA\/ASE\/EANM\/HFSA\/ISA\/SCMR\/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: part 2 of 2-diagnostic criteria and appropriate utilization","volume":"14","author":"Dorbala","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"issue":"23","key":"2023120815065199600_hem2023000440C5","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1182\/blood.2020006913","article-title":"Management of AL amyloidosis in 2020","volume":"136","author":"Palladini","year":"2020","journal-title":"Blood"},{"issue":"3","key":"2023120815065199600_hem2023000440C6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.clml.2022.12.013","article-title":"A comprehensive multidisciplinary diagnostic algorithm for the early and efficient detection of amyloidosis","volume":"23","author":"Jimenez-Zepeda","year":"2023","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"2023120815065199600_hem2023000440C7","unstructured":"The great imitator. 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