{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:01:26Z","timestamp":1791277286295,"version":"4.1.0"},"reference-count":51,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with advanced chronic liver disease (CLD) often need procedures to both treat and prevent complications of portal hypertension such as ascites or gastrointestinal bleeding. Abnormal results for hemostatic tests, such as prolonged prothrombin time, international normalized ratio, and\/or thrombocytopenia, are commonly encountered, raising concerns about increased bleeding risk and leading to transfusion to attempt to correct prior to interventions. However hemostatic markers are poor predictors of bleeding risk in CLD, and routine correction, particularly with fresh frozen plasma and routine platelet transfusions, should be avoided. This narrative review discusses the hemostatic management of patients with CLD using 2 case descriptions.<\/jats:p>","DOI":"10.1182\/hematology.2023000480","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T15:09:13Z","timestamp":1702048153000},"page":"274-280","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":6,"title":["How to manage hemostasis in patients with liver disease during interventions"],"prefix":"10.1182","volume":"2023","author":[{"given":"Lara N.","family":"Roberts","sequence":"first","affiliation":[{"name":"King's Thrombosis Centre, Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"issue":"3","key":"2023120815055950900_hem2023000480C1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/ajg.2017.457","article-title":"Platelet count does not predict bleeding in cirrhotic patients: results from the PRO-LIVER Study","volume":"113","author":"Basili","year":"2018","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"2023120815055950900_hem2023000480C2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/hep.28628","article-title":"Coagulation parameters and major bleeding in critically ill patients with cirrhosis","volume":"64","author":"Drolz","year":"2016","journal-title":"Hepatology"},{"issue":"6","key":"2023120815055950900_hem2023000480C3","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1055\/a-1667-7293","article-title":"Prevalence of bleeding and thrombosis in critically ill patients with chronic liver disease","volume":"122","author":"Ow","year":"2022","journal-title":"Thromb Haemost"},{"issue":"1","key":"2023120815055950900_hem2023000480C4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/hep.31646","article-title":"Vascular liver disorders, portal vein thrombosis, and procedural bleeding in patients with liver disease: 2020 practice guidance by the American Association for the Study of Liver Diseases","volume":"73","author":"Northup","year":"2021","journal-title":"Hepatology"},{"issue":"5","key":"2023120815055950900_hem2023000480C5","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.jhep.2021.09.003","article-title":"EASL clinical practice guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis","volume":"76","author":"Villa","year":"2022","journal-title":"J Hepatol"},{"issue":"1","key":"2023120815055950900_hem2023000480C6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/jth.15562","article-title":"Periprocedural management of abnormal coagulation parameters and thrombocytopenia in patients with cirrhosis: guidance from the SSC of the ISTH","volume":"20","author":"Roberts","year":"2022","journal-title":"J Thromb Haemost"},{"issue":"5","key":"2023120815055950900_hem2023000480C7","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1053\/j.gastro.2021.08.015","article-title":"AGA clinical practice guideline on the management of coagulation disorders in patients with cirrhosis","volume":"161","author":"O'Shea","year":"2021","journal-title":"Gastroenterology"},{"key":"2023120815055950900_hem2023000480C8","unstructured":"Bent, C, Das, R, Gomez, K, Lester, WB; SIR Safety and Quality Committee; BSH Haemostasis and Thrombosis Task Force. 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