{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:19:41Z","timestamp":1787019581056,"version":"build-2736575974"},"reference-count":21,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the United States, more than 2 000 000 apheresis platelet units are collected annually from volunteer donors. Platelet donors in the United States and elsewhere are permitted to donate up to 24 times per year. Recently, frequent apheresis platelet donation has been associated with severe T-cell lymphopenia. Several frequent platelet donors have been found to have peripheral blood CD4+ T-cell counts below 200 cells\/\u00b5L, the threshold for AIDS in HIV-positive individuals. Independent risk factors for plateletpheresis-associated lymphopenia include lifetime donations, age, and donations on the Trima Accel instrument (Terumo BCT), which uses a leukoreduction system (LRS) chamber to trap white blood cells. Less often, severe lymphopenia can occur in donors collected on the Fenwal Amicus instrument (Fresenius Kabi), which has no LRS. For Trima Accel donors, lymphopenia can be partially mitigated by performing a plasma rinseback step at the end of collection. To date, there is no definitive evidence that plateletpheresis-associated lymphopenia is harmful. In a study of frequent platelet donors with lymphopenia who were administered COVID-19 messenger RNA vaccines, immune responses were normal. The homeostatic mechanisms responsible for maintaining a normal peripheral blood T-cell count remain obscure, as do the causal mechanisms underlying plateletpheresis-associated lymphopenia.<\/jats:p>","DOI":"10.1182\/hematology.2023000484","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T10:09:53Z","timestamp":1702030193000},"page":"305-310","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":2,"title":["T-cell lymphopenia in frequent volunteer platelet donors"],"prefix":"10.1182","volume":"2023","author":[{"given":"Richard M.","family":"Kaufman","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"issue":"1","key":"2023120815061653400_hem2023000484C1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1537-2995.1981.21181127485.x","article-title":"The safety of weekly plateletpheresis: effect on the donors' lymphocyte population","volume":"21","author":"Koepke","year":"1981","journal-title":"Transfusion"},{"key":"2023120815061653400_hem2023000484C2","unstructured":"U.S. Department of Health and Human Services, Food and Drug Administration, Center for Biologics Evaluation and Research, Guidance for Industry and FDA Review Staff Collection of Platelets by Automated Methods. Guidance-for-Industry-and-FDA-Review-Staff\u2014Collection-of-Platelets-by-Automated-Methods.pdf. Accessed August23, 2023."},{"issue":"7","key":"2023120815061653400_hem2023000484C3","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/j.1537-2995.2008.01785.x","article-title":"Risks of clinically significant thrombocytopenia and\/or lymphocytopenia in donors after multiple plateletpheresis collections","volume":"48","author":"Strauss","year":"2008","journal-title":"Transfusion"},{"issue":"6","key":"2023120815061653400_hem2023000484C4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1182\/blood-2018-09-873125","article-title":"Plateletpheresis-associated lymphopenia in frequent platelet donors","volume":"133","author":"Gansner","year":"2019","journal-title":"Blood"},{"issue":"12","key":"2023120815061653400_hem2023000484C5","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1111\/j.1537-2995.2006.01033.x","article-title":"A novel source of viable peripheral blood mononuclear cells from leukoreduction system chambers","volume":"46","author":"Dietz","year":"2006","journal-title":"Transfusion"},{"issue":"11","key":"2023120815061653400_hem2023000484C6","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1111\/trf.16666","article-title":"Total platelet donation count and donation frequency are determinants of plateletpheresis-associated lymphopenia","volume":"61","author":"Thuer","year":"2021","journal-title":"Transfusion"},{"key":"2023120815061653400_hem2023000484C7","unstructured":"Association for the Advancement of Blood and Biotherapies (AABB). Full-Length Blood Donor History Questionnaire (DHQ) v4.0. https:\/\/www.aabb.org\/docs\/default-source\/default-document-library\/resources\/dhq-v4-0\/pdfs\/dhq-v4-0.pdf?sfvrsn=c8022a9f_0. Accessed June3, 2023."},{"issue":"5","key":"2023120815061653400_hem2023000484C8","first-page":"68","article-title":"CD4+ T-cell lymphopenia in frequent platelet donors who have ceased platelet donation for at least 1year","volume":"2","author":"Rahmani","year":"2019","journal-title":"Transfusion"},{"issue":"2","key":"2023120815061653400_hem2023000484C9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/trf.16175","article-title":"Frequent platelet donation is associated with lymphopenia and risk of infections: a nationwide cohort study","volume":"61","author":"Zhao","year":"2021","journal-title":"Transfusion"},{"issue":"12","key":"2023120815061653400_hem2023000484C10","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1111\/trf.16027","article-title":"The Swedish Scandinavian donations and transfusions database (SCANDAT3-S)\u201450 years of donor and recipient 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