{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:57:26Z","timestamp":1790855846267,"version":"4.1.0"},"reference-count":26,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Iron deficiency is a very common and treatable disorder. Of all the tests available to diagnose iron deficiency, the serum ferritin is the most able to discriminate iron deficiency from other disorders. However, the reference range for ferritin in many laboratories will lead to underdiagnosis of iron deficiency in women. Studies have shown that 30%-50% of healthy women will have no marrow iron stores, so basing ferritin cutoffs on the lowest 2.5% of sampled ferritins is not appropriate. In addition, several lines of evidence suggest the body physiologic ferritin \u201ccutoff\u201d is 50\u200a\u2009ng\/mL. Work is needed to establish more realistic ferritin ranges to avoid underdiagnosing a readily treatable disorder.<\/jats:p>","DOI":"10.1182\/hematology.2023000494","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T15:13:45Z","timestamp":1702048425000},"page":"617-621","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":51,"title":["Sex, lies, and iron deficiency: a call to change ferritin reference ranges"],"prefix":"10.1182","volume":"2023","author":[{"given":"Kylee","family":"Martens","sequence":"first","affiliation":[{"name":"Knight Cancer Institute, Oregon Health & Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"DeLoughery","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute, Oregon Health & Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"issue":"10270","key":"2023120815080943900_hem2023000494C1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(20)32594-0","article-title":"Iron deficiency","volume":"397","author":"Pasricha","year":"2021","journal-title":"Lancet"},{"issue":"5","key":"2023120815080943900_hem2023000494C2","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfab021","article-title":"Chemistry and biology of ferritin","volume":"13","author":"Plays","year":"2021","journal-title":"Metallomics"},{"issue":"12","key":"2023120815080943900_hem2023000494C3","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/jn\/128.12.2295","article-title":"Iron regulatory proteins, iron responsive elements and iron homeostasis","volume":"128","author":"Eisenstein","year":"1998","journal-title":"J Nutr"},{"issue":"12","key":"2023120815080943900_hem2023000494C4","article-title":"The role of reticulocyte hemoglobin content for diagnosis of iron deficiency and iron deficiency anemia, and monitoring of iron therapy: a literature review","volume":"65","author":"Gelaw","year":"2019","journal-title":"Clin Lab"},{"issue":"10","key":"2023120815080943900_hem2023000494C5","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/jcp.26.10.770","article-title":"Serum ferritin concentration and iron stores in normal subjects","volume":"26","author":"Walters","year":"1973","journal-title":"J Clin Pathol"},{"issue":"2","key":"2023120815080943900_hem2023000494C6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF02598003","article-title":"Laboratory diagnosis of iron-deficiency anemia: an overview","volume":"7","author":"Guyatt","year":"1992","journal-title":"J Gen Intern Med"},{"issue":"5","key":"2023120815080943900_hem2023000494C7","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.beem.2015.09.003","article-title":"Beyond soluble transferrin receptor: old challenges and new horizons","volume":"29","author":"Harms","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"2023120815080943900_hem2023000494C8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/clinchem\/44.1.45","article-title":"Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations","volume":"44","author":"Mast","year":"1998","journal-title":"Clin Chem"},{"key":"2023120815080943900_hem2023000494C9","doi-asserted-by":"crossref","first-page":"378","DOI":"10.7326\/0003-4819-52-2-378","article-title":"Iron therapy in chronically fatigued, nonanemic women: a double-blind study","volume":"52","author":"Beutler","year":"1960","journal-title":"Ann Intern Med"},{"issue":"11","key":"2023120815080943900_hem2023000494C10","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1503\/cmaj.110950","article-title":"Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial","volume":"184","author":"Vaucher","year":"2012","journal-title":"CMAJ"},{"issue":"7399","key":"2023120815080943900_hem2023000494C11","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/bmj.326.7399.1124","article-title":"Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial","volume":"326","author":"Verdon","year":"2003","journal-title":"BMJ"},{"issue":"21","key":"2023120815080943900_hem2023000494C12","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/bjsports-2014-093624","article-title":"Is iron treatment beneficial in iron-deficient but non-anaemic (IDNA) endurance athletes? 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