{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T10:24:10Z","timestamp":1794306250359,"version":"4.9.0"},"reference-count":41,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Monoclonal gammopathy is observed in approximately 10% of patients with peripheral neuropathy, which is particularly common in those with the immunoglobulin M monoclonal component. The diagnostic challenge lies in determining whether the neuropathy is causally related to the paraprotein or merely coincidental. Physicians must be familiar with the spectrum of monoclonal gammopathy\u2013associated neuropathies, including anti\u2013myelin-associated glycoprotein neuropathy, amyloid light chain amyloidosis, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, CANOMAD (chronic ataxic neuropathy, ophthalmoplegia, IgM paraprotein, cold agglutinins, and disialosyl antibodies), and cryoglobulinemia, as well as their clinical, electrophysiologic, and immunologic characteristics. Initial workup includes serum protein electrophoresis, immunofixation, free light chain analysis, and targeted antibody testing based on the paraprotein and neuropathy phenotype. Close collaboration between neurologists and hematologist-oncologists is essential for accurate diagnosis and appropriate treatment, which may involve both immunotherapy and targeted therapies for the underlying hematologic disorder.<\/jats:p>","DOI":"10.1182\/hematology.2025000728","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T14:08:47Z","timestamp":1764943727000},"page":"385-392","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":3,"title":["Monoclonal-related neuropathies: diagnosis, prognosis, and outcomes"],"prefix":"10.1182","volume":"2025","author":[{"given":"Arnaud","family":"Jaccard","sequence":"first","affiliation":[{"name":"1 Department of Hematology and Cellular Therapy, National Reference Center for AL Amyloidosis and Other Monoclonal Immunoglobulin Deposit Diseases, University Hospital of Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Magy","sequence":"additional","affiliation":[{"name":"2 Department and Laboratory of Neurology, Reference Center for Neuromuscular Disorders (AOC), University Hospital of Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Arnulf","sequence":"additional","affiliation":[{"name":"3 Department of Hematology and Immunology, National Reference Center for AL Amyloidosis and Other Monoclonal Immunoglobulin Deposit Diseases, Saint-Louis hospital, APHP, Paris Cit\u00e9 University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bridoux","sequence":"additional","affiliation":[{"name":"4 Department of Nephrology, National Reference Center for AL Amyloidosis and Other Monoclonal Immunoglobulin Deposit Diseases, University Hospital Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murielle","family":"Roussel","sequence":"additional","affiliation":[{"name":"1 Department of Hematology and Cellular Therapy, National Reference Center for AL Amyloidosis and Other Monoclonal Immunoglobulin Deposit Diseases, University Hospital of Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"issue":"13","key":"2025120616334385200_hem2025000728C1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJMoa054494","article-title":"Prevalence of monoclonal gammopathy of undetermined significance","volume":"354","author":"Kyle","year":"2006","journal-title":"N Engl J Med"},{"issue":"8","key":"2025120616334385200_hem2025000728C2","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood-2006-03-001164","article-title":"Dangerous small B-cell clones","volume":"108","author":"Merlini","year":"2006","journal-title":"Blood"},{"issue":"14","key":"2025120616334385200_hem2025000728C3","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1182\/blood-2018-04-839480","article-title":"Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications","volume":"132","author":"Bridoux","year":"2018","journal-title":"Blood"},{"issue":"11","key":"2025120616334385200_hem2025000728C4","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.3324\/haematol.2019.239632","article-title":"Peripheral neuropathy and monoclonal gammopathy of undetermined significance: a population-based study including 15,351 cases and 58,619 matched controls","volume":"105","author":"R\u00f6gnvaldsson","year":"2020","journal-title":"Haematologica"},{"issue":"6","key":"2025120616334385200_hem2025000728C5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1600-0404.1992.tb06033.x","article-title":"Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies","volume":"85","author":"Nobile-Orazio","year":"2009","journal-title":"Acta Neurol Scand"},{"issue":"5","key":"2025120616334385200_hem2025000728C6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1212\/WNL.0000000000011324","article-title":"The wide spectrum of pathophysiologic mechanisms of paraproteinemic neuropathy","volume":"96","author":"Vallat","year":"2021","journal-title":"Neurology"},{"issue":"1","key":"2025120616334385200_hem2025000728C7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10654-015-0094-6","article-title":"The epidemiology and risk factors of chronic polyneuropathy","volume":"31","author":"Hanewinckel","year":"2016","journal-title":"Eur J Epidemiol"},{"issue":"3","key":"2025120616334385200_hem2025000728C8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1529-8027.2010.00278.x","article-title":"European Federation of Neurological Societies\/Peripheral Nerve Society Guideline* on management of paraproteinemic demyelinating neuropathies. 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