{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:44:37Z","timestamp":1789011877686,"version":"build-2803163510"},"reference-count":0,"publisher":"American Society of Hematology","issue":"9","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A novel leukemic cell line with an 8;21 chromosome translocation, designated as Kasumi-1, was established from the peripheral blood of a 7-year-old boy suffering from acute myeloid leukemia (AML). The Kasumi- 1 cells were positive for myeloperoxidase showing a morphology of myeloid maturation. The response in proliferation assay was observed in the culture with interleukin-3 (IL-3), IL-6, granulocyte colony- stimulating factor (G-CSF), and granulocytemacrophage CSF (GM-CSF), but not with IL-1 or IL-5. Neither granulocytic nor eosinophilic maturation was observed in the liquid culture by the addition of dimethyl sulfoxide, G-CSF, or IL-5, respectively. In contrast, induction of macrophagelike cells was seen by the addition of phorbol ester. This is the first report of a human AML cell line with t(8;21) that has characteristics of myeloid and macrophage lineages. The cell line could be a useful tool for elucidating the pathophysiology of AML with t(8;21).<\/jats:p>","DOI":"10.1182\/blood.v77.9.2031.2031","type":"journal-article","created":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T19:22:06Z","timestamp":1570994526000},"page":"2031-2036","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":230,"title":["Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation"],"prefix":"10.1182","volume":"77","author":[{"given":"H","family":"Asou","sequence":"first","affiliation":[{"name":"Department of Hematology, Hiroshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hiroshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hiroshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Otsuji","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hiroshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hiroshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hiroshima University, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/77\/9\/2031\/605414\/2031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/77\/9\/2031\/605414\/2031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T05:04:52Z","timestamp":1574226292000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/77\/9\/2031\/168500\/Establishment-of-a-human-acute-myeloid-leukemia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1991,5,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.v77.9.2031.2031","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,5,1]]}}}